prop-2-enyl (4S,5R,6S)-6-[(1R)-1-[tert-butyl(dimethyl)silyl]oxyethyl]-3-formyl-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate | 220019-85-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酰胺类
• 英文名称: prop-2-enyl (4S,5R,6S)-6-[(1R)-1-[tert-butyl(dimethyl)silyl]oxyethyl]-3-formyl-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate
• CAS: 220019-85-2
• 化学式: C₂₀H₃₁NO₅Si
• 分子量: 393.555
• InChiKey: NZABXESMYOQHPG-SJXGUFTOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.06
• 重原子数：
  27
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  72.9
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  prop-2-enyl (4S,5R,6S)-6-[(1R)-1-[tert-butyl(dimethyl)silyl]oxyethyl]-3-formyl-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate 在 potassium fluoride 、 四(三苯基膦)钯 、 四丁基溴化铵 、 溶剂黄146 、 sodium 2-ethylhexanoic acid 作用下， 以 四氢呋喃 为溶剂， 反应 1.0h， 生成 (4S,5R,6S)-6-((R)-1-Hydroxy-ethyl)-3-((S)-1-hydroxy-propyl)-4-methyl-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid
  参考文献：
  名称：

  Synthesis and antibacterial activity of 2α-functionalized 1β-methylcarbapenems related to KR-21012

  摘要：

  The 2 alpha-functionalized 1 beta-merhylcarbapenems 3 were synthesized from the 2-formyl 1 beta-methylcarbapenem intermediate 5. The best compound in the series of 2 alpha-(hydroxy)alkylcarbapenems, KR-21012, displayed well balanced in vitro and in vivo activity as a parent compound of oral carbapenem. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(99)00692-7
• 作为产物：
  描述：

  (4S,5R,6S)-6-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-3-hydroxymethyl-4-methyl-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid allyl ester 在 manganese(IV) oxide 作用下， 以 二氯甲烷 为溶剂， 以70%的产率得到prop-2-enyl (4S,5R,6S)-6-[(1R)-1-[tert-butyl(dimethyl)silyl]oxyethyl]-3-formyl-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate
  参考文献：
  名称：

  Synthesis and antibacterial activity of 2α-functionalized 1β-methylcarbapenems related to KR-21012

  摘要：

  The 2 alpha-functionalized 1 beta-merhylcarbapenems 3 were synthesized from the 2-formyl 1 beta-methylcarbapenem intermediate 5. The best compound in the series of 2 alpha-(hydroxy)alkylcarbapenems, KR-21012, displayed well balanced in vitro and in vivo activity as a parent compound of oral carbapenem. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(99)00692-7

文献信息

• Synthesis and antibacterial activity of 2α-functionalized 1β-methylcarbapenems related to KR-21012
  作者：Hyun J. Kwak、Do K. Pyun、Jae H. Kim、Eun J. Kim、Hee J. Jeong、Bong J. Kim、Cheol H. Lee

  DOI：10.1016/s0960-894x(99)00692-7

  日期：2000.2

  The 2 alpha-functionalized 1 beta-merhylcarbapenems 3 were synthesized from the 2-formyl 1 beta-methylcarbapenem intermediate 5. The best compound in the series of 2 alpha-(hydroxy)alkylcarbapenems, KR-21012, displayed well balanced in vitro and in vivo activity as a parent compound of oral carbapenem. (C) 2000 Elsevier Science Ltd. All rights reserved.