4-溴-3-甲基-丁-1,2-二烯 | 71905-94-7

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 有机溴化物
• 中文名称: 4-溴-3-甲基-丁-1,2-二烯
• 英文名称: 1-Brom-2-methyl-butadien-(2,3)
• 英文别名: 4-Brom-3-methyl-butadien-(1,2)；1,2-Butadiene, 4-bromo-3-methyl-
• CAS: 71905-94-7
• 化学式: C₅H₇Br
• 分子量: 147.015
• InChiKey: VRVIVDAVWAXMCP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  6
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  4-溴-3-甲基-丁-1,2-二烯 在 barium dihydroxide 作用下， 以 溶剂黄146 为溶剂， 生成 2-methyl-2,3-butadiene-1-ol
  参考文献：
  名称：

  Traynard,J.-C., Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1960, vol. 250, p. 1504 - 1506

  摘要：

  DOI：
• 作为产物：
  描述：

  2-甲基-1-丁烯-3-炔 在 氢溴酸 作用下， 生成 4-溴-3-甲基-丁-1,2-二烯
  参考文献：
  名称：

  有机金属盐（M = Mg，Zn，Al）溴化衍生物α-烯类化合物：I.制备有机金属盐及其他可再活化的金属卤化物

  摘要：

  DOI：

  10.1016/s0022-328x(00)96157-6

文献信息

• Stereoselective preparation of methylenecyclobutane-fused angular tetracyclic spiroindolines via photosensitized intramolecular [2+2] cycloaddition with allene
  作者：Noriyoshi Arai、Takeshi Ohkuma

  DOI：10.1016/j.tetlet.2019.151252

  日期：2019.11

  Irradiation of 3-(hexa-4,5-dienyl)indole derivatives in the presence of 3',4'-dimethoxyacetophenone by a high-pressure mercury lamp through Pyrex glass gave the corresponding [2+2] cycloaddition products stereoselectively in high yields. The major product was a methylenecyclobutane-fused angular tetracyclic spiroindoline derivative produced by the [2+2] cycloaddition through a parallel orientation

  在3'，4'-二甲氧基苯乙酮的存在下，通过Pyrex玻璃用高压汞灯照射3-（六-4,5-二烯基）吲哚衍生物，以立体收率选择性地产生相应的[2 + 2]环加成产物。主要产物是由[2 + 2]环加成通过平行取向生成的亚甲基环丁烷稠合的角四环螺吲哚啉衍生物。次要产物是通过交叉取向的六氢甲氨基咔唑衍生物。吲哚氮上的吸电子取代基，例如酰基或烷氧基羰基适合于该反应。
• Aryl–Allene Cyclization via a Hg(OTf)₂-Catalytic Pathway
  作者：Hirofumi Yamamoto、Maho Ueda、Naoto Yamasaki、Akiyoshi Fujii、Ikuo Sasaki、Kazunobu Igawa、Yusuke Kasai、Hiroshi Imagawa、Mugio Nishizawa

  DOI：10.1021/acs.orglett.6b01144

  日期：2016.6.17

  Hg(OTf)2-catalyzed aryl–allene cyclization accompanied by formation of a quaternary carbon center has been realized. Deuterium-labeling experiments and computational modeling were used to propose a novel catalytic pathway involving direct H-transfer from the aromatic ring to the vinyl mercury moiety followed by mercury 1,2-migration.

  Hg（OTf）2催化的芳基-亚芳基环化反应伴随形成季碳中心。氘标记实验和计算模型被用来提出一种新颖的催化途径，涉及直接H从芳环到乙烯基汞部分的H转移，然后汞1,2-迁移。
• Traynard,J.-C., Bulletin de la Societe Chimique de France, 1962, p. 19 - 22
  作者：Traynard,J.-C.

  DOI：——

  日期：——
• Bertrand,M.; Le Gras,J., Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1963, vol. 257, p. 456 - 458
  作者：Bertrand,M.、Le Gras,J.

  DOI：——

  日期：——
• Preference to have used a medically supervised injecting centre among injecting drug users in Kings Cross, Sydney
  作者：Ingrid van Beek、Stuart Gilmour

  DOI：10.1111/j.1467-842x.2000.tb00507.x

  日期：2000.10

  Objective: To assess factors affecting preference to have last injected in a medically supervised injecting centre (MSIC) among injecting drug users (IDUs) attending a needle syringe program (NSP) in Kings Cross, Sydney. Methods: All NSP attenders over a two-day period in August 1999 were asked where they last injected, whether they injected alone and if they would have preferred to use an MSIC. This was in addition to the routine data collected, which included age, gender and last drug injected. Results: Among the 178 respondents, 52 (29%) last injected in a public place and 77 (44%) last injected alone. Seventy-one per cent of all respondents would have preferred to use an MSIC. Of those who injected in public, 83% would have preferred to use an MSIC compared to 66% of those who injected in private, which was significant (p = 0.03). Age, gender, last drug injected and having injected alone did not affect preference to use an MSIC. Conclusions: Respondents' high preference to use an MSIC suggests that it may well achieve its public order and public health objectives. Implications: An MSIC may significantly shift current patterns of illicit drug use in Kings Cross, the community impact of which should be monitored and managed.