hydrogen-bonding complex of p-nitrophenol and imidazole | 53520-98-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: hydrogen-bonding complex of p-nitrophenol and imidazole
• 英文别名: 1H-imidazole;4-nitrophenol
• CAS: 53520-98-2
• 化学式: C₃H₄N₂*C₆H₅NO₃
• 分子量: 207.189
• InChiKey: WMPSLRTUNZRRHD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.71
• 重原子数：
  15
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  94.7
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  咪唑 、 4-硝基苯基乙酸酯 以 1,4-二氧六环 为溶剂， 生成 1-乙酰基咪唑 、 hydrogen-bonding complex of p-nitrophenol and imidazole
  参考文献：
  名称：

  摘要：

  The aminolysis reaction of 4-nitrophenyl acetate with imidazole was investigated in water, acetonitrile, propylene carbonate, and 1,4-dioxane at different temperatures, the observed rates can be evaluated with the help of a reaction mechanism consisting of two competitive reaction paths; the first is the bimolecular nucleophilic substitution of the phenol moiety by imidazole; the second path is performed via general base catalysis by a second imidazole molecule. The rate constants of the bimolecular reaction are quantitatively correlated with the four-parameter Taft-Kamlet equation for solvent effects on chemical reactions. A qualitative interpretation of the data shows that the two reaction paths are influenced to the same extent by the solvent.

  DOI：

  10.1023/a:1021706331026

文献信息

• Methods for treating autoimmune diseases in a subject and in vitro diagnostic assays
  申请人：——

  公开号：US20040067232A1

  公开（公告）日：2004-04-08

  The invention provides a method for treating an autoimmune disease in a subject by administering an interferon antagonist and a Flt3 ligand (Flt3L) antagonist. The invention also provides compositions containing one or more interferon antagonists, and one or more Flt3L antagonists, an in vitro assay for determining a subject's risk for developing an autoimmune disease, and kits for use, inter alia, with the assay.

  本发明提供了一种通过施用干扰素拮抗剂和Flt3配体（Flt3L）拮抗剂治疗受试者自身免疫性疾病的方法。本发明还提供了含有一种或多种干扰素拮抗剂和一种或多种Flt3L拮抗剂的组合物、用于确定受试者患自身免疫性疾病风险的体外检测方法，以及除其他外用于该检测方法的试剂盒。
• US7544357B2
  申请人：——

  公开号：US7544357B2

  公开（公告）日：2009-06-09