6-(3'-amino phenyl)-2,3,4,5-tetrahydro pyridazin-3-one | 21282-91-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 6-(3'-amino phenyl)-2,3,4,5-tetrahydro pyridazin-3-one
• 英文别名: 6-(3-amino-phenyl)-4,5-dihydro-2H-pyridazin-3-one；3-(3-aminophenyl)-4,5-dihydro-1H-pyridazin-6-one
• CAS: 21282-91-7
• 化学式: C₁₀H₁₁N₃O
• 分子量: 189.217
• InChiKey: CNUKBTKCZHRKRG-UHFFFAOYSA-N

物化性质

• 熔点：
  90 °C(Solv: ethanol (64-17-5))
• 密度：
  1.35±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  67.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  6-(3'-amino phenyl)-2,3,4,5-tetrahydro pyridazin-3-one 以 二苯醚 为溶剂， 生成 4-Oxo-7-(6-oxo-1,4,5,6-tetrahydro-pyridazin-3-yl)-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester
  参考文献：
  名称：

  Syntheses and exploration of new biological activities in ethyl 6/7-substituted and 6, 7-disubstituted quinolin-4-one-3-carboxylates

  摘要：

  Syntheses of a number of ethyl 1H, 4H-quinolin-4-one-3-carboxylates carrying substituted piperidinedione ring at position 6 (25 & 31-35), tetrahydrofuranone (37) or tetraydropyridazinone ring (39) at position 7 and hydroxy and hydroxymethyl substituents at positions 6 and 7 respectively (41) of the quinolone ring, are reported here, of these compounds on the in vitro heme polymerase activity of Plasmodia and on the in vitro fungal growth are described.

  DOI：

  10.1016/0960-894x(95)00577-g
• 作为产物：
  描述：

  3-苯丙烯溴酸酯 在 盐酸 、 tin 、 硫酸 、 硝酸 、 sodium acetate 、 一水合肼 作用下， 以 甲醇 、 乙醇 、 水 为溶剂， 反应 6.0h， 生成 6-(3'-amino phenyl)-2,3,4,5-tetrahydro pyridazin-3-one
  参考文献：
  名称：

  Synthesis of Different Substituted Pyridazinone Derivatives and Their Anticonvulsant Activity

  摘要：

  6-苯基（3'-亚胺苯基）-2,3,4,5-四氢吡嗪-3-酮衍生物通过与不同醛反应从6-(3'-氨基苯基)-2,3,4,5-四氢吡嗪-3-酮合成。相应的吡嗪酮是由适当的β-(氨基苯基)丙酸与水合肼环化制备的。用MES（最大电击）法测试了吡嗪酮衍生物的抗惊厥活性，发现其中几种表现出显著的抗惊厥活性。

  DOI：

  10.1155/2011/873470

文献信息

• 6-Aryl-4,5-dihydro-3(2H)-pyridazinones. A new class of compounds with platelet aggregation inhibiting and hypotensive activities
  作者：M. Thyes、H. D. Lehmann、J. Gries、H. Koenig、R. Kretzschmar、J. Kunze、R. Lebkuecher、D. Lenke

  DOI：10.1021/jm00360a004

  日期：1983.6

  This paper reports on the synthesis and pharmacological activity of 6-aryl-4,5-dihydro-3(2H)-pyridazinone derivatives. The compounds exhibit an aggregation inhibiting action on human platelets in vitro and on rat platelets under ex vivo conditions, as well as a hypotensive action on rats. The strongest pharmacological effects were found with dihydropyridazinones, which have a 6-[p-[(chloroalkanoyl)amino]phenyl]

  本文报道了6-芳基-4,5-二氢-3（2H）-哒嗪酮衍生物的合成及其药理活性。所述化合物在体外和在离体条件下对人血小板表现出对人血小板的聚集抑制作用，以及对大鼠的降血压作用。发现具有6- [对-[（（氯代烷酰基）氨基]苯基]取代基以及在5-位具有甲基的二氢哒嗪酮具有最强的药理作用。这种类型的化合物在体外的抗聚集活性是乙酰水杨酸的高达16000倍，离体的抗聚集活性高达370倍。降压作用是比较物质二肼苯哒嗪的40倍。
• KUSASEH, YU.;MURAKATA, MASATOSI;MOTIDZUKI, NOBUO;TAKEHBAYASI, MITINORI
  作者：KUSASEH, YU.、MURAKATA, MASATOSI、MOTIDZUKI, NOBUO、TAKEHBAYASI, MITINORI

  DOI：——

  日期：——
• Syntheses and exploration of new biological activities in ethyl 6/7-substituted and 6, 7-disubstituted quinolin-4-one-3-carboxylates
  作者：Kamal Roy、Ranjan P. Srivastava、Babu L. Tekwani、Vikas C. Pandev、Amiva P. Bhaduri

  DOI：10.1016/0960-894x(95)00577-g

  日期：1996.1

  Syntheses of a number of ethyl 1H, 4H-quinolin-4-one-3-carboxylates carrying substituted piperidinedione ring at position 6 (25 & 31-35), tetrahydrofuranone (37) or tetraydropyridazinone ring (39) at position 7 and hydroxy and hydroxymethyl substituents at positions 6 and 7 respectively (41) of the quinolone ring, are reported here, of these compounds on the in vitro heme polymerase activity of Plasmodia and on the in vitro fungal growth are described.
• Synthesis of Different Substituted Pyridazinone Derivatives and Their Anticonvulsant Activity
  作者：Kartick Chandra Samanta、Mohd. Asif、Pooja、Vikas Garg、Priyanka Sharma、Ravinder Singh

  DOI：10.1155/2011/873470

  日期：——

  6-Phenyl(3᾽-imino-benzylidene)-2,3,4,5-tetrahydro pyridazin-3-one derivatives were synthesized from 6-(3᾽-aminophenyl)-2,3,4,5-tetrahydro pyridazin-3-one by reaction with different aldehydes. The respective pyridazinone was prepared by cyclization of appropriateβ-(aminophenyl) propionic acid with hydrazine hydrate. The pyridazinone derivatives were tested for anticonvulsant activity by MES (maximal electro shock) method and found that few of them have shown significant anticonvulsant activity.

  6-苯基（3'-亚胺苯基）-2,3,4,5-四氢吡嗪-3-酮衍生物通过与不同醛反应从6-(3'-氨基苯基)-2,3,4,5-四氢吡嗪-3-酮合成。相应的吡嗪酮是由适当的β-(氨基苯基)丙酸与水合肼环化制备的。用MES（最大电击）法测试了吡嗪酮衍生物的抗惊厥活性，发现其中几种表现出显著的抗惊厥活性。