benzyl N-(methoxymethyl) carbamate | 94471-35-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: benzyl N-(methoxymethyl) carbamate
• 英文别名: benzyl N-(methoxymethyl)carbamate；N-methoxymethyl benzyl carbamate；benzyl (methoxymethyl)carbamate；benzyl(methoxymethyl)carbamate；MeOCH2NHCbz；methoxymethyl-carbamic acid benzyl ester
• CAS: 94471-35-9
• 化学式: C₁₀H₁₃NO₃
• 分子量: 195.218
• InChiKey: OIAUXDRKTSQTDO-UHFFFAOYSA-N

物化性质

• 沸点：
  70 °C(Press: 0.001 Torr)
• 密度：
  1.122±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  47.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  benzyl N-(methoxymethyl) carbamate 在 四氯化钛 、 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 4.5h， 生成 [4R,8-dimethyl-2R-(4S-methyl-2-oxo-5R-phenyl-oxazolidine-3-carbonyl)-nonyl]-carbamic acid benzyl ester
  参考文献：
  名称：

  Combinations

  摘要：

  该瞬时发明涉及一种α-2-δ配体和AChE抑制剂的组合，用于治疗，特别是用于治疗疼痛，特别是神经病性疼痛的治疗。特别偏爱的α-2-δ配体是加巴喷丁和普雷加巴林。特别偏爱的ACHE抑制剂包括多奈哌齐（阿力普特®）、他克林（可格林®）、利伐司特（埃克洛尔®）、生理毒素（斯纳普通®）、加兰他明（瑞莫灵）、美曲磷（普罗美）、新斯的明（普罗斯的明）和伊科唑。

  公开号：

  US20050065176A1
• 作为产物：
  描述：

  N-苄氧羰基甘氨酸 在 甲醇 、 sodium methylate 作用下， 生成 benzyl N-(methoxymethyl) carbamate
  参考文献：
  名称：

  Linstead et al., Journal of the Chemical Society, 1951 <2854, 2856

  摘要：

  DOI：

文献信息

• [EN] BORON-CONTAINING RHO KINASE INHIBITORS<br/>[FR] INHIBITEURS DE LA RHO KINASE CONTENANT DU BORE
  申请人：PERCIPIAD INC

  公开号：WO2021011873A1

  公开（公告）日：2021-01-21

  The present invention provides boron-containing isoquinoline compounds as protein kinase-modulating compounds. These compounds are useful as neuroprotective and neuro-regenerative agents for the amelioration of glaucoma and other ocular neuropathies.

  本发明提供了含硼的异喹啉化合物作为蛋白激酶调节化合物。这些化合物可用作神经保护和神经再生剂，用于改善青光眼和其他眼神经病变。
• AMIDE DERIVATIVES HAVING MULTIMODAL ACTIVITY AGAINST PAIN
  申请人：ESTEVE PHARMACEUTICALS, S.A.

  公开号：EP3858439A1

  公开（公告）日：2021-08-04

  The present invention relates to new compounds that show pharmacological activity towards the subunit α2δ of voltage-gated calcium channels (VGCC), especially the α2δ-1 subunit of voltage-gated calcium channels or dual activity towards the subunit α2δ of voltage-gated calcium channels (VGCC), especially the α2δ-1 subunit of voltage-gated calcium channels, and the µ-opiod receptor (MOR or mu-opioid). The invention is also related to the process for the preparation of said compounds as well as to compositions comprising them, and to their use as medicaments.

  本发明涉及对电压门控钙通道（VGCC）的亚单位α2δ，特别是对电压门控钙通道的α2δ-1亚单位或对电压门控钙通道（VGCC）的亚单位α2δ以及µ-阿片受体（MOR或μ-阿片）显示药理活性的新化合物。该发明还涉及所述化合物的制备方法，以及包含它们的组合物，以及它们作为药物的用途。
• Synergistic combinations
  申请人：——

  公开号：US20040157847A1

  公开（公告）日：2004-08-12

  The instant invention relates to a combination of an alpha-2-delta ligand and a PDEV inhibitor for use in therapy, particularly in the curative, prophylactic or palliative treatment of pain, particularly neuropathic pain. Particularly preferred alpha-2-delta ligands are gabapentin and pregabalin. Particularly preferred PDEV inhibitors are sildenafil, vardenafil and tadalafil.

  这项瞬时发明涉及α-2-δ配体和PDEV抑制剂的组合，用于治疗，特别是在疼痛的治疗、预防或缓解中，特别是神经病性疼痛。特别偏好的α-2-δ配体是加巴喷丁和普雷加巴林。特别偏好的PDEV抑制剂是西地那非、伐地那非和他达拉非。
• An Unusual Presentation of Tarsal Tunnel Syndrome Caused by an Inflatable Ice Hockey Skate
  作者：B.V. Watson、H. Algahtani、R.J. Broome、J.D. Brown

  DOI：10.1017/s0317167100002274

  日期：2002.11

  Tarsal tunnel syndrome is a rare form of entrapment neuropathy. In athletes, it is usually the result of repetitive activity, local injury or a space-occupying lesion. Rarely, athletic footwear has been described as the primary cause of this syndrome.

  A 37-year-old male recreational hockey player was examined clinically and electrophysiologically because of spreading numbness in the toes of his left foot while playing hockey and wearing inflatable ice hockey skates designed to promote a better fit.

  Clinical and electrophysiological studies revealed evidence of left medial and lateral plantar nerve involvement. Reduced amplitudes of mixed and motor plantar nerve responses with fibrillation potentials and positive sharp waves and no evidence of conduction block suggest that the primary pathology was axonal loss. Follow-up examination showed significant clinical and electrophysiological improvement after the patient stopped wearing his inflatable ice hockey skates.

  We report an unusual case of tarsal tunnel syndrome caused by an inflatable ice hockey skate. The patient improved clinically and electrophysiologically when he stopped wearing the boot.

  背景：跗骨隧道综合征是一种罕见的局限性神经病。在运动员中，它通常是重复性活动、局部损伤或空间占位性病变的结果。方法：对一名 37 岁的男性休闲曲棍球运动员进行了临床和电生理学检查，原因是他在打曲棍球时左脚脚趾麻木，而他穿的充气冰上曲棍球冰鞋是为了更好地贴合脚部。混合性和运动性足底神经反应的振幅减小，并伴有颤动电位和正尖波，没有传导阻滞的证据，这表明主要病理变化是轴索缺失。随访检查显示，患者在停止穿着充气冰球冰鞋后，临床和电生理状况均有明显改善。结论：我们报告了一例因冰上曲棍球充气冰鞋引起的不寻常的跗骨隧道综合征，患者在停穿该冰鞋后，临床症状和电生理症状均有所改善。
• Stereoselective process for the synthesis of chiral garft compounds and intermediates
  申请人：Rahman Leera

  公开号：US20050085492A1

  公开（公告）日：2005-04-21

  The present invention describes a stereoselective preparation of derivatives and precursors of molecules having formula 1: Method of preparing the compounds, intermediates and derivatives are described. The methods described herein allow the preparation of diastereomeric forms of compound having formula 1. The compounds of the invention are GARFT inhibitors.

  本发明描述了具有化学式1的分子的立体选择性衍生物和前体的制备方法。描述了化合物、中间体和衍生物的制备方法。本文描述的方法允许制备具有化学式1的化合物的对映异构体形式。本发明的化合物是GARFT抑制剂。