2,2'-(2,2'-(2,2'-oxybis(ethan-2,1-diyl)bis(oxy))bis(ethan-2,1-diyl))diisoindolin-1,3-dione | 31255-14-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: 2,2'-(2,2'-(2,2'-oxybis(ethan-2,1-diyl)bis(oxy))bis(ethan-2,1-diyl))diisoindolin-1,3-dione
• 英文别名: 1,11-diphthalimido-3,6,9-trioxaundecane；N,N'-(3,6,9-trioxa-undecane-1,11-diyl)-bis-phthalimide；'Tetraethylenglykoldiphthalimid'；2-[2-[2-[2-[2-(1,3-dioxoisoindol-2-yl)ethoxy]ethoxy]ethoxy]ethyl]isoindole-1,3-dione
• CAS: 31255-14-8
• 化学式: C₂₄H₂₄N₂O₇
• mdl: MFCD00196081
• 分子量: 452.464
• InChiKey: UYVARKZPBLYEIH-UHFFFAOYSA-N

物化性质

• 熔点：
  104-105 °C
• 沸点：
  614.0±50.0 °C(Predicted)
• 密度：
  1.343±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  33
• 可旋转键数：
  12
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  102
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  2,2'-(2,2'-(2,2'-oxybis(ethan-2,1-diyl)bis(oxy))bis(ethan-2,1-diyl))diisoindolin-1,3-dione 在 盐酸 、 一水合肼 作用下， 以 乙醇 为溶剂， 生成 2-(壬基桥氧基)苯甲酸
  参考文献：
  名称：

  Bogatskii, A.V.; Luk'yanenko, N. G.; Kirichenko, T. I., Journal of Organic Chemistry USSR (English Translation), 1980, vol. 16, p. 1124 - 1129

  摘要：

  DOI：
• 作为产物：
  描述：

  三缩四乙二醇 在 吡啶 、 三溴化磷 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 2,2'-(2,2'-(2,2'-oxybis(ethan-2,1-diyl)bis(oxy))bis(ethan-2,1-diyl))diisoindolin-1,3-dione
  参考文献：
  名称：

  Bogatskii, A.V.; Luk'yanenko, N. G.; Kirichenko, T. I., Journal of Organic Chemistry USSR (English Translation), 1980, vol. 16, p. 1124 - 1129

  摘要：

  DOI：

文献信息

• Parallel vs. anti-parallel orientation in a curdlan/oligo(dA) complex as estimated by a FRET technique
  作者：Munenori Numata、Kazuya Koumoto、Masami Mizu、Kazuo Sakurai、Seiji Shinkai

  DOI：10.1039/b500156k

  日期：——

  We already found that β-1,3-glucan polysaccharides form polymeric complexes with certain polynucleotides, but the parallel vs. anti-parallel orientation in those complexes had remained unsolved. In this paper, this controversial problem has been discussed for curdlan/oligo(dA) complexes utilizing two different energy transfer techniques. The first system consists of a combination of fluorescein-labeled curdlan and 3′-(or 5′-)tetramethyl-rhodamine (TAMRA)-labeled oligo(dA). The second system utilizes gold nanoparticles: that is, two curdlan chains were linked by a disulfide bond and after complexation with oligo(dA), the complex was immobilized on gold nanoparticles. In this system, TAMRA was attached to the 3′ (or 5′) end of oligo(dA) and the gold particle acted as a fluorescence quencher (energy acceptor). These experiments have led us to conclude that in the curdlan/oligo(dA) complex, parallel orientation is more favourable than anti-parallel orientation. These findings have enabled us to envision a clearer image for the complexation mode between β-1,3-glucan polysaccharides and polynucleotides.

  我们已经发现β-1,3-葡聚糖多糖与某些多核苷酸形成聚合物复合物，但这些复合物中的平行与反平行取向问题仍未解决。在本文中，我们利用两种不同的能量转移技术讨论了酸乳杆菌素/寡核苷酸(dA)复合物这一有争议的问题。第一个系统由荧光素标记的酸乳杆菌素和3'（或5'）-四甲基罗丹明（TAMRA）标记的寡核苷酸(dA)组合而成。第二个系统则利用金纳米粒子：即通过二硫键连接两个酸乳杆菌素链，之后与寡核苷酸(dA)复合，复合物被固定在金纳米粒子上。在该系统中，TAMRA与寡核苷酸(dA)的3'（或5'）末端连接，金粒子则充当荧光猝灭剂（能量受体）。这些实验使我们得出结论，在酸乳杆菌素/寡核苷酸(dA)复合物中，平行取向比反平行取向更有利。这些发现让我们能够更清晰地构想β-1,3-葡聚糖多糖与多核苷酸之间的复合模式。
• The formation of complexes between aza-derivatives of crown ethers and primary alkylammonium salts. Part 2. Diaza-derivatives of metacyclophanes
  作者：Stephen J. Leigh、Ian O. Sutherland

  DOI：10.1039/p19790001089

  日期：——

  diazametacyclophanes (6) and the derivatives (15) have been synthesised and the formation of complexes between these host macrocycles and guest primary alkylammonium salts in CD2Cl2 has been examined using n.m.r. line-shape methods. In general the strengths of the complexes for any particular guest are in the order (6b) > (6c)(6a). A detailed examination of the complexes of (6b) shows that binding is

  已经合成了重氮叠氮环烷（6）和衍生物（15），并使用nmr线形方法研究了这些主体大环与CD 2 Cl 2中客体伯烷基铵盐之间的络合物的形成。通常，对于任何特定客人而言，复合物的强度为（6b）>（6c）（6a）。对（6b）配合物的详细检查表明，结合受到宾客与宿主之间的空间相互作用，宾客阳离子中某些额外官能团的存在以及宾客NH 3缺乏亲脂性屏蔽的不利影响团体。由衍生物（15）形成的复合物受含有官能团的侧链的影响，并且在某些情况下，结合能相对于由叠氮环戊烷（6b）形成的复合物显着增加。
• Synthesis of novel dansyl-labeled Celecoxib derivatives
  作者：Andreas Lill、Klaus Scholich、Holger Stark

  DOI：10.1016/j.tetlet.2013.09.025

  日期：2013.12

  Four novel dansyl-labeled derivatives of Celecoxib, a cyclooxygenase-2 (COX-2) selective inhibitor, were designed and synthesized. To realize the fluorophore-linker-approach divergent and convergent synthetic strategies were applied. Therefore Celecoxib p-benzoic acid, 8, was synthesized in a new and convenient way. The yield and the synthetic route to Celecoxib, 1, its pyrazolylic acid, 7, and its pyrazolylic methyl ester, 6, were improved. Through a convenient synthesis 1,11-diamino-3,6,9-trioxundecane, 19, was obtained in high yield and purity and used as a linker for the dansyl moiety. (C) 2013 Elsevier Ltd. All rights reserved.
• Structure of macrocyclic diamides of phthalic acid
  作者：Yu. G. Ganin、�. V. Ganin、Yu. A. Simonov、V. F. Anikin、G. L. Kamalov

  DOI：10.1007/bf00746542

  日期：——
• Interaction of N,N?-polyoxyethylenediphthalimides with diethylenetriamine and mass spectral behavior of the macrocyclic diamides of phthalic acid formed
  作者：�. V. Ganin、B. V. Rozynov、V. F. Anikin、G. L. Kamalov

  DOI：10.1007/bf00513567

  日期：1984.8