1-(2,4,6-Trimethylphenyl)sulfonylpiperidine-4-carbonyl chloride | 1155861-37-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(2,4,6-Trimethylphenyl)sulfonylpiperidine-4-carbonyl chloride
• 英文别名: 1-(2,4,6-trimethylphenyl)sulfonylpiperidine-4-carbonyl chloride
• CAS: 1155861-37-2
• 化学式: C₁₅H₂₀ClNO₃S
• 分子量: 329.848
• InChiKey: XDJJPZQUKNXYED-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  62.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  异戊胺 、 1-(2,4,6-Trimethylphenyl)sulfonylpiperidine-4-carbonyl chloride 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 24.0h， 生成 N-isopentyl-1-(mesitylsulfonyl)piperidine-4-carboxamide
  参考文献：
  名称：

  POTENT NON-UREA INHIBITORS OF SOLUBLE EPOXIDE HYDROLASE

  摘要：

  本发明涉及通过抑制可溶性环氧合酶（sEH）的活性而具有血管舒张和抗炎效果的化合物。本发明还涉及识别此类化合物的方法，以及使用此类化合物治疗与血管舒张、炎症和/或内皮细胞功能障碍相关的疾病。特别是非限制性实施例中，发明的组成成分可用于治疗高血压。

  公开号：

  US20160052883A1
• 作为产物：
  描述：

  1-(Mesitylsulfonyl)piperidine-4-carboxylic acid 在 草酰氯 、 N,N-二甲基甲酰胺 作用下， 以 二氯甲烷 为溶剂， 反应 24.0h， 生成 1-(2,4,6-Trimethylphenyl)sulfonylpiperidine-4-carbonyl chloride
  参考文献：
  名称：

  Discovery of potent non-urea inhibitors of soluble epoxide hydrolase

  摘要：

  Soluble epoxide hydrolase (sEH) is a novel target for the treatment of hypertension and vascular inflammation. A new class of potent non-urea sEH inhibitors was identified via high throughput screening (HTS) and chemical modification. IC(50)s of the most potent compounds range from micromolar to low nanomolar. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.09.066

文献信息

• POTENT NON-UREA INHIBITORS OF SOLUBLE EPOXIDE HYDROLASE
  申请人：THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

  公开号：US20160052883A1

  公开（公告）日：2016-02-25

  The present invention relates to compounds that exhibit vasodilatory and anti-inflammatory effects by inhibiting the activity of soluble epoxide hydrolase (sEH). The present invention is also directed to methods of identifying such compounds, and use of such compounds for the treatment of diseases related to dysfunction of vasodilation, inflammation, and/or endothelial cells. In particular non-limiting embodiments, components of the invention may be used to treat hypertension.

  本发明涉及通过抑制可溶性环氧合酶（sEH）的活性而具有血管舒张和抗炎效果的化合物。本发明还涉及识别此类化合物的方法，以及使用此类化合物治疗与血管舒张、炎症和/或内皮细胞功能障碍相关的疾病。特别是非限制性实施例中，发明的组成成分可用于治疗高血压。
• Potent non-urea inhibitors of soluble epoxide hydrolase
  申请人：THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

  公开号：US10005732B2

  公开（公告）日：2018-06-26

  The present invention relates to compounds that exhibit vasodilatory and anti-inflammatory effects by inhibiting the activity of soluble epoxide hydrolase (sEH). The present invention is also directed to methods of identifying such compounds, and use of such compounds for the treatment of diseases related to dysfunction of vasodilation, inflammation, and/or endothelial cells. In particular non-limiting embodiments, components of the invention may be used to treat hypertension.

  本发明涉及通过抑制可溶性环氧化物水解酶（sEH）的活性而表现出扩张血管和抗炎作用的化合物。本发明还涉及鉴定此类化合物的方法，以及使用此类化合物治疗与血管扩张、炎症和/或内皮细胞功能障碍有关的疾病。在特别的非限制性实施方案中，本发明的成分可用于治疗高血压。
• Potent Non-Urea Inhibitors Of Soluble Epoxide Hydrolase
  申请人：Landry Donald W.

  公开号：US20120029022A1

  公开（公告）日：2012-02-02

  The present invention relates to compounds that exhibit vasodilatory and anti-inflammatory effects by inhibiting the activity of soluble epoxide hydrolase (sEH). The present invention is also directed to methods of identifying such compounds, and use of such compounds for the treatment of diseases related to dysfunction of vasodilation, inflammation, and/or endothelial cells. In particular non-limiting embodiments, components of the invention may be used to treat hypertension.
• US8653273B2
  申请人：——

  公开号：US8653273B2

  公开（公告）日：2014-02-18
• US9175285B2
  申请人：——

  公开号：US9175285B2

  公开（公告）日：2015-11-03