perfluoroperhydroacenaphthene | 307-07-3

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 有机氟化物
• 英文名称: perfluoroperhydroacenaphthene
• 英文别名: eicosafluoro-dodecahydro-acenaphthylene；Eicosafluor-dodecahydro-acenaphthylen；Perfluor-decahydroacenaphthen；Acenaphthylene, eicosafluorododecahydro-；1,1,2,2,3,3,3a,4,4,5,5,5a,6,6,7,7,8,8,8a,8b-icosafluoroacenaphthylene
• CAS: 307-07-3
• 化学式: C₁₂F₂₀
• 分子量: 524.1
• InChiKey: VDXGSVGYMMTFHU-UHFFFAOYSA-N

物化性质

• 沸点：
  172 °C
• 密度：
  1.89±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  32
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  20

反应信息

• 作为反应物：
  描述：

  perfluoroperhydroacenaphthene 在 镍 作用下， 生成 全氟苊
  参考文献：
  名称：

  多环氟芳族化合物-III：八氟ac和十氟茚满，-ac，-蒽和-py

  摘要：

  通过用氟化钴对芳族烃进行氟化，已经制备了全氟过氢茚满，-芴，-,、-菲，-蒽和-ne。当在加热的金属丝网上在气相中脱氟时，得到全氟茚满，-ac烯，-ac烯，-蒽和-py。

  DOI：

  10.1016/0040-4020(63)85004-8
• 作为产物：
  描述：

  苊 在 cobalt (III) fluoride 作用下， 生成 perfluoroperhydroacenaphthene
  参考文献：
  名称：

  多环氟芳族化合物-III：八氟ac和十氟茚满，-ac，-蒽和-py

  摘要：

  通过用氟化钴对芳族烃进行氟化，已经制备了全氟过氢茚满，-芴，-,、-菲，-蒽和-ne。当在加热的金属丝网上在气相中脱氟时，得到全氟茚满，-ac烯，-ac烯，-蒽和-py。

  DOI：

  10.1016/0040-4020(63)85004-8

文献信息

• Perfluorocarbon liquids useful in eye treatment and diagnostic procedures
  申请人：CHILDREN'S HOSPITAL MEDICAL CENTER

  公开号：EP0089232A2

  公开（公告）日：1983-09-21

  Perfluorocarbon liquids are disclosed as being useful as substitutes for the vitreous or aqueous of the eye, and as transparentizing agents in the cornea or lens of the eye. Radiopaque liquid perfluorocarbons are useful as radiopaque agents in diagnostic procedures on the eye.

  已公开的全氟化碳液体可用作眼睛玻璃体或水液的替代物，也可用作眼睛角膜或晶状体的透明剂。 不透射线的液态全氟化碳可用作眼睛诊断程序中的不透射线剂。
• Artificial blood and other gas transport agents
  申请人：CHILDREN'S HOSPITAL MEDICAL CENTER

  公开号：EP0091820A1

  公开（公告）日：1983-10-19

  Gas transport agents containing a perfluorocyclocarbon and an amine oxide are disclosed. These compositions provide emulsions or solutions for use in oxygen transport, particularly in animals. They are therefore useful as artificial blood compositions. Large concentrations of perfluorocarbons may be employed even up to 50% or more by volume in preparing emulsions, microemulsions or solutions. The emulsions or solutions are stable under room temperature storage conditions

  本发明公开了含有全氟环碳化物和氧化胺的气体运输剂。这些组合物提供的乳液或溶液可用于氧气输送，特别是动物体内的氧气输送。因此，它们可用作人造血液组合物。在制备乳剂、微乳剂或溶液时，可以使用高浓度的全氟碳化合物，按体积计算甚至可高达 50%或以上。这些乳剂或溶液在室温储存条件下非常稳定
• Extraocular device for treating the eye
  申请人：CHILDREN'S HOSPITAL MEDICAL CENTER

  公开号：EP0112658A2

  公开（公告）日：1984-07-04

  Extraocular ophthalmic preparations or devices useful as therapeutic, diagnostic lubricating or protective agents are disclosed. Perfluorocarbon films or gels are employed extraocularly as contact lenses. Liquid perfluorocarbons and substituted derivatives are the active components of the ophthalmic preparations. The neat perfluorocarbon liquids are not aqueous, wherefore, isotonicity and pH need not be considered in their preparation. Liquid sterility may be maintained without the addition of preservatives. Cornea and conjunctiva surfaces are provided with greater amounts of oxygen when the perfluorcarbon liquids are employed as eye drops. Transparent contact lenses having oxygen permeable properties are provided by the extraocular perfluorocarbon films or discs. Emulsions of perfluorocarbons in water are also suitable for all of the above uses and as carriers for drugs, antibiotics, hormones and therapeutic agents.

  公开了可用作治疗、诊断润滑剂或保护剂的眼外眼科制剂或装置。全氟碳薄膜或凝胶可用作眼外隐形眼镜。液态全氟化碳和取代衍生物是眼科制剂的活性成分。纯净的全氟化碳液体不是水溶液，因此在制备过程中无需考虑等渗性和 pH 值。无需添加防腐剂即可保持液体无菌。当全氟碳化物液体用作滴眼液时，角膜和结膜表面可获得更多的氧气。眼外全氟碳化合物薄膜或圆片可提供具有透氧特性的透明隐形眼镜。全氟碳化合物在水中的乳化液也适用于上述所有用途，并可作为药物、抗生素、激素和治疗剂的载体。
• Delivery vehicles for bioactive agents and uses thereof
  申请人：Southern Research Institute

  公开号：US20020169138A1

  公开（公告）日：2002-11-14

  Compositions for transporting a bioactive agent across a biological membrane include the bioactive agent, an oil, an oil-immiscible compound and a noncationic surface active agent. The compositions may deliver the bioactive agent through a chemical microporulation mechanism, which allows transfer of the agent across both cellular, intracellular organelle, and nuclear membranes. Compositions for nucleic acid delivery include nucleic acid, oil, oil-immiscible compound, noncationic surface active agent and essentially no cationic lipid, or include nucleic acid, oil, oil-immiscible compound and two noncationic surface active agents. The nucleic acid may be hydrophobically-modified, and be in combination with an oil, an oil-immiscible compound and at least one surface active agent. The compositions may be used for gene delivery to a cell, as well as delivery of other therapeutic agents.

  用于跨生物膜传输生物活性剂的组合物包括生物活性剂、油、油不溶性化合物和非阳离子表面活性剂。这些组合物可通过化学微孔机制输送生物活性剂，从而实现生物活性剂在细胞膜、细胞内细胞器和核膜上的转移。用于递送核酸的组合物包括核酸、油、油不溶性化合物、非阳离子表面活性剂和基本不含阳离子的脂质，或包括核酸、油、油不溶性化合物和两种非阳离子表面活性剂。核酸可进行疏水改性，并与油、油不混溶化合物和至少一种表面活性剂结合使用。这些组合物可用于向细胞输送基因，也可用于输送其他治疗剂。
• Paramagnetic particles that provide improved relaxivity
  申请人：——

  公开号：US20030185760A1

  公开（公告）日：2003-10-02

  An improved contrast agent for magnetic resonance imaging comprises particles to each of which is coupled a multiplicity of chelating agents containing paramagnetic ions. In the improved agent, the position of the ion is offset from the surface of the particle so as to improve the relaxivity imparted by the contrast agent.

  一种用于磁共振成像的改进型造影剂由颗粒组成，每个颗粒上都耦合了多种含有顺磁离子的螯合剂。在改进型造影剂中，离子的位置偏离颗粒表面，以提高造影剂的弛豫性。