3-amino-N-hydroxyphthalimide | 212557-14-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: 3-amino-N-hydroxyphthalimide
• 英文别名: 4-amino-N-hydroxyphthalimide；4-amino-2-hydroxyisoindole-1,3-dione
• CAS: 212557-14-7
• 化学式: C₈H₆N₂O₃
• 分子量: 178.147
• InChiKey: OCAPVBPLEUDUPS-UHFFFAOYSA-N

物化性质

• 沸点：
  466.2±47.0 °C(Predicted)
• 密度：
  1.749±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  83.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  对甲苯甲醚 、 3-amino-N-hydroxyphthalimide 在 氯仿 作用下， 反应 22.0h， 生成 4-甲氧基苯甲醛
  参考文献：
  名称：

  Process for the preparation of aldehydes and ketones

  摘要：

  一种制备乙烯基、炔基、芳基或杂芳基醛或乙烯基、炔基、芳基或杂芳基酮的方法，包括在介质和氧化剂的帮助下，通过反应乙烯基、炔基、芳基和杂芳基甲基和亚甲基化合物，其中介质选自脂肪族、杂环或芳香族NO或NOH含有的化合物组。

  公开号：

  US06297403B1
• 作为产物：
  描述：

  羟胺磷酸盐 、 3-氨基苯二甲酸 以 水 为溶剂， 生成 3-amino-N-hydroxyphthalimide
  参考文献：
  名称：

  Process for the preparation of cyclic N-hydroxydicarboximides

  摘要：

  该发明揭示了一种制备环状N-羟基二酰亚胺的方法，涉及将二元羧酸或其酐与羟胺盐在溶液中反应，无需进一步添加碱。

  公开号：

  US06316639B1
• 作为试剂：
  描述：

  对甲苯甲醚 在 3-amino-N-hydroxyphthalimide 、 laccase from Trametes versicolor 、 氧气 作用下， 以 水 为溶剂， 反应 22.0h， 以7%的产率得到4-甲氧基苄醇
  参考文献：
  名称：

  Synthesis of aromatic aldehydes by laccase-mediator assisted oxidation

  摘要：

  Aromatic aldehydes can be prepared in aqueous medium by oxidation of the corresponding methyl aromatic compounds in the presence of oxygen, the enzyme laccase and catalytic amounts of various N-hydroxy compounds. Allylic alcohols also gave the corresponding aldehydes in good yield. Competing reactions reveal that the N-hydroxy compound is involved in the rate determining step of the reaction; (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(98)01215-5

文献信息

• Method for oxidizing hydrocarbons
  申请人：——

  公开号：US20030176733A1

  公开（公告）日：2003-09-18

  The invention relates to a method for oxidizing substrates such as hydrocarbons, waxes or soot. The method involves the use of a compound of formula (I) in which: R1 and R2 represent H, an aliphatic or aromatic alkoxy radical, carboxyl radical, alkoxycarbonyl radical or hydrocarbon radical, each having 1 to 20 hydrocarbon atoms, SO3H, NH2, OH, F, Cl, Br, I and/or NO2, whereby R1 and R2 designate identical or different radicals or R1 and R2 can be linked to one another via a covalent bonding; Q1 and Q2 represent C, CH, N, CR5, each being the same or different; X and Z represent C, S, CH2, each being the same or different; Y represents O and OH; k=0, 1, 2; l=0, 1, 2; m=1 to 3, and; R5 represents one of the meanings of R1. Said compound is used as a catalyst in the presence of a radical initiator, whereby the molar ratio of the catalyst to the hydrocarbon is less than 10 mol %. Peroxy compounds or azo compounds can be used as the radical initiator. Preferred substrates are aliphatic or aromatic hydrocarbons.

  该发明涉及一种氧化底物（如烃、蜡或烟尘）的方法。该方法涉及使用式（I）的化合物，其中：R1和R2代表H、脂肪或芳香烷氧基基、羧基、烷氧羰基基或烃基，每个基有1到20个碳氢原子，SO3H、NH2、OH、F、Cl、Br、I和/或NO2，其中R1和R2表示相同或不同的基团，或者R1和R2可以通过共价键相连；Q1和Q2代表C、CH、N、CR5，每个基相同或不同；X和Z代表C、S、CH2，每个基相同或不同；Y代表O和OH；k=0、1、2；l=0、1、2；m=1到3；R5代表R1的一种含义。所述化合物作为催化剂在自由基引发剂存在下使用，其中催化剂与烃的摩尔比小于10mol％。过氧化物或偶氮化合物可用作自由基引发剂。首选底物为脂肪或芳香烃。
• [EN] DEHYDROGENATION OF CYCLOHEXANONE TO PRODUCE PHENOL<br/>[FR] DÉSHYDROGÉNATION DE CYCLOHEXANONE POUR PRODUIRE DU PHÉNOL
  申请人：EXXONMOBIL CHEM PATENTS INC

  公开号：WO2011096989A1

  公开（公告）日：2011-08-11

  In a process for the dehydrogenation of cyclohexanone to produce phenol, a feed comprising cyclohexanone is contacted with a dehydrogenation catalyst under dehydrogenation conditions comprising a temperature of less than 4000C and a pressure of less than 690 kPa, gauge, such 0.1 to 50 wt% of the cyclohexanone in said feed is converted to phenol and the dehydrogenation product contains less than 100 ppm by weight of alkylbenzenes.

