3-(pyridin-2-yl)pyridazine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 3-(pyridin-2-yl)pyridazine
• 英文别名: 3-(2-pyridyl)pyridazine；2'-pyridylpyridazine；3-(pyridine-2-yl)pyridazine；Pyridylpyridazine；3-pyridin-2-ylpyridazine
• 化学式: C₉H₇N₃
• 分子量: 157.175
• InChiKey: PPERRAQNUGHXMH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  38.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-(pyridin-2-yl)pyridazine 、 (NEt4)2[rhenium(I)(bromide)3(carbonyl)3] 以 甲醇 为溶剂， 以87%的产率得到[ReBr(CO)₃(2-(pyridin-2-yl)pyridazine)]
  参考文献：
  名称：

  杂联芳基配体对[ReINCS(NᴖN)(CO)3]型光敏剂光电化学性质的影响

  摘要：

  提供了一套完整的对称双二嗪 (bdz) 和不对称吡啶基二嗪 (pydz) 配体，以及已知的 2,2'-联吡啶 (bpy) 配体，以及它们各自的铼 (I)-三羰基-溴和-硫氰化配合物. 由于基于二亚胺的 LUMO 的稳定性，随着氮原子数量的增加，观察到红移。正如能隙定律所预期的那样，这导致沿 bpy-pydz-bdz 线的非辐射衰减常数 (knr) 增加。有趣的是，与其他 pydz 配体（2-（吡啶-2-基）哒嗪（pypdz）和 3,3'-联哒嗪（bpdz））相比，两种哒嗪配体的 knr 增加并不明显。bdz 配体。这导致整体寿命和量子产率更长，

  DOI：

  10.1002/ejic.201900652
• 作为产物：
  描述：

  3-氯-6-(2-吡啶基甲基)哒嗪 在 四(三苯基膦)钯 六正丁基二锡 作用下， 以 乙二醇二甲醚 为溶剂， 以12%的产率得到3-(pyridin-2-yl)pyridazine
  参考文献：
  名称：

  Pyridazine and Pyrrole Compounds, Processes For Obtaining Them and Uses

  摘要：

  本发明涉及非线性寡吡啶化合物，以及获得它们的方法，它们的用途，以及将它们还原为寡吡咯和所获得的吡啶基吡咯和寡吡咯化合物的用途。该发明特别涉及用作药物的用途，特别是用于治疗癌症、细菌感染或寄生虫感染等病理的用途，以及在材料、环境、电子和光学领域的用途。

  公开号：

  US20100298562A1

文献信息

• LINEAR PYRIDAZINE AND PYRROLE COMPOUNDS, METHOD FOR OBTAINING THEM AND APPLICATIONS
  申请人：Dubreuil Didier Max

  公开号：US20100004443A1

  公开（公告）日：2010-01-07

  The present invention relates to linear pyridazine compounds, and more particularly to those of these compounds which are oligopyridazine compounds, to processes for obtaining them, to their uses, and also to their reduction to pyrroles and to the uses of the pyrrole, pyridazinylpyrrole and oligopyrrole compounds obtained. The invention relates in particular to the uses as medicaments, in particular for treating pathologies such as cancer, bacterial infections or parasitic infections, and also the applications in the materials, environmental, electronics and optics field.

  本发明涉及线性吡啶二氮杂环化合物，更特别涉及这些化合物中的寡吡啶二氮杂环化合物，以及获取它们的方法、它们的用途，以及它们还原为吡咯并利用所得的吡咯、吡啶二氮杂吡咯和寡吡咯化合物的用途。本发明特别涉及作为药物的用途，特别是用于治疗癌症、细菌感染或寄生虫感染等病理情况，以及在材料、环境、电子和光学领域的应用。
• INHIBITORS OF COLLAGEN PROLYL 4-HYDROXYLASE
  申请人：WISCONSIN ALUMNI RESEARCH FOUNDATION

  公开号：US20160280701A1

  公开（公告）日：2016-09-29

  Biheteroaryl dicarboxylates and esters, and salts thereof which are useful as modulators of CP4H activity and more particularly as inhibitors of CP4H. Compounds of formula: and salts thereof where: X is S, O, NH, or NR, where R is an alkyl group having 1-3 carbon atoms; R 1 and R 2 independently are —OR 7 , or —NHSO 2 R 8 , where R 7 is selected from: hydrogen, alkyl, alkenyl, alkoxyalkyl, —R′—CO—R″, —R′—CO—O—R″, —CO—R″, —R′—O—CO—R″, —R′—CO—NR″, —CO—NR″, or —R′—O—CO—NR″, and R 8 is selected from hydrogen, alkyl, aryl, arylalkyl; R 3 , R 4 and R 6 independently are hydrogen, alkyl, alkoxy, alkenyl, alkenoxy, halo alkyl, haloalkenyl, halogen, hydroxyl, hydroxyalkyl, hydroxyalkenyl, aryl, aryloxy, arylalkyl or arylalkyloxy; R 5 is hydrogen, halogen, alkyl having 1-3 carbon atoms, or alkoxy having 1-3 carbon atoms; —R′— is a divalent straight chain or branched alkylene, and —R″ is an alkyl, alkenyl, arylalkyl, or aryl group. Methods for inhibition of CP4H in vivo and in vitro.

