Butanoic acid, 2-amino-4-(methyldithio)- | 65061-27-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Butanoic acid, 2-amino-4-(methyldithio)-
• 英文别名: 2-amino-4-(methyldisulfanyl)butanoic acid
• CAS: 65061-27-0
• 化学式: C₅H₁₁NO₂S₂
• 分子量: 181.28
• InChiKey: FBHYROPXAAGPRS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3
• 重原子数：
  10
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  114
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  Butanoic acid, 2-amino-4-(methyldithio)- 在 acylase from Aspergillus oryzae 、 水 作用下， 反应 6.0h， 生成 (S)-2-amino-4-(methyldisulfanyl)butanoic acid
  参考文献：
  名称：

  l-methionine related l-amino acids by acylase cleavage of their corresponding

  摘要：

  Acylase I from Aspergillus oryzae is an even more useful enzyme than suggested so far. Besides standard amino acids such as L-Met, L-VaI and L-Phe, a number of additional sulfur-and selenium-containing amino acids can be obtained at useful reaction rates and in very high enantiomeric purity by kinetic resolution of the respective N-acety-DL-amino acids. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0957-4166(97)00400-x
• 作为产物：
  描述：

  甲基硫代磺酸甲酯 、 DL-高半胱氨酸 生成 Butanoic acid, 2-amino-4-(methyldithio)-
  参考文献：
  名称：

  l-methionine related l-amino acids by acylase cleavage of their corresponding

  摘要：

  Acylase I from Aspergillus oryzae is an even more useful enzyme than suggested so far. Besides standard amino acids such as L-Met, L-VaI and L-Phe, a number of additional sulfur-and selenium-containing amino acids can be obtained at useful reaction rates and in very high enantiomeric purity by kinetic resolution of the respective N-acety-DL-amino acids. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0957-4166(97)00400-x

文献信息

• Method for the treatment of cancer by use of the copper complex of
  申请人：The United States of America as represented by the Department of Health

  公开号：US05385933A1

  公开（公告）日：1995-01-31

  A composition and a method for inhibiting cellular proliferation, such as the abnormal cellular proliferation characteristic of cancer cells. The method comprises the administration to a mammal, in particular a human, of an effective amount of S-(methylthio)-DL-homocysteine or S-(methylthio)-L-homocysteine, either simultaneously or sequentially, with an effective amount of a copper chelate such that an effective amount of an inhibitory complex forms in the mammal between the S-(methylthio)-homocysteine and the copper of the cooper chelate. The inhibitory complex is capable of inhibiting the proliferation of cells contacted by the inhibitory complex.

  一种抑制细胞增殖的组合物和方法，特别是抑制癌细胞的异常细胞增殖特征。该方法包括向哺乳动物，特别是人类，施加有效量的S-（甲硫基）-DL-同型半胱氨酸或S-（甲硫基）-L-同型半胱氨酸，同时或顺序施加有效量的铜螯合物，以便在哺乳动物中形成抑制性复合物的有效量，该复合物能够抑制受到抑制性复合物接触的细胞的增殖。
• YAMADA, TEHTSUO;TOGO, ITIDZI
  作者：YAMADA, TEHTSUO、TOGO, ITIDZI

  DOI：——

  日期：——
• l-methionine related l-amino acids by acylase cleavage of their corresponding
  作者：Andreas S. Bommarius、Karlheinz Drauz、Kurt Günther、Günter Knaup、Michael Schwarm

  DOI：10.1016/s0957-4166(97)00400-x

  日期：1997.10

  Acylase I from Aspergillus oryzae is an even more useful enzyme than suggested so far. Besides standard amino acids such as L-Met, L-VaI and L-Phe, a number of additional sulfur-and selenium-containing amino acids can be obtained at useful reaction rates and in very high enantiomeric purity by kinetic resolution of the respective N-acety-DL-amino acids. (C) 1997 Elsevier Science Ltd.