1-morpholino-1,3-dihydro-7-(dimethylcarbamoyloxy)-6-methylfuro(3,4-c)pyridine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 1-morpholino-1,3-dihydro-7-(dimethylcarbamoyloxy)-6-methylfuro(3,4-c)pyridine
• 英文别名: (6-methyl-1-morpholin-4-yl-1,3-dihydrofuro[3,4-c]pyridin-7-yl) N,N-dimethylcarbamate
• 化学式: C₁₅H₂₁N₃O₄
• 分子量: 307.349
• InChiKey: MKGQNFIKWWYCAM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  64.1
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  二甲氨基甲酰氯 、 1-morpholino-6-methyl-1,3-dihydrofuro[3,4-c]pyridin-7-ol 在 potassium carbonate 作用下， 以 丙酮 为溶剂， 反应 2.0h， 生成 1-morpholino-1,3-dihydro-7-(dimethylcarbamoyloxy)-6-methylfuro(3,4-c)pyridine
  参考文献：
  名称：

  Therapeutics for cardiovascular and related diseases

  摘要：

  吡啶醛类似物可以用于治疗B6缺乏及相关疾病；心血管及相关疾病；黑色素瘤及相关疾病；以及相关症状。其中一种类似物是符合以下结构式的化合物：或其药学上可接受的酸盐，其中R1为烷基、烯基，其中烷基或烯基可以被氮、氧或硫中断，并且可以在末端碳上被羟基、烷氧基、烷酰氧基、烷酰氧基芳基、烷氧基烷酰基、烷氧基羰基、或二烷基氨基氧基取代；烷氧基；二烷基氨基；烷酰氧基；烷酰氧基芳基；烷氧基烷酰基；烷氧基羰基；二烷基氨基氧基；或芳基、芳基氧基、芳基硫基、或芳基烷基，其中芳基可以被烷基、烷氧基、氨基、羟基、卤素、硝基、或烷酰氧基取代。这些类似物可以单独或与已知药物同时使用，用于治疗上述疾病。

  公开号：

  US06339085B1

文献信息

• Pyridoxal analogues for the treatment of disorders caused by a deficiency in vitamin B6
  申请人：Medicure International Inc.

  公开号：EP1640005A2

  公开（公告）日：2006-03-29

  Pyridoxal analogues can be useful for treating B6 deficiency and related diseases; cardiovascular and related diseases; melanoma and related diseases; and symptoms thereof. The analogues have formula (V) or a pharmaceutically acceptable acid addition salt thereof, in which R1 is alkyl, alkenyl, in which alkyl or alkenyl can be interrupted by nitrogen, oxygen, or sulfur, and can be substituted at the terminal carbon by hydroxy, alkoxy, alkanoyloxy, alkanoyloxyaryl, alkoxyalkanoyl, alkoxycarbonyl, or dialkylcarbamoyloxy; alkoxy; dialkylamino; alkanoyloxy; alkanoyloxyaryl; alkoxyalkanoyl; alkoxycarbonyl; dialkylcarbamoyloxy; or aryl, aryloxy, arylthio, or aralkyl, in which aryl can be substituted by alkyl, alkoxy, amino, hydroxy, halo, nito, or alkanoyloxy. R<2> is secondary amine. These analogues can be administered, either alone or concurrently with known medications, to treat the above-described diseases.

  吡哆醛类似物可用于治疗 B6 缺乏症和相关疾病、心血管疾病和相关疾病、黑色素瘤和相关疾病及其症状。这些类似物具有式（V）或其药学上可接受的酸加成盐，其中 R1 是烷基、烯基，其中烷基或烯基可以被氮、氧或硫中断，并且可以在末端碳上被羟基、烷氧基、烷酰氧基、烷酰氧基芳基、烷氧基烷酰基、烷氧基羰基或二烷基氨基甲酰氧基取代；烷氧基；二烷基氨基；烷酰氧基；烷酰氧基芳基；烷氧基烷酰基；烷氧羰基；二烷基氨基甲酰氧基；或芳基、芳氧基、芳硫基或芳烷基，其中芳基可被烷基、烷氧基、氨基、羟基、卤代、硝基或烷酰氧基取代。R 是仲胺。这些类似物可单独使用或与已知药物同时使用，以治疗上述疾病。
• use of pyridoxal phosphate for the treatment of diabetes and related complications
  申请人：Medicure Inc.

  公开号：EP1832291A2

  公开（公告）日：2007-09-12

  Use of pyridoxal-5'-phosphate, a pharmaceutically acceptable acid addition salt thereof, or a mixture thereof for the preparation of a medicament for treating insulin-dependent or non-insulin-dependent diabetes mellitus, related conditions, symptoms of insulin-dependent or non-insulin-dependent diabetes mellitus, or related conditions, or any combination thereof in a mammal.

  吡哆醛-5'-磷酸、其药学上可接受的酸加成盐或其混合物用于制备治疗哺乳动物的胰岛素依赖型或非胰岛素依赖型糖尿病、相关病症、胰岛素依赖型或非胰岛素依赖型糖尿病症状或相关病症或其任何组合的药物。
• Treatment of cardiovascular and related pathologies
  申请人：Medicure International Inc.

  公开号：EP1872797A2

  公开（公告）日：2008-01-02

  Use of a compound selected from: pyridoxal-5'-phosphate, pyridoxal, pyridoxamine, 3-acylated pyridoxal analogues, pharmaceutically acceptable acid addition salts thereof, and mixtures thereof, in the preparation of a medicament for the treatment of cardiovascular and related diseases in a mammal undergoing concurrent treatment with an angiotensin II receptor antagonist. The cardiovascular and related diseases include ischemia, congestive heart failure, hypertrophy, ischemia reperfusion injury, and myocardial ischemia reperfusion injury.

  一种选自下列物质的化合物在制备治疗同时接受血管紧张素II受体拮抗剂治疗的哺乳动物的心血管疾病和相关疾病的药物中的用途：吡哆醛-5'-磷酸、吡哆醛、吡哆胺、3-酰化吡哆醛类似物、其药学上可接受的酸加成盐及其混合物。心血管疾病和相关疾病包括缺血、充血性心力衰竭、肥大、缺血再灌注损伤和心肌缺血再灌注损伤。
• Use of pyridoxal phosphate derivatives for the treatment of diabetes and related complications
  申请人：Medicure Inc.

  公开号：EP1897547A1

  公开（公告）日：2008-03-12

  Use of a 3-acylated pyridoxal analogue, a pharmaceutically acceