tert-butyl (3R,4S)-3-{[[3-hydroxy-5-(3-methoxypropyl)benzyl](cyclopropyl)amino]carbonyl}-4-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}piperidine-1-carboxylate | 1026787-16-5

分子结构分类

有机化合物 - 有机杂环化合物 - 哌啶类

中文名称

——

中文别名

——

英文名称

tert-butyl (3R,4S)-3-{[[3-hydroxy-5-(3-methoxypropyl)benzyl](cyclopropyl)amino]carbonyl}-4-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}piperidine-1-carboxylate

英文别名

tert-butyl (3R,4S)-3-({cyclopropyl[3-hydroxy-5-(3-methoxypropyl)benzyl]amino}carbonyl)-4-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}piperidine-1-carboxylate；tert-Butyl (3R,4S)-3-({cyclopropyl[3-hydroxy-5-(3-methoxypropyl)benzyl]-amino}carbonyl)-4-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}piperidine-1-carboxylate；tert-butyl (3R,4S)-3-[cyclopropyl-[[3-hydroxy-5-(3-methoxypropyl)phenyl]methyl]carbamoyl]-4-[4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl]piperidine-1-carboxylate

tert-butyl (3R,4S)-3-{[[3-hydroxy-5-(3-methoxypropyl)benzyl](cyclopropyl)amino]carbonyl}-4-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}piperidine-1-carboxylate化学式

CAS

1026787-16-5

化学式

C₄₀H₅₀Cl₂N₂O₇

mdl

——

分子量

741.752

InChiKey

YKMMTGRBWWISEG-NOCHOARKSA-N

BEILSTEIN

——

EINECS

——

计算性质

辛醇/水分配系数(LogP)：

7.9
重原子数：

51
可旋转键数：

16
环数：

5.0
sp3杂化的碳原子比例：

0.5
拓扑面积：

97.8
氢给体数：

1
氢受体数：

7

上下游信息

上游原料

中文名称	英文名称	CAS号	化学式	分子量
——	tert-butyl (3R,4S)-3-({[3-{[(tert-butyl)(dimethyl)silyl]oxy}-5-(3-methoxypropyl)benzyl](cyclopropyl)amino}carbonyl)-4-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}piperidine-1-carboxylate	1026787-15-4	C₄₆H₆₄Cl₂N₂O₇Si	856.015
——	(3R,4S)-4-(4-(2-(2,6-dichloro-4-methylphenoxy)ethoxy)phenyl)piperidine-1,3-dicarboxylic acid 1-tert-butyl ester	946003-24-3	C₂₆H₃₁Cl₂NO₆	524.441
——	1-(tert-butyl) 3-ethyl (3R,4S)-4-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}piperidine-1,3-dicarboxylate	1026786-65-1	C₂₈H₃₅Cl₂NO₆	552.495
——	1-(tert-butyl) 3-ethyl 4-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}piperidine-1,3-dicarboxylate	1026786-63-9	C₂₈H₃₅Cl₂NO₆	552.495
——	1-tert-butyl 3-ethyl-4-{4-(2-(2,6-dichloro-4-methyl-phenoxy)ethoxy)phenyl}-5,6-dihydro-pyridine-1,3(2H)-dicarboxylate	1026786-61-7	C₂₈H₃₃Cl₂NO₆	550.479

