2-methyl-4H-1-benzopyran-3-carboxylic acid benzyl ester | 1280677-71-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-methyl-4H-1-benzopyran-3-carboxylic acid benzyl ester
• 英文别名: benzyl 2-methyl-4H-chromene-3-carboxylate
• CAS: 1280677-71-5
• 化学式: C₁₈H₁₆O₃
• 分子量: 280.323
• InChiKey: JVISVMZTUXBDOG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  对甲苯磺酰氯 在 potassium phosphate 、 potassium hydroxide 、 copper(I) bromide 作用下， 以 乙醚 、 乙腈 为溶剂， 反应 27.0h， 生成 2-methyl-4H-1-benzopyran-3-carboxylic acid benzyl ester
  参考文献：
  名称：

  Assembly of 4H-chromenes, imidazobenzothiazines and quinazolines via copper-catalyzed domino reactions using 2-halobenzyl tosylates as substrates

  摘要：

  The use of 2-halobenzyl tosylates as substrates in copper-catalyzed domino intermolecular substitution/intramolecular arylation processes for the efficient and selective preparation of heterocycles is reported for the first time. Reaction of 2-halobenzyl tosylates with beta-ketoesters delivers 4H-chromenes with yields ranging between 59 and 89%. Imidazobenzothiazines are formed with yields up to 82% upon reaction of 2-halobenzyl tosylates with 2-mercaptoimidazoles. When 2-halobenzyl tosylates are reacted with benzamidines the corresponding quinazolines are obtained. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2014.06.071

文献信息

• Cu(I)-Catalyzed Domino Reactions: Efficient and Selective Synthesis of 4<i>H</i>-Chromenes and Naphthalenes
  作者：Chandi C. Malakar、Dietmar Schmidt、Jürgen Conrad、Uwe Beifuss

  DOI：10.1021/ol200347g

  日期：2011.4.15

  Depending on the ratio of the substrates and the reaction conditions, the Cu(I)-catalyzed domino reaction between bromobenzyl bromides and beta-ketoesters exclusively yields either 4H-chromenes or naphthalenes.
• Assembly of 4H-chromenes, imidazobenzothiazines and quinazolines via copper-catalyzed domino reactions using 2-halobenzyl tosylates as substrates
  作者：Mohamed A. Omar、Jürgen Conrad、Uwe Beifuss

  DOI：10.1016/j.tet.2014.06.071

  日期：2014.9

  The use of 2-halobenzyl tosylates as substrates in copper-catalyzed domino intermolecular substitution/intramolecular arylation processes for the efficient and selective preparation of heterocycles is reported for the first time. Reaction of 2-halobenzyl tosylates with beta-ketoesters delivers 4H-chromenes with yields ranging between 59 and 89%. Imidazobenzothiazines are formed with yields up to 82% upon reaction of 2-halobenzyl tosylates with 2-mercaptoimidazoles. When 2-halobenzyl tosylates are reacted with benzamidines the corresponding quinazolines are obtained. (C) 2014 Elsevier Ltd. All rights reserved.