1-phenyl-1,1,2-trimethoxyethane | 143191-51-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-phenyl-1,1,2-trimethoxyethane
• 英文别名: (1,1,2-trimethoxyethyl)benzene；1,1,2-trimethoxyethylbenzene
• CAS: 143191-51-9
• 化学式: C₁₁H₁₆O₃
• 分子量: 196.246
• InChiKey: FGCQQWNFAQGUDO-UHFFFAOYSA-N

物化性质

• 沸点：
  237.5±35.0 °C(Predicted)
• 密度：
  1.023±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  27.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-phenyl-1,1,2-trimethoxyethane 在 盐酸 作用下， 以100%的产率得到2-甲氧基苯乙酮
  参考文献：
  名称：

  Rozen, Shlomo; Mishani, Eyal; Kol, Moshe, Journal of the American Chemical Society, 1992, vol. 114, # 20, p. 7643 - 7645

  摘要：

  DOI：
• 作为产物：
  描述：

  α-methoxystyrene 、 methyl hypofluorite 以 氯仿 、 乙腈 为溶剂， 以87%的产率得到1-phenyl-1,1,2-trimethoxyethane
  参考文献：
  名称：

  Rozen, Shlomo; Mishani, Eyal; Kol, Moshe, Journal of the American Chemical Society, 1992, vol. 114, # 20, p. 7643 - 7645

  摘要：

  DOI：

文献信息

• The effect of electrolysis conditions on the oxidation of styrene in methanol
  作者：Yu. N. Ogibin、A. I. Ilovaiskii、G. I. Nikishin

  DOI：10.1007/bf00697143

  日期：1994.9

  effect of the anion of the supporting electrolyte and of the anode material on this process have been studied. The most efficient conversion of1 into (1,2-dimethoxyethyl)benzene (2) occurs when the electrolysis is carried out with a platinum anode and with potassium fluoride or tetrabutylammonium tetrafluoroborate as the supporting electrolyte. Cleavage of the C-C σ bond in2 to give benzaldehyde dimethylacetal

  已经研究了苯乙烯 (1) 在甲醇中的阳极氧化以及支持电解质和阳极材料的阴离子对该过程的影响。当使用铂阳极和氟化钾或四氟硼酸四丁基铵作为支持电解质进行电解时，1 向 (1,2-二甲氧基乙基) 苯 (2) 的最有效转化发生。在甲苯磺酸钠存在下，在石墨阳极上，CC σ 键在 2 中的裂解得到苯甲醛二甲基乙缩醛 (3) 是最有效的。
• Phenylsulphonylipiperazinyl derivatives as 5-ht receptor ligands
  申请人：——

  公开号：US20030181464A1

  公开（公告）日：2003-09-25

  A class of phenylsulphonyl derivatives of the following formula (I) wherein Z represents halogen, cyano, nitro, trifluoromethyl, trifluoromethoxy, —R a , —OR a , —SR a , —SOR a , —SO 2 R a , —SO 2 NR a R b , —NR a R b , —NR a COR b , —NR a CO 2 R b ; —COR a ; —CO 2 R a or —CONR a R b ; or Z represents an optionally substituted five-membered heteroaromatic ring selected from furan, thiophene, pyrrole, oxazole, thiazole, isoxazole, isothiazole, imidazole, pyrazole, oxadiazole, thiadiazole, triazole and tetrazole; or Z represents an optionally substituted six-membered heteroaromatic ring selected from pyridine, pyrazine, pyrimidine and pyridazine; R a and R b independently represent hydrogen of C 1-6 alkyl, or R a and R b , when linked through a nitrogen atom, together represent the residue of an azetidine, pyrrolidine, piperidine or morpholine ring; E represents a chemical bond or a straight or branched alkylene chain containing from 1 to 4 carbon atoms, optionally incorporating an oxygen atom to form an ether linkage; R 1 represents an optionally substituted aryl(C 2-4 )alkyl group; and R 2 represents hydrogen or halogen, which are selective antagonists of the human 5-HT 2A receptor an are therefore useful as pharmaceutical agents, especially in the treatment and/or prevention of adverse conditions of the central nervous system, including schizophrenia and depression.

