2-氯-6-(苯基磺酰基)吡啶 | 100560-79-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-氯-6-(苯基磺酰基)吡啶
• 英文名称: 6-chloro-2-benzenesulfonyl-pyridine
• 英文别名: 2-chloro-6-(phenylsulfonyl)pyridine；2-(benzenesulfonyl)-6-chloropyridine
• CAS: 100560-79-0
• 化学式: C₁₁H₈ClNO₂S
• 分子量: 253.709
• InChiKey: OWQWDZHQWOYAGR-UHFFFAOYSA-N

物化性质

• 沸点：
  444.6±30.0 °C(Predicted)
• 密度：
  1.386±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  55.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-chloro-6-(phenylthio)pyridine 在 sodium hypochlorite 、 溶剂黄146 作用下， 反应 2.0h， 生成 2-氯-6-(苯基磺酰基)吡啶
  参考文献：
  名称：

  Green Chemical Synthesis of 2-Benzenesulfonyl-pyridine and Related Derivatives

  摘要：

  A practical synthesis of 2-benzenesulfonylpyridine, 1, is described which is a key starting material for the manufacture of an investigational new drug candidate at Eli Lilly and Company. An optimized green chemical process was developed which features a novel tandem SNAr/oxidation under mild conditions to produce the target sulfone, 1, in 86% yield and >99% purity. In addition, this novel, environmentally friendly methodology was found to be general for the synthesis of substituted aromatic pyridyl sulfides and sulfones.

  DOI：

  10.1021/op700060e

文献信息

• Metal-free catalyzed arylsulfonylation of chloroquinoline with sodium arylsulfinates under microwave irradiation
  作者：Xi-Yong Li、Ya-Min Sun、Jin-Wei Yuan

  DOI：10.1515/znb-2018-0007

  日期：2018.5.24

  An efficient protocol for the synthesis of 2-arylsulfonyl quinolines has been developed via a metal-free catalyzed cross-coupling reaction of chloroquinoline with sodium arylsulfinates in moderate-to-good yields under microwave irradiation. The reactions proceed with a wide range of substrates with good functional group tolerance.

  摘要：已经开发出一种高效的协议，通过金属催化的无金属交叉偶联反应，在微波辐射下以中等至良好的产率合成2-芳基磺酰基喹啉。反应可以在广泛的底物范围内进行，并具有良好的官能团容忍度。
• Process for producing 2-substituted pyridine derivative
  申请人：Koyakumaru Kenichi

  公开号：US20060041142A1

  公开（公告）日：2006-02-23

  The present invention provides a method of producing a pyridine derivative having a substituent at the 2-position of a heterocyclic structure conveniently and with fine selectivity. The present invention relates to a production method of a pyridine derivative having a substituent at the 2-position of a heterocyclic structure, which is represented by the formula (III), which includes reacting a 2-sulfonylpyridine derivative of the formula (I) with an organometallic compound of the formula (II) and the like, and the like: wherein each symbol is as defined in the Description.

  本发明提供了一种生产在杂环结构的 2 位上具有取代基的吡啶衍生物的方法，该方法简便且选择性好。本发明涉及一种在杂环结构的 2 位上具有取代基的吡啶衍生物的生产方法，该衍生物由式（III）表示，其中包括将式（I）的 2-磺酰基吡啶衍生物与式（II）的有机金属化合物等反应： 其中各符号如说明书中所定义。
• PROCESS FOR PRODUCING 2-SUBSTITUTED PYRIDINE DERIVATIVE
  申请人：KURARAY CO., LTD.

  公开号：EP1548005B1

  公开（公告）日：2011-04-13
• US7560563B2
  申请人：——

  公开号：US7560563B2

  公开（公告）日：2009-07-14
• [EN] CYANOPIPERIDINES<br/>[FR] CYANOPIPERIDINES
  申请人：SYNGENTA PARTICIPATIONS AG

  公开号：WO2001017965A2

  公开（公告）日：2001-03-15

  Compounds of general formula (I) wherein the substituents are defined as indicated in the claims, the preparation of these compounds, their usage in the control of pests, and intermediates in the preparation of the compounds, are described.