N-methyl-N-benzylisobutylamine | 68723-28-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-methyl-N-benzylisobutylamine
• 英文别名: benzyl-isobutyl-methyl-amine；Benzyl-isobutyl-methyl-amin；N-benzyl-N-isobutyl-N-methylamine；Benzyl iso-butyl methylamin；Benzyl-isobutyl-methylamin；N-benzyl-N,2-dimethylpropan-1-amine
• CAS: 68723-28-4
• 化学式: C₁₂H₁₉N
• mdl: MFCD16301778
• 分子量: 177.29
• InChiKey: SQSWACUMFXIPIF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N-methyl-N-benzylisobutylamine 、 2-isopropyl-5-methylcyclohexyl 2-iodoacetate 生成 benzyl-isobutyl-((1R)-menthyloxycarbonylmethyl)-methyl-ammonium; iodide
  参考文献：
  名称：

  Wedekind,E.; Wedekind,O., Chemische Berichte, 1908, vol. 41, p. 461

  摘要：

  DOI：
• 作为产物：
  描述：

  1-苯基-N-苯基甲氧基甲胺 在 吡啶硼烷 、 4-甲基苯磺酸吡啶 、 lithium iodide 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 甲醇 、 二氯甲烷 为溶剂， 反应 27.0h， 生成 N-methyl-N-benzylisobutylamine
  参考文献：
  名称：

  固体载体上叔胺的一般组合合成。基于氮无痕链的新型条件释放策略

  摘要：

  描述了叔胺的新型固相合成，该合成涉及碘引起的树脂结合的烷氧基铵中间体的N ＝ O键的裂解。通过顺序还原胺化然后进行烷基化来组装季中间体。通过碘离子或碱诱导从固相支持物上的裂解，从而以优异的纯度提供目标叔胺。

  DOI：

  10.1016/s0040-4039(00)01902-x

文献信息

• A one-pot synthesis of tertiary amines from amines, lactams and urethanes
  作者：H.L. Holland、G.B. Johnson

  DOI：10.1016/s0040-4039(01)95418-8

  日期：1979.1

  A one-pot synthesis of unsymmetrical tertiary amines from amides, lactams and urethanes has been developed. The reaction is general for all cases examined with the exception of N-aryl containing examples, which are not accessible by this method.

  已经开发了由酰胺，内酰胺和氨基甲酸酯一锅法合成不对称叔胺的方法。对于所检查的所有情况，该反应都是通用的，但含N-芳基的实例除外，该实例无法通过该方法进行操作。
• Cyanothiophene derivatives, compositions containing such compounds and methods of use
  申请人：——

  公开号：US20040097552A1

  公开（公告）日：2004-05-20

  The present invention addresses substituted cyanothiophene derivatives of the formula I: 1 as well as compositions containing such compounds and methods of treatment. The compounds in the present invention are glucagon antagonists. The compounds block the action of glucagon at its receptor and thereby decrease the levels of plasma glucose providing a treatment of diabetes.

  本发明涉及式I的取代氰基噻吩衍生物，以及含有这种化合物的组合物和治疗方法。本发明中的化合物是胰高血糖素拮抗剂。这些化合物阻断了胰高血糖素在其受体上的作用，从而降低血浆葡萄糖水平，提供糖尿病的治疗。
• Solid phase parallel synthesis of tertiary amines
  申请人：Andersson Carl-Magnus A.

  公开号：US06951958B1

  公开（公告）日：2005-10-04

  Described is method for preparing tertiary amines comprising sequential, exhaustive alkylation of a hydroxylamine derivative and cleavage of the O—N bond using the following steps: a) reacting the hydroxylamine derivative with an alkylating agent or with a carbonyl compound to form an oxime intermediate. b) reacting the oxime intermediate with a reducing agent to produce an alkylated derivative c) reacting the alkylated derivative with an alkylating agent or a carbonyl compound in the presence of a reducing agent to produce a dialkylated derivative d) reacting the dialkylated derivative with an alkylating agent to produce a quaternized derivative e) reacting the quaternized derivative with a reagent causing cleavage of the O—N bond to produce a tertiary amine.

  描述了一种制备三级胺的方法，包括以下步骤：a）将羟胺衍生物与烷基化试剂或羰基化合物反应，形成肟中间体；b）将肟中间体与还原剂反应，产生烷基化衍生物；c）在还原剂存在下，将烷基化衍生物与烷基化试剂或羰基化合物反应，产生二烷基化衍生物；d）将二烷基化衍生物与烷基化试剂反应，产生季铵化衍生物；e）将季铵化衍生物与引起O-N键断裂的试剂反应，产生三级胺。
• USE OF SUBSTITUTED BENZODIAZEPINONES AND BENZAZEPINONES OR THE SALTS THEREOF AS ACTIVE SUBSTANCES AGAINST ABIOTIC PLANT STRESS
  申请人：BAYER CROPSCIENCE AG

  公开号：US20150218110A1

  公开（公告）日：2015-08-06

  The use of substituted benzodiazepinones and benzazepinones of the general formula (I) or salts thereof where the radicals in the general formula (I) correspond to the definitions given in the description, for enhancing stress tolerance in plants to abiotic stress, for strengthening plant growth and/or for increasing plant yield, and to selected processes for preparing the compounds mentioned above.

  使用通式（I）或其盐的取代苯二氮平酮和苯并氮平酮，其中通式（I）中的基团对应于描述中给出的定义，用于增强植物对非生物胁迫的耐受性，加强植物生长和/或增加植物产量，并选择上述化合物的制备过程。
• Gonadotropin-releasing hormone receptor antagonists and methods relating thereto
  申请人：Zhu Yun-Fei

  公开号：US20070208049A1

  公开（公告）日：2007-09-06

  GnRH receptor antagonists are disclosed that have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure: wherein A, Q, R 1 , R 2 , R 3a , R 3b , R 4 , R 5 , R 6 and n are as defined herein, including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.

  本发明揭示了GnRH受体拮抗剂，其在治疗男女性激素相关疾病方面具有用途。本发明的化合物具有以下结构：其中A、Q、R1、R2、R3a、R3b、R4、R5、R6和n的定义如本文所述，包括立体异构体、前药和其药学上可接受的盐。本发明还揭示了含有本发明化合物与药学上可接受的载体组合的组合物，以及与其相关的方法，用于在需要时对抗促性腺激素释放激素。