4-methyl-benzoic acid-(N-phenyl-hydrazide) | 29027-76-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-methyl-benzoic acid-(N-phenyl-hydrazide)
• 英文别名: 4-Methyl-benzoesaeure-(N-phenyl-hydrazid)；α-p-Toluyl-phenylhydrazin；toluylic acid phenyl hydrazide；p-toluic acid phenylhydrazide；p-Toluic acid, 1-phenylhydrazide；4-methyl-N-phenylbenzohydrazide
• CAS: 29027-76-7
• 化学式: C₁₄H₁₄N₂O
• 分子量: 226.278
• InChiKey: ZVMYZCNSIDMPFA-UHFFFAOYSA-N

物化性质

• 熔点：
  190-192 °C
• 沸点：
  385.4±35.0 °C(Predicted)
• 密度：
  1.189±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  46.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  戊二酸酐 、 4-methyl-benzoic acid-(N-phenyl-hydrazide) 以 溶剂黄146 为溶剂， 以38%的产率得到5-[2-(4-Methylbenzoyl)-2-phenylhydrazinyl]-5-oxopentanoic acid
  参考文献：
  名称：

  Shemchuk; Chernykh; Ivanova, Russian Journal of Organic Chemistry, 1997, vol. 33, # 4, p. 436 - 438

  摘要：

  DOI：
• 作为产物：
  描述：

  1-乙酰基-2-苯基肼 在 乙醚 、 硫酸 作用下， 生成 4-methyl-benzoic acid-(N-phenyl-hydrazide)
  参考文献：
  名称：

  v. Auwers; Mauss, Journal fur praktische Chemie (Leipzig 1954), 1927, vol. <2> 117, p. 331

  摘要：

  DOI：

文献信息

• Anthelmintic methods employing benzoyl chloride phenylhydrazones
  申请人：The Upjohn Company

  公开号：US03932661A1

  公开（公告）日：1976-01-13

  Certain benzoyl chloride phenylhydrazones have been found to be active against insects and mites, and they have also been found to be effective, broad-spectrum anthelmintics for suppressing parasitic worms in animals, particularly sheep. The benzoyl ring and the phenylhydrazone ring can be substituted with a halogen atom, a nitro group, or an alkyl group of from 1 to 6 carbon atoms, inclusive. A new class of pentahalobenzoyl chloride phenylhydrazones is described, particularly pentafluorobenzoyl chloride phenylhydrazones. The compounds are prepared by reacting a benzoic acid phenylhydrazide with phosphorus pentachloride to obtain a benzoyl chloride (dichlorophosphinyl)phenylhydrazone that is reacted with phenol to produce the desired benzoyl chloride phenylhydrazones. Certain of the compounds can be prepared by direct chlorination of a benzaldehyde phenylhydrazone. Methods of using the new compounds and new anthelmintic formulations are described. The new compound p-toluoyl chloride phenylhydrazone is effective against worms at rates at least as low as 100 mg./kg. of body weight in sheep.

  某些苯甲酰氯苯基肼已被发现对昆虫和螨具有活性，它们还被发现对动物，特别是羊体内的寄生虫蠕虫有抑制作用，是有效的广谱驱虫剂。苯甲酰环和苯基肼环可以被卤素原子、硝基团或含有1至6个碳原子的烷基取代。描述了一类新的五卤苯甲酰氯苯基肼，特别是五氟苯甲酰氯苯基肼。通过将苯甲酸苯基肼与五氯化磷反应以获得苯甲酰氯（二氯磷基）苯基肼，然后将其与酚反应以产生所需的苯甲酰氯苯基肼来制备这些化合物。其中的一些化合物可以通过对苯甲醛苯基肼进行直接氯化制备。描述了使用新化合物和新驱虫剂配方的方法。新化合物对羊体重至少为100毫克/千克的剂量具有对抗蠕虫的有效性。
• Method of use, composition, and compounds
  申请人：The Upjohn Company

  公开号：US04017540A1

  公开（公告）日：1977-04-12

  Certain benzoyl chloride phenylhydrazones have been found to be active against insects and mites. The benzoyl ring and the phenylhydrazone ring can be substituted with a halogen atom, a nitro group, or an alkyl group of from 1 to 6 carbon atoms, inclusive. A new class of pentahalobenzoyl chloride phenylhydrazones is described, particularly pentafluorobenzoyl chloride phenylhydrazones. A further new class of alkylbenzoyl chloride phenylhydrazones, particularly p-toluoyl chloride phenylhydrazones are also described. The compounds are prepared by reacting a benzoic acid phenylhydrazide with phosphorus pentachloride to obtain a benzoyl chloride (dichlorophosphinyl)phenylhydrazone that is reacted with phenol to produce the desired benzoyl chloride phenylhydrazones. Certain of the compounds can be prepared by direct chlorination of a benzaldehyde phenylhydrazone. Methods of use and compositions are described.

  某些苯甲酰氯苯肼已被发现对昆虫和螨类具有活性。苯甲酰环和苯肼酮环可被卤素原子、硝基团或含有1至6个碳原子的烷基取代。描述了一种新类五卤苯甲酰氯苯肼，特别是五氟苯甲酰氯苯肼。还描述了一种新类烷基苯甲酰氯苯肼，特别是对甲酰氯苯肼。这些化合物通过将苯甲酸苯肼与五氯化磷反应制备苯甲酰氯（二氯磷基）苯肼，然后与酚反应制备所需的苯甲酰氯苯肼。其中一些化合物可通过对苯甲醛苯肼直接进行氯化制备。描述了使用方法和组成物。
• 1,3,4-Oxadiazolon(2)-Verbindungen, Verfahren zu deren Herstellung und deren Verwendung als optische Aufheller
  申请人：HOECHST AKTIENGESELLSCHAFT

  公开号：EP0009095B1

  公开（公告）日：1982-01-13
• US3932661A
  申请人：——

  公开号：US3932661A

  公开（公告）日：1976-01-13
• US4017540A
  申请人：——

  公开号：US4017540A

  公开（公告）日：1977-04-12