1-(mesitylsulfonyl)-N-(naphthalen-1-yl)piperidine-4-carboxamide | 640257-97-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-(mesitylsulfonyl)-N-(naphthalen-1-yl)piperidine-4-carboxamide
• 英文别名: N-naphthalen-1-yl-1-(2,4,6-trimethylphenyl)sulfonylpiperidine-4-carboxamide
• CAS: 640257-97-2
• 化学式: C₂₅H₂₈N₂O₃S
• 分子量: 436.575
• InChiKey: MQACUZOKJMWVDH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  31
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  74.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1-(2,4,6-Trimethylphenyl)sulfonylpiperidine-4-carbonyl chloride 、 1-萘胺 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 24.0h， 生成 1-(mesitylsulfonyl)-N-(naphthalen-1-yl)piperidine-4-carboxamide
  参考文献：
  名称：

  Discovery of potent non-urea inhibitors of soluble epoxide hydrolase

  摘要：

  Soluble epoxide hydrolase (sEH) is a novel target for the treatment of hypertension and vascular inflammation. A new class of potent non-urea sEH inhibitors was identified via high throughput screening (HTS) and chemical modification. IC(50)s of the most potent compounds range from micromolar to low nanomolar. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.09.066

文献信息

• Discovery of potent non-urea inhibitors of soluble epoxide hydrolase
  作者：Yuli Xie、Yidong Liu、Gangli Gong、Deborah H. Smith、Fang Yan、Alison Rinderspacher、Yan Feng、Zhengxiang Zhu、Xiangpo Li、Shi-Xian Deng、Lars Branden、Dušica Vidović、Caty Chung、Stephan Schürer、Christophe Morisseau、Bruce D. Hammock、Donald W. Landry

  DOI：10.1016/j.bmcl.2008.09.066

  日期：2009.4

  Soluble epoxide hydrolase (sEH) is a novel target for the treatment of hypertension and vascular inflammation. A new class of potent non-urea sEH inhibitors was identified via high throughput screening (HTS) and chemical modification. IC(50)s of the most potent compounds range from micromolar to low nanomolar. (C) 2008 Elsevier Ltd. All rights reserved.