1-(吡啶-2-基)戊-1-醇 | 18085-83-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 1-(吡啶-2-基)戊-1-醇
• 英文名称: 1-(pyridin-2-yl)pentan-1-ol
• 英文别名: 1--pentanol-(1)；1-Pyridin-2-ylpentan-1-ol
• CAS: 18085-83-1
• 化学式: C₁₀H₁₅NO
• 分子量: 165.235
• InChiKey: FUGMSEMPEOMZSW-UHFFFAOYSA-N

物化性质

• 沸点：
  263.5±15.0 °C(Predicted)
• 密度：
  1.012±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  33.1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-(吡啶-2-基)戊-1-醇 在 间氯过氧苯甲酸 作用下， 以 二氯甲烷 为溶剂， 生成
  参考文献：
  名称：

  Enantioselective Addition of Nitromethane to 2-Acylpyridine N-Oxides. Expanding the Generation of Quaternary Stereocenters with the Henry Reaction

  摘要：

  The direct asymmetric Henry reaction with prochiral ketones, leading to tertiary nitroaldols, is an elusive reaction so far limited to a reduced number of reactive substrates such as trifluoromethyl ketones or alpha-keto carbonyl compounds. Expanding the scope of this important reaction, the direct asymmetric addition of nitromethane to 2-acylpyridine N-oxides catalyzed by a BOX-Cu(II) complex to give the corresponding pyridine-derived tertiary nitroaldols having a quaternary stereogenic center with variable yields and good enantioselectivity, is described.

  DOI：

  10.1021/ol500082d
• 作为产物：
  描述：

  2-氰基吡啶 在 sodium tetrahydroborate 、 碘 、 magnesium 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 生成 1-(吡啶-2-基)戊-1-醇
  参考文献：
  名称：

  Rhodium Catalyzed Asymmetric Hydrogenation of 2-Pyridine Ketones

  摘要：

  Catalyzed by [Rh(COD)Binapine]BF4, the asymmetric hydrogenation of 2-pyridine ketones has been achieved with excellent enantioselectivities (enantiomeric excesses up to 99%) under mild conditions. This method is suitable for various kinds of 2-pyridine ketones and their derivatives. A number of enantiomerically pure chiral 2-pyridine-aryl/alkyl alcohols were prepared through hydrogenation, which can be used directly in organic synthesis.

  DOI：

  10.1021/acs.orglett.5b01878

文献信息

• Perkin communication. Formation of secondary alcohols from the reaction of trimethyl- and methyldiphenyl-telluronium salts with aldehydes by use of organolithium reagents
  作者：Li-Lan Shi、Zhang-Lin Zhou、Yao-Zeng Huang

  DOI：10.1039/p19900002847

  日期：——

  The telluronium salts (1) and (2), precursors of the non-stabilized telluronium ylide, on treatment with organolithium reagents, reacted with aldehydes to afford secondary alcohols via tetraorganyl tellurium intermediates.

  在用有机锂试剂处理时，未稳定的碲化叶立德的前体碲盐（1）和（2）与醛反应，通过四有机基碲中间体得到仲醇。
• N-phosphinyl di-and tripeptides as renin inhibitors
  申请人：AMERICAN CYANAMID COMPANY

  公开号：EP0376040A2

  公开（公告）日：1990-07-04

  The invention is new renin inhibitor dipeptide and tripeptide derivatives of the formula:

  本发明是新的肾素抑制剂二肽和三肽衍生物，其化学式为
• PYRIDONE COMPOUND, AND AGRICULTURAL AND HORTICULTURAL FUNGICIDE HAVING THIS AS ACTIVE COMPONENT
  申请人：Mitsui Chemicals Agro, Inc.

  公开号：EP3611164A1

  公开（公告）日：2020-02-19

  Novel compounds controlling plant diseases are provided. Pyridone compounds of the invention are novel and can control plant diseases. The pyridone compounds of the invention encompass compounds of formula (1) and salts thereof.

  本发明提供了控制植物病害的新型化合物。本发明的吡啶酮化合物很新颖，可以控制植物病害。本发明的吡啶酮化合物包括式（1）化合物及其盐类。
• A remarkable effect of ionic liquids in transition-metal-free aerobic oxidation of benzylic alcohols
  作者：Yoshiro Oda、Koji Hirano、Tetsuya Satoh、Susumu Kuwabata、Masahiro Miura

  DOI：10.1016/j.tetlet.2011.08.053

  日期：2011.10

  The transition-metal-free aerobic oxidation of benzylic alcohols is uniquely accelerated by a 1-butyl-3-methylimidazolium hexafluorophosphate (BMI-PF(6))/PhCF(3) biphasic system and Cs(2)CO(3) to afford the corresponding ketones in good yields. The reaction system is also applicable to an oxidative cross-esterification of primary benzyl alcohols with a higher aliphatic alcohol. (C) 2011 Elsevier Ltd. All rights reserved.
• Chichibabin-Type Direct Alkylation of Pyridyl Alcohols with Alkyl Lithium Reagents
  作者：Jenna L. Jeffrey、Richmond Sarpong

  DOI：10.1021/ol3024117

  日期：2012.11.2

  Direct C(6) alkylation of pyridyl alcohols can be achieved following an initial deprotonation of the hydroxy group. This transformation, which is believed to occur by a Chichibabin-type alkylation, avoids lateral deprotonation prior to pyridine ring alkylation and gives increased regioselectivity for C(6) over C(4) alkylation.