(氨基亚甲基)丙二腈 | 672-25-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: (氨基亚甲基)丙二腈
• 英文名称: aminomethylene-malononitrile
• 英文别名: 2-(aminomethylene)malononitrile；Aminomethylen-malononitril；(aminomethylene)-propanedinitrile；2-aminomethylene-malononitrile；aminomethylene malononitrile；3-amino-2-cyanoacrylonitril；(Aminomethylene)malononitrile；2-(aminomethylidene)propanedinitrile
• CAS: 672-25-3
• 化学式: C₄H₃N₃
• mdl: MFCD19159549
• 分子量: 93.0879
• InChiKey: RIOQOLSODGFOQV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  7
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  73.6
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2926909090

反应信息

• 作为反应物：
  描述：

  (氨基亚甲基)丙二腈 在 五氯化磷 作用下， 以 氯苯 为溶剂， 生成 2,2,4-trichloro-2λ⁵-[1,3,2]diazaphosphinine-5-carbonitrile
  参考文献：
  名称：

  Kornuta,P.P. et al., Journal of general chemistry of the USSR, 1971, vol. 41, p. 2416 - 2421

  摘要：

  DOI：
• 作为产物：
  描述：

  三氰甲烷 在 palladium on activated charcoal 氢气 作用下， 以 乙醚 、 水 、 溶剂黄146 为溶剂， 生成 (氨基亚甲基)丙二腈
  参考文献：
  名称：

  Dicyanoketenimine (Cyanoform) and Its Reduction Products

  摘要：

  DOI：

  10.1021/jo01045a063

文献信息

• 3-(5-carboxy-4-substituted-phenyl)-(thio)uracil-esters and salts
  申请人：Hoffmann-La Roche Inc.

  公开号：US04746352A1

  公开（公告）日：1988-05-24

  The disclosure is concerned with novel 3-aryluracils of the formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6 and X have the significances given in the description, as well as salts thereof and their manufacture, weed control compositions which contain such compounds as active ingredients and the use of the active ingredients or compositions for the control of weeds. The disclosure also concerns certain herbicidally active starting materials and weed control compositions containing these as active ingredients.

  本公开涉及新颖的3-芳基尿嘧啶，其化学式为##STR1##其中R.sup.1、R.sup.2、R.sup.3、R.sup.4、R.sup.5、R.sup.6和X的含义如描述中所示，以及它们的盐和制备方法，含有这些化合物作为活性成分的除草剂组合物，以及利用这些活性成分或组合物来控制杂草。本公开还涉及某些具有除草活性的起始材料和含有这些起始材料作为活性成分的除草剂组合物。
• Oxidative peptide bond formation of glycine–amino acid using 2-(aminomethyl)malononitrile as a glycine unit
  作者：Xiaoling Wang、Jing Li、Yujiro Hayashi

  DOI：10.1039/d1cc00130b

  日期：——

  of glycine–amino acid was synthesized by coupling of substituted 2-(aminomethyl)malononitrile as a C-terminal glycine unit and N-terminal amine using CsOAc and O2 in an aqueous solution. This is a coupling reagent-free and catalyst-free peptide synthesis via oxidative amide bond formation. Various tripeptides and tetrapeptides were synthesized efficiently and the sulfide moiety is inert even under

  甘氨酸-氨基酸的酰胺键是通过在水溶液中使用CsOAc和O 2偶联取代的2-（氨基甲基）丙二腈作为C末端甘氨酸单元和N末端胺而合成的。这是通过氧化酰胺键形成的无偶联试剂和无催化剂的肽合成。有效地合成了各种三肽和四肽，并且即使在氧气气氛下，硫化物部分也是惰性的。
• 3-fluoropyridyl-2-oxy-phenoxy derivatives having herbicidal activity
  申请人：Ciba-Geigy Corporation

  公开号：US04740235A1

  公开（公告）日：1988-04-26

  There are described novel 3-fluoropyridyl-2-oxy derivatives having a herbicidal action and an action reducing the growth of grasses, which compounds correspond to the formula I ##STR1## wherein X is halogen or the trifluoromethyl group, and Z is an alkanoic acid derivative which is more precisely described in the specification. These compounds are suitable for the selective control of weeds in crops of cultivated plants, or for the reduction of the growth of grasses.

  描述了一种新型的3-氟吡啶-2-氧衍生物，具有除草作用和减缓草本植物生长的作用，这些化合物对应于公式I：##STR1##其中X是卤素或三氟甲基基团，Z是更详细地在说明书中描述的烷基酸衍生物。这些化合物适用于选择性地控制农作物中的杂草或减缓草本植物的生长。
• Studies on pyrimidine derivatives. VIII. Ring-cleavage reaction of 4,6-dimethylpyrimidine 1-oxide.
  作者：HIROSHI YAMANAKA、TAKAO SAKAMOTO、YUMI BANNAI、SHIGERU OGAWA

  DOI：10.1248/cpb.26.3404

  日期：——

  Unlike quinoline and isoquinoline N-oxides, 4, 6-dimethylpyrimidine 1-oxide reacted with active methylene compounds such as malononitrile, ethyl cyanoacetate, and ethyl ethoxycarbonylacetimidate to give ring-opened products. In these cases, none of pyrimidine derivatives with a substituent at the 2-position were isolated. On the other hand, the pyrimidine 1-oxide was condensed with 5-amino-3-methyl-isoxazole to give 2-(5-amino-3-methyl-4-isoxazolyl)-4, 6-dimethylpyrimidine. Comparing these two reactions, the driving force of the ring-fission of the reaction intermediates was discussed.

  与喹啉和异喹啉 N-氧化物不同，4,6-二甲基嘧啶 1-氧化物与丙二腈、氰乙酸乙酯和乙氧羰基乙酰亚胺等活性亚甲基化合物发生反应，生成开环产物。在这些情况下，没有分离出 2 位上有取代基的嘧啶衍生物。另一方面，嘧啶 1-氧化物与 5-氨基-3-甲基异恶唑缩合，得到 2-（5-氨基-3-甲基-4-异恶唑基）-4, 6-二甲基嘧啶。对比这两个反应，讨论了反应中间体环裂变的驱动力。
• Synthesis of conjugated ?-dimethylaminocarbonyl compounds containing an azomethine fragment
  作者：Zh. A. Krasnaya、V. S. Bogdanov

  DOI：10.1007/bf00963505

  日期：1991.10

  Methods have been studied for synthesis of conjugated omega-dimethylaminocarbonyl compounds containing an azomethine fragment. The structures were established of all products from reaction of 2-aza-3-dimethylaminoacrolein acetal with CH-acids and of DMF acetal and beta-dimethylaminoacrolein aminal with primary amines. It was shown that in many cases these reactions are accompanied by cleavage of the C=N, C-N and C=C bonds.