下游产品

中文名称	英文名称	CAS号	化学式	分子量
——	tert-butyl (3R,4S)-3-{[[3-(2-metoxy-ethoxy)-5-(3-methoxypropyl)benzyl](cyclopropyl)amino]carbonyl}-4-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}piperidine-1-carboxylate	1026787-17-6	C₄₃H₅₆Cl₂N₂O₈	799.832
——	tert-butyl (3R,4S)-3-((cyclopropyl(3-(2-cyclopropoxy-ethoxy)-5-(3-methoxypropyl)benzyl)amino)carbonyl)-4-(4-(2-(2,6-dichloro-4-methyl-phenoxy)-ethoxy)phenyl)-piperidine-1-carboxylate	1026787-22-3	C₄₅H₅₈Cl₂N₂O₈	825.87
——	tert-butyl (3R,4S)-3-((cyclopropyl(3-(2-(dimethylamino)ethoxy)-5-(3-methoxypropyl)benzyl)amino)carbonyl)-4-(4-(2-(2,6-dichloro-4-methyl-phenoxy)-ethoxy)phenyl)-piperidine-1-carboxylate	1026787-20-1	C₄₄H₅₉Cl₂N₃O₇	812.874
——	tert-butyl (3R,4S)-3-{[[3-(3-cyanopropoxy)-5-(3-methoxypropyl)benzyl](cyclopropyl)amino]carbonyl}-4-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}piperidine-1-carboxylate	1087347-39-4	C₄₄H₅₅Cl₂N₃O₇	808.843
——	tert-butyl (3R,4S)-3-((cyclopropyl(3-(2-hydroxy-2-methylpropoxy)-5-(3-methoxypropyl)benzyl)amino)carbonyl)-4-(4-(2-(2,6-dichloro-4-methyl-phenoxy)-ethoxy)phenyl)-piperidine-1-carboxylate	1026787-26-7	C₄₄H₅₈Cl₂N₂O₈	813.859
——	tert-butyl (3R,4S)-3-((cyclopropyl(3-(2-(2,2,2-trifluoroethoxy)-ethoxy)-5-(3-methoxypropyl)benzyl)amino)carbonyl)-4-(4-(2-(2,6-dichloro-4-methyl-phenoxy)-ethoxy)phenyl)-piperidine-1-carboxylate	1026787-24-5	C₄₄H₅₅Cl₂F₃N₂O₈	867.831
——	tert-butyl (3R,4S)-3-({(cyclopropyl)[3-(4-ethoxy-4-oxobutoxy)-5-(3-methoxypropyl)benzyl]amino}carbonyl)-4-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}piperidine-1-carboxylate	1087347-38-3	C₄₆H₆₀Cl₂N₂O₉	855.896
——	tert-butyl (3R,4S)-3-{[[3-[(4-cyanobenzyl)oxy]-5-(3-methoxypropyl)benzyl](cyclopropyl)amino]carbonyl}-4-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}piperidine-1-carboxylate	1087347-42-9	C₄₈H₅₅Cl₂N₃O₇	856.887
——	tert-butyl (3R,4S)-3-[((cyclopropyl){3-(3-methoxypropyl)-5-[3-(2H-tetrazol-5-yl)propoxy]benzyl}amino)carbonyl]-4-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}piperidine-1-carboxylate	1087347-40-7	C₄₄H₅₆Cl₂N₆O₇	851.871
——	tert-butyl (3R,4S)-3-({(cyclopropyl)[3-(4-methoxy-3,3-dimethyl-4-oxobutoxy)-5-(3-methoxypropyl)benzyl]amino}carbonyl)-4-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}piperidine-1-carboxylate	1087347-44-1	C₄₇H₆₂Cl₂N₂O₉	869.923
——	tert-butyl (3R,4S)-3-(((3-((1-(cyanomethyl)cyclopropyl)methoxy)-5-(3-methoxypropyl)-benzyl)(cyclopropyl)amino)carbonyl)-4-(4-(2-(2,6-dichloro-4-methylphenoxy)ethoxy)phenyl)-piperidine-1-carboxylate	1026787-28-9	C₄₆H₅₇Cl₂N₃O₇	834.88
——	(1S,2S)-2-((3-(((3R,4S)-1-(tert-butoxycarbonyl)-N-cyclopropyl-4-(4-(2-(2,6-dichloro-4-methylphenoxy)ethoxy)phenyl)piperidine-3-carboxamido)methyl)-5-(3-methoxypropyl)phenoxy)methyl)cyclopropane-1-carboxylic acid	1303607-09-1	C₄₅H₅₆Cl₂N₂O₉	839.854
——	(1R,2R)-2-{[3-{[[((3R,4S)-1-(tert-butoxycarbonyl)-4-{4-[2-(2.6-dichloro-4-methylphenoxy)ethoxy]phenyl}piperidin-3-yl)carbonyl](cyclopropyl)amino]methyl}-5-(3-methoxypropyl)phenoxy]methyl}cyclopropane-1-carboxylic acid	1087347-30-5	C₄₅H₅₆Cl₂N₂O₉	839.854
——	tert-butyl (3R,4S)-3-({(cyclopropyl)[3-{[4-(methoxycarbonyl)benzyl]oxy}-5-(3-methoxypropyl)benzyl]amino}carbonyl)-4-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}piperidine-1-carboxylate	1087347-41-8	C₄₉H₅₈Cl₂N₂O₉	889.914
——	(1-{[3-{[[((3R,4S)-1-(tert-butoxycarbonyl)-4-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}piperidin-3-yl)carbonyl](cyclopropyl)amino]methyl}-5-(3-methoxypropyl)phenoxy]methyl}cyclopropyl)acetic acid	1087347-35-0	C₄₆H₅₈Cl₂N₂O₉	853.881
——	tert-butyl (3R,4S)-3-((cyclopropyl-(3-(3-methoxy-propyl)-5-trifluoromethylsulfonyloxy-benzyl)amino)carbonyl)-4-(4-(2-(2,6-dichloro-4-methylphenoxy)ethoxy)phenyl)piperidine-1-carboxylate	1026787-34-7	C₄₁H₄₉Cl₂F₃N₂O₉S	873.815
——	tert-butyl (3R,4S)-3-({(cyclopropyl)[3-{[1-(2-methoxy-2-oxoethyl)cyclopropyl]methoxy}-5-(3-methoxypropyl)benzyl]amino}carbonyl)-4-{4-[2-(2.,6-dichloro-4-methylphenoxy)ethoxy]phenyl}piperidine-1-carboxylate	1087347-34-9	C₄₇H₆₀Cl₂N₂O₉	867.907
——	tert-butyl (3R,4S)-3-({cyclopropyl[3-{[(1R,2R)-2-ethoxycarbonyl-cyclopropyl]methoxy}-5-(3-methoxypropyl)benzyl]amino}-carbonyl)-4-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}piperidine-1-carboxylate	1026787-31-4	C₄₇H₆₀Cl₂N₂O₉	867.907
——	tert-butyl (3R,4S)-3-(cyclopropyl(3-(((1S,2S)-2-(ethoxycarbonyl)cyclopropyl)methoxy)-5-(3-methoxypropyl)benzyl)carbamoyl)-4-(4-(2-(2,6-dichloro-4-methylphenoxy)ethoxy)phenyl)piperidine-1-carboxylate	1303607-08-0	C₄₇H₆₀Cl₂N₂O₉	867.907
——	tert-butyl (3R,4S)-3-{[(cyclopropyl)(3-(3-methoxypropyl)-5-{[1-(2H-tetrazol-5-ylmethyl)cyclopropyl]methoxy}benzyl)amino]carbonyl}-4-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}piperidine-1-carboxylate	1087347-37-2	C₄₆H₅₈Cl₂N₆O₇	877.909
——	tert-butyl (3R,4S)-3-{[(cyclopropyl)(3-(3-methoxypropyl)-5-{[4-(1H-tetrazol-5-yl)benzyl]oxy}benzyl)amino]carbonyl}-4-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}piperidine-1-carboxylate	1087347-43-0	C₄₈H₅₆Cl₂N₆O₇	899.915
——	tert-butyl (3R,4S)-3-({cyclopropyl-[3-[((1R,2R)-2-{[2-(dimethylamino)-2-oxo-ethoxy]carbonyl}cyclopropyl)methoxy]-5-(3-methoxypropyl)benzyl]amino}carbonyl)-4-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}piperidine-1-carboxylate	1087347-31-6	C₄₉H₆₃Cl₂N₃O₁₀	924.959
——	tert-butyl (3R,4S)-3-{[[3-({1-[2-(benzyloxy)-2-oxoethyl]cyclopropyl}methoxy)-5-(3-methoxypropyl)benzyl](cyclopropyl)amino]carbonyl}-4-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}piperidine-1-carboxylate	1087347-36-1	C₅₃H₆₄Cl₂N₂O₉	944.005
——	tert-butyl (3R,4S)-3-({(cyclopropyl)[3-({(1R,2R)-2-[(2,3-dihydro-1H-indol-5-yloxy)carbonyl]cyclopropyl}methoxy)-5-(3-methoxypropyl)benzyl]amino}carbonyl)-4-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}piperidine-1-carboxylate	1087347-32-7	C₅₄H₆₄Cl₂N₂O₉	956.016
——	(3R,4S)-N-cyclopropyl-4-(4-(2-(2,6-dichloro-4-methylphenoxy)ethoxy)-phenyl)-N-[3-(2-hydroxy-2-methyl-propoxy)-5-(3-methoxypropyl)benzyl]piperidine-3-carboxamide	1026787-25-6	C₃₉H₅₀Cl₂N₂O₆	713.742
——	(3R,4S)-N-cyclopropyl-4-(4-(2-(2,6-dichloro-4-methylphenoxy)ethoxy)phenyl)-N-(3-(3-(3-ethylureido)propoxy)-5-(3-methoxypropyl)benzyl)piperidine-3-carboxamide	1303607-36-4	C₄₁H₅₄Cl₂N₄O₆	769.809
——	(3R,4S)-N-cyclopropyl-4-(4-(2-(2,6-dichloro-4-methylphenoxy)ethoxy)-phenyl)-N-(3-(3-methoxy-propyl)-5-[2-(2,2,2-trifluoro-ethoxy)ethoxy]benzyl)-piperidine-3-carboxamide	1026787-23-4	C₃₉H₄₇Cl₂F₃N₂O₆	767.713
——	tert-butyl (3R,4S)-3-{[[3-{[(1R,2R)-2-({[(5R)-5,6-bis(nitrooxy)hexyl]oxy}carbonyl)cyclopropyl]methoxy}-5-(3-methoxypropyl)benzyl](cyclopropyl)amino]carbonyl}-4-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}piperidine-1-carboxylate	1087347-33-8	C₅₁H₆₆Cl₂N₄O₁₅	1046.01
——	(3R,4S)-N-cyclopropyl-4-[4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl]-N-[[3-[3-(methanesulfonamido)propoxy]-5-(3-methoxypropyl)phenyl]methyl]piperidine-3-carboxamide	1303607-34-2	C₃₉H₅₁Cl₂N₃O₇S	776.822
——	(1S,2S)-2-{[3-({cyclopropyl[((3R,4S)-4-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}piperidin-3-yl)carbonyl]amino}methyl)-5-(3-methoxypropyl)phenoxy]methyl}cyclopropane-1-carboxylic acid	1087347-12-3	C₄₀H₄₈Cl₂N₂O₇	739.736