(R)-N-tert-butyl-2-hydroxy-2-phenylacatamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (R)-N-tert-butyl-2-hydroxy-2-phenylacatamide
• 英文别名: (R)-N-tert-butyl-2-hydroxy-2-phenylacetamide；(R)-N-t-butylmandelamide；(2R)-N-tert-butyl-2-hydroxy-2-phenylacetamide
• 化学式: C₁₂H₁₇NO₂
• 分子量: 207.272
• InChiKey: TYILRWKOBWOVII-SNVBAGLBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  异氰酸叔丁酯 在 (S)-tert-leucinol 3,5-di-t-Bu-salicylidene derivative 、 氧气 、 三异丙氧基氧化钒 、 苯甲酸 作用下， 以 四氢呋喃 、 丙酮 为溶剂， 40.0~50.0 ℃ 、101.33 kPa 条件下， 反应 34.0h， 生成 (R)-N-tert-butyl-2-hydroxy-2-phenylacatamide
  参考文献：
  名称：

  使用分子氧作为化学计量氧化剂的钒催化α-羟基酯的不对称氧化

  摘要：

  描述了使用氧作为末端氧化剂的 α-羟基酯的氧化动力学拆分的钒催化方法。该催化剂由三异丙氧基氧化钒 (V) 与衍生自 3,5-二-叔丁基水杨醛和 (S)-叔亮氨醇的三齿配位体结合而原位生成。该反应允许对映选择性合成芳香族和脂肪族仲醇，包括含有烯烃和炔烃的仲醇。

  DOI：

  10.1021/ja0433424

文献信息

• BICHEPRu complexes, highly efficient catalysts for asymmetric hydrogenation of carbonyl compounds
  作者：Takeshi Chiba、Akira Miyashita、Hiroyuki Nohira、Hidemasa Takaya

  DOI：10.1016/s0040-4039(00)77611-8

  日期：1993.4

  [RuX(p-cymene)(bichep)]X, (X = I, Cl) and Ru(OAc)2(bichep) (bichep = 2,2′-bis(dicyclohexylphosphino)-6,6′-dimethyl-1,1′-biphenyl) proved to be highly efficient catalysts for asymmetric hydrogenation of carbonyl compounds bearing phenylglyoxyloyl group under mild conditions.

  新制备的[RuX（p-cymene）（bichep）] X，（X = I，Cl）和Ru（OAc）2（bichep）（bichep = 2,2'-双（二环己基膦基）-6,6'-二甲基-1,1'-联苯）被证明是在温和条件下对带有苯基乙二酰氯的羰基化合物进行不对称加氢的高效催化剂。
• The First Catalytic, Asymmetric α-Additions of Isocyanides. Lewis-Base-Catalyzed, Enantioselective Passerini-Type Reactions
  作者：Scott E. Denmark、Yu Fan

  DOI：10.1021/ja035410c

  日期：2003.7.1

  The first, catalytic, enantioselective alpha-additions of isocyanides to aldehydes have been demonstrated (Passerini-type reactions). The catalytic system of silicon tetrachloride and a chiral bisphosphoramide 5a provided high yields and good to excellent enantioselectivities for the addition of tert-butyl isocyanide to a wide range of aldehydes (aromatic, olefinic, acetylenic, aliphatic). Aqueous

  第一个，异氰化物与醛的催化、对映选择性 α 加成反应已经被证明（Passerini 型反应）。四氯化硅和手性双磷酰胺 5a 的催化体系提供了高产率和良好的对映选择性，用于将叔丁基异氰化物加成到多种醛（芳香族、烯烃、炔属、脂肪族）。水性后处理提供α-羟基叔丁基酰胺，而甲醇淬灭随后进行碱性后处理提供α-羟基甲基酯。
• Quinoxalinyl macrocyclic hepatitis C serine protease inhibitors
  申请人：Nakajima Suanne

  公开号：US20070060510A1

  公开（公告）日：2007-03-15

  The present invention relates to compounds of Formula I or II, or a pharmaceutically acceptable salt, ester, or prodrug, thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

  本发明涉及公式I或II的化合物，或其药学上可接受的盐、酯或前药，其抑制丝氨酸蛋白酶活性，特别是丝氨酸蛋白酶NS3-NS4A的活性。因此，本发明的化合物干扰丙型肝炎病毒的生命周期，也可用作抗病毒剂。本发明还涉及包含上述化合物的制药组合物，用于治疗丙型肝炎病毒感染的患者。本发明还涉及通过给予本发明化合物的制药组合物来治疗患有丙型肝炎病毒感染的患者的方法。
• Straightforward Enzymatic Process Based on HNL CLEA-Catalysis towards Cyanohydrin Derivatives
  作者：Fabien L. Cabirol、Angela E. C. Lim、Ulf Hanefeld、Roger A. Sheldon

  DOI：10.1021/op900207n

  日期：2010.1.15

  An efficient enzymatic process based on HNL-CLEA catalysis in buffer-saturated organic media was developed to limit the amount of overall waste generated and the number of safety issues incurred by handling HCN-containing waste. Starting front benzaldehyde as a model substrate, (R)- and (S)-mandelonitrile can be obtained under these reaction conditions without in extraction step being required. The crude cyanohydrin intermediate was sufficiently pure to be used as starting material in a second step towards a range of derivatives.
• US7176208B2
  申请人：——

  公开号：US7176208B2

  公开（公告）日：2007-02-13