  Biheteroaryl二羧酸酯和酯，以及它们的盐，可用作CP4H活性的调节剂，更具体地作为CP4H的抑制剂。化合物的结构式:及其盐，其中:X为S、O、NH或NR，其中R为具有1-3个碳原子的烷基基团；R1和R2独立地为—OR7，或—NHSO2R8，其中R7选自：氢、烷基、烯基、烷氧基烷基、—R′—CO—R″、—R′—CO—O—R″、—CO—R″、—R′—O—CO—R″、—R′—CO—NR″、—CO—NR″或—R′—O—CO—NR″，而R8选自氢、烷基、芳基、芳基烷基；R3、R4和R6独立地为氢、烷基、烷氧基、烯基、烯氧基、卤代烷基、卤代烯基、卤素、羟基、羟基烷基、羟基烯基、芳基、芳氧基、芳基烷基或芳基烷氧基；R5为氢、卤素、具有1-3个碳原子的烷基，或具有1-3个碳原子的烷氧基；—R′—为二价的直链或支链烷基，而—R″为烷基、烯基、芳基烷基或芳基。用于体内和体外抑制CP4H的方法。
• Pharmaceutical composition for treatment of cancer containing pyridylpyridazine or transition metal complex thereof as active ingredient
  申请人：Sung Nack-Do

  公开号：US20090036418A1

  公开（公告）日：2009-02-05

  The present invention relates to a pharmaceutical composition for the treatment of cancer, which contains, as an active ingredient, a pyridylpyridazine compound or a transition metal complex thereof. As described above, the pyridylpyridazine compounds according to the present invention and the transition metal complexes thereof have anticancer activity and can be easily prepared at low cost. Thus, these compounds are useful as anticancer agents against various cancers, including lung cancer, adenocarcinoma, skin cancer, colon cancer, uterine cancer and brain cancer, which are expressed due to immune system abnormality.

  本发明涉及一种用于治疗癌症的药物组合物，其包含作为活性成分的吡啶基吡嗪化合物或其过渡金属配合物。如上所述，根据本发明，吡啶基吡嗪化合物及其过渡金属配合物具有抗癌活性，并且可以以低成本轻松制备。因此，这些化合物对包括肺癌、腺癌、皮肤癌、结肠癌、子宫癌和脑癌在内的各种癌症具有抗癌作用，这些癌症是由于免疫系统异常表达的。
• Colorless ligand-releasing monomers and polymers and their use to provide dyes with metal ions
  申请人：EASTMAN KODAK COMPANY (a New Jersey corporation)

  公开号：EP0186869A2

  公开（公告）日：1986-07-09

  Essentially colorless, hydrophilic ligand-releasing polymers are prepared from ethylenically unsaturated polymerizable monomers represented by the structure: wherein R' is hydrogen or lower alkyl, COUP is a photographic color coupling moiety, LINK is a coupling-off group which can be cleaved by an oxidized developer composition, and LIG is a ligand capable of complexing with metal ions, while joined to the polymer, to form a dye. These polymers also have recurring units which impart hydrophilicity to the polymer. These polymers form metal complex dyes in unexposed areas of photographic elements only, while the ligand is cleaved from the polymer in the exposed areas and washed out of the element.

  基本无色的亲水配体释放聚合物是由结构如下的乙烯不饱和可聚合单体制备的： 其中，R' 是氢或低级烷基，COUP 是感光颜色偶联基团，LINK 是可被氧化显影组合物裂解的偶联基团，LIG 是能与金属离子络合形成染料的配体。这些聚合物还具有可赋予聚合物亲水性的循环单元。这些聚合物只在感光元件的未暴露区域形成金属络合染料，而配体则在暴露区域从聚合物中裂解并被冲出感光元件。
• Analytical compositions, elements and methods utilizing reduction of ferric ion chelates to form detectable dyes
  申请人：EASTMAN KODAK COMPANY (a New Jersey corporation)

  公开号：EP0198286A2

  公开（公告）日：1986-10-22

  @ Ferric ion chelates are useful in analytical compositions, elements and methods for the determination of reductants, or other analytes which can react to produce a reductant. The ferric ion chelate is reduced to ferrous ion and ferric ion coordinating ligand. The ferrous ions then coordinate with a suitable ferrous ion coordinating ligand to form a colored complex. In particular, these compositions and elements are useful for detecting nicotinamide adenine dinucleotide, reduced form or nicotinamide adenine dinucleotide phosphate, reduced form, or an analyte (e.g. an enzyme) which produces the reduced forms of nucleotide in biological fluids.

  铁离子螯合物适用于测定还原剂或其他可反应生成还原剂的分析物的分析成分、元素和方法。铁离子螯合物被还原成亚铁离子和铁离子配位配体。然后，亚铁离子与合适的亚铁离子配位配体配位，形成有色复合物。特别是，这些组合物和元素可用于检测生物液体中还原型烟酰胺腺嘌呤二核苷酸或还原型烟酰胺腺嘌呤二核苷酸磷酸酯或产生还原型核苷酸的分析物（如酶）。