  在将环己酮脱氢制备酚的过程中，与脱氢催化剂接触的进料包括环己酮，在脱氢条件下，包括温度低于400摄氏度和压力低于690千帕，绝对值，使得进料中的环己酮的0.1至50重量%转化为酚，而脱氢产物中含有的烷基苯低于100 ppm重量。
• [EN] PROCESS FOR PRODUCING PHENOL AND CYCLOHEXANONE<br/>[FR] PROCÉDÉ DE PRODUCTION DE PHÉNOL ET DE CYCLOHEXANONE
  申请人：EXXONMOBIL CHEM PATENTS INC

  公开号：WO2013165659A1

  公开（公告）日：2013-11-07

  In a process for separating a mixture comprising cyclohexanone and phenol, at least a portion of the mixture is distilled in the presence of a solvent including at least two alcoholic hydroxyl groups attached to non-adjacent saturated carbon atoms and at least one hemiketal defined by the formula (I) or the formula (II): [Formula I], [Formula II] wherein R1, the same or different at each occurrence, is independently an alkylene group having from 2 to 10 carbon atoms, R2 is an alkylene group having from 4 to 10 carbon atoms, and R3 is hydrogen or the following group: [Formula III] and/or an enol-ether derived from the hemiketal defined by the formula (I) or the formula (II), wherein the total concentration of the hemiketal and the enol-ether, expressed in terms of weight percentage on the basis of the total weight of the feed to the distilling step (a), is at least 0.01%.

  在分离包含环己酮和酚的混合物的过程中，至少混合物的一部分在存在包括至少两个连接到非相邻饱和碳原子的醇羟基的溶剂中蒸馏，并且至少存在由化学式(I)或化学式(II)定义的半缩醛：[化学式I]，[化学式II]其中R1，在每次出现时相同或不同，独立地是具有2至10个碳原子的烷基基团，R2是具有4至10个碳原子的烷基基团，R3是氢或以下基团：[化学式III]和/或由由化学式(I)或化学式(II)定义的半缩醛衍生的烯醇醚，其中半缩醛和烯醇醚的总浓度，以重量百分比的形式表示，基于蒸馏步骤(a)的进料的总重量，至少为0.01%。
• [EN] PROCESS FOR SEPARATING A MIXTURE COMPRISING CYCLOHEXANONE AND PHENOL<br/>[FR] PROCÉDÉ DE SÉPARATION D'UN MÉLANGE CONTENANT DE LA CYCLOHEXANONE ET DU PHÉNOL
  申请人：EXXONMOBIL CHEM PATENTS INC

  公开号：WO2013165656A1

  公开（公告）日：2013-11-07

  In a process for separating a mixture comprising cyclohexanone and phenol, at least a portion of the mixture is distilled in the presence of a solvent including at least two alcoholic hydroxyl groups attached to non-adjacent saturated carbon atoms, water, and in the presence or absence of a hemiketal defined by the formula (I) or the formula (II): wherein R1, the same or different at each occurrence, is independently an alkylene group having from 2 to 10 carbon atoms, R2 is an alkylene group having from 4 to 10 carbon atoms and/or R3 is hydrogen or the following group: and in the presence or absence of an enol-ether derived from the hemiketal defined by the formula (I) or the formula (II), wherein the total concentration of the hemiketal and enol-ether, expressed in term of weight percentage of the total weight of the feed to the distilling step, is at most 0.01%.

  在分离包含环己酮和酚的混合物的过程中，至少部分混合物在存在溶剂的情况下蒸馏，该溶剂包括连接到非相邻饱和碳原子上的至少两个醇羟基的水，以及存在或不存在由公式(I)或公式(II)定义的半缩酮：其中R1在每次出现时相同或不同地独立地是具有2至10个碳原子的烷基基团，R2是具有4至10个碳原子的烷基基团和/或R3是氢或以下基团：在存在或不存在由公式(I)或公式(II)定义的半缩酮衍生的烯醇醚的情况下，在蒸馏步骤的进料的总重量百分比方面，半缩酮和烯醇醚的总浓度最多为0.01%。
• [EN] PROCESS FOR PRODUCING SEC-BUTYLBENZENE<br/>[FR] PROCÉDÉ DE PRODUCTION DE SEC-BUTYLBENZÈNE
  申请人：EXXONMOBIL CHEM PATENTS INC

  公开号：WO2010042268A1

  公开（公告）日：2010-04-15

  In a process for producing sec-butylbenzene, a C4 olefinic hydrocarbon feedstock comprising isobutene and at least one n-butene is contacted with methanol and/or water in the presence of an acid catalyst to selectively oxygenate isobutene to produce an effluent stream rich in n-butene and containing less isobutene than the feedstock. The effluent stream is then contacted with benzene under alkylation conditions and in the presence of an alkylation catalyst to produce alkylation stream comprising sec-butylbenzene.

  在生产二丁基苯的过程中，将含有异丁烯和至少一种正丁烯的C4烯烃类烃原料与甲醇和/或水在酸催化剂的存在下接触，选择性地使异丁烯氧化，以产生富含正丁烯且含有比原料中更少异丁烯的流出流。然后，在烷基化条件下将流出流与苯接触，在烷基化催化剂的存在下生成含有二丁基苯的烷基化流。