  以下式子(I)的苯基磺酰衍生物类，其中Z代表卤素、氰基、硝基、三氟甲基、三氟甲氧基、—Ra、—ORa、—SRa、—SORa、—SO2Ra、—SO2NRaRb、—NRaRb、—NRaCORb、—NRaCO2Rb、—CORa、—CO2Ra或—CONRaRb；或Z代表可选取自呋喃、噻吩、吡咯、噁唑、噻唑、异噁唑、异硫咪唑、咪唑、吡唑、噻二唑、氧嘧啶、硫嘧啶、三唑和四唑的取代五元杂环芳基环；或Z代表可选取自吡啶、吡嗪、嘧啶和吡嗪嗪的取代六元杂环芳基环；Ra和Rb独立地代表氢、C1-6烷基或当通过氮原子连接时，Ra和Rb共同代表氮杂环丙氮、吡咯烷、哌啶或吗啉环的残基；E代表化学键或含有1-4个碳原子的直链或支链烷基链，可选地包含氧原子形成醚键；R1代表可选取代的芳基(C2-4)烷基基团；R2代表氢或卤素，它们是人类5-HT2A受体的选择性拮抗剂，因此在治疗和/或预防中枢神经系统的不良状况，包括精神分裂症和抑郁症方面，是有用的药物。
• [EN] PHENYLSULPHONYL DERIVATIVES AS 5-HT RECEPTOR LIGANDS<br/>[FR] DERIVES DE PHENYLSULPHONYLE EN TANT QUE LIGANDS DU RECEPTEUR 5-HT
  申请人：MERCK SHARP & DOHME

  公开号：WO2000043362A1

  公开（公告）日：2000-07-27

  A class of phenylsulphonyl derivatives wherein the sulphonyl moiety is also attached to an N-arylalkyl-substituted azetidine, pyrrolidine or piperidine ring are selective antagonists of the human 5-HT2A receptor and are therefore useful as pharmaceutical agents, especially in the treatment and/or prevention of adverse conditions of the central nervous system, including schizophrenia and depression.

  一类苯磺酰基衍生物，其中磺酰基部分也附着在N-芳基烷基取代的氮杂环丙烷，吡咯烷或哌啶环上，是人类5-HT2A受体的选择性拮抗剂，因此可用作药物，特别是用于治疗和/或预防中枢神经系统的不良病症，包括精神分裂症和抑郁症。
• Phenylsulphonyl derivatives as 5-HT receptor ligands
  申请人：Merck & Co., Inc.

  公开号：US20030203889A1

  公开（公告）日：2003-10-30

  A class of phenylsulphonyl derivatives wherein the sulphonyl moiety is also attached to an N-arylalkyl-substituted azetidine, pyrrolidine or piperidine ring are selective antagonists of the human 5-HT 2A receptor and are therefore useful as pharmaceutical agents, especially in the treatment and/or prevention of adverse conditions of the central nervous system, including schizophrenia and depression.

  一类苯磺酰衍生物，其中磺酰基还与N-芳基烷基取代的氮杂环（如氮杂环戊烷、吡咯烷或哌啶）环结合，是人类5-HT2A受体的选择性拮抗剂，因此在药物制剂中具有广泛的应用，尤其是在治疗和/或预防中枢神经系统的不良症状，包括精神分裂症和抑郁症方面。
• Use of imidazole derivative for antihypertensive agent
  申请人：NIPPON CHEMIPHAR CO., LTD.

  公开号：EP0633026A1

  公开（公告）日：1995-01-11

  The disclosed antihypertensive agent comprises an imidazole derivative of the formula: wherein each of R¹ and R² is hydrogen, substituted or unsubstituted alkyl, alkoxyalkyl, cycloalkyl, aryl, aralkyl, or R¹ and R² are combined to form hetero ring; each of R3, R4, R⁵ and R⁶ is hydrogen, halogen, substituted or unsubstituted alkoxy, substituted or unsubstituted alkyl, aryl, aryloxy, alkoxycarbonyl, nitro, amino, acyl, or R³ is combined with R² to form heteroring; R⁷ is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, substituted or unsubstituted arylcarbonyl, or S-containing heteroring; each of R⁸and R⁹ is hydrogen, halogen, substituted or unsubstituted alkoxy, unsubstituted or substituted alkyl, alkoxycarbonyl, aralkyl, nitro, amino, acyl, substituted or unsubstituted aryl, or R⁸ and R⁹ are combined to from alkylene; and n is 0 or 1.

  所公开的降压制剂包括式中的咪唑衍生物： 其中R¹和R²各自为氢、取代或未取代的烷基、烷氧基烷基、环烷基、芳基、芳烷基，或R¹和R²结合形成杂环；R3、R4、R⁵和R⁶各自为氢、卤素、取代或未取代的烷氧基、取代或未取代的烷基、芳基、芳氧基、烷氧基羰基、硝基、氨基、酰基，或R³与R²结合形成杂环；R⁷ 是氢、取代或未取代的烷基、取代或未取代的芳基、取代或未取代的芳羰基或含 S 的杂环；R⁸ 和 R⁹ 中的每一个是氢、卤素、取代或未取代的烷氧基、未取代或取代的 烷基、烷氧羰基、芳基、硝基、氨基、酰基、取代或未取代的芳基，或者 R⁸ 和 R⁹ 组合为亚烷基；以及 n 是 0 或 1。