5-nitro-2-(octyloxy)benzohydrazide | 1186586-61-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-nitro-2-(octyloxy)benzohydrazide
• CAS: 1186586-61-7
• 化学式: C₁₅H₂₃N₃O₄
• 分子量: 309.365
• InChiKey: GNLCKRIUHUPOKM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.94
• 重原子数：
  22.0
• 可旋转键数：
  10.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  107.49
• 氢给体数：
  2.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  BOC-L-脯氨酸 、 5-nitro-2-(octyloxy)benzohydrazide 在 1,2-二氯乙烷 作用下， 以 二氯甲烷 为溶剂， 反应 5.0h， 以87%的产率得到
  参考文献：
  名称：

  Noncovalent Synthesis of Shape-Persistent Cyclic Hexamers from Ditopic Hydrazide-Based Supramolecular Synthons and Asymmetric Induction of Supramolecular Chirality

  摘要：

  With properly encoded recognition sites and a well-defined algorithm for intermolecular and intramolecular interactions, the 120 degrees spacer linked ditopic hydrazide-based supramolecular synthons were found to self-assemble into shape-persistent cyclic hexamers in apolar solvents. The two hydrazide motifs displayed separate sets of signals in the NMR spectra because of the interlocked conformation. While in hydrogen bonding competitive solvent such as DMSO-d(6) the spectra were in agreement with the structures with C-2 axes Moreover, the terminative groups were found to affect the stability of the assemblies substantially. Consequently, the monomer with ureido-hydrazide terminative groups could form the most stable cyclic hexamer in solution for the attractive spectator secondary electrostatic interactions. Owing to the dynamically and kinetically stable nature of these kinds of assemblies, the assembly from the monomer with chiral auxiliary terminative groups also displayed supramolecular chirality in solution, which was confirmed by concentration-dependent CD spectra.

  DOI：

  10.1021/ja9029335
• 作为产物：
  描述：

  5-nitro-2-octyloxybenzoic acid methyl ester 在 肼 作用下， 以 甲醇 为溶剂， 反应 24.0h， 以95%的产率得到5-nitro-2-(octyloxy)benzohydrazide
  参考文献：
  名称：

  Noncovalent Synthesis of Shape-Persistent Cyclic Hexamers from Ditopic Hydrazide-Based Supramolecular Synthons and Asymmetric Induction of Supramolecular Chirality

  摘要：

  With properly encoded recognition sites and a well-defined algorithm for intermolecular and intramolecular interactions, the 120 degrees spacer linked ditopic hydrazide-based supramolecular synthons were found to self-assemble into shape-persistent cyclic hexamers in apolar solvents. The two hydrazide motifs displayed separate sets of signals in the NMR spectra because of the interlocked conformation. While in hydrogen bonding competitive solvent such as DMSO-d(6) the spectra were in agreement with the structures with C-2 axes Moreover, the terminative groups were found to affect the stability of the assemblies substantially. Consequently, the monomer with ureido-hydrazide terminative groups could form the most stable cyclic hexamer in solution for the attractive spectator secondary electrostatic interactions. Owing to the dynamically and kinetically stable nature of these kinds of assemblies, the assembly from the monomer with chiral auxiliary terminative groups also displayed supramolecular chirality in solution, which was confirmed by concentration-dependent CD spectra.

  DOI：

  10.1021/ja9029335

文献信息

• Multiple Hydrogen-Bond-Mediated Molecular Duplexes Based on the Self-Complementary Amidourea Motif
  作者：Wei-Jun Chu、Yong Yang、Chuan-Feng Chen

  DOI：10.1021/ol101068n

  日期：2010.7.16

  The self-complementary amidourea motif, which was stabilized by four intermolecular tricenter hydrogen bonds, was investigated in solution and in the solid state. Extensive studies on oligomer 2 indicated that the hydrogen-bonding mode could persist in longer molecular duplexes based on the amidourea motif. The dimerization constants of 2b·2b in various DMSO-d6/CDCl3 mixtures were determined quantitatively

  在溶液和固态下，研究了通过四个分子间三中心氢键稳定的自互补阿米杜里亚基序。对低聚物2的广泛研究表明，基于amidourea基序，氢键合模式可以在更长的分子双链体中持续存在。通过1 H NMR稀释研究定量确定了各种DMSO- d 6 / CDCl 3混合物中2b·2b的二聚常数，这表明同双链体在低极性溶剂中高度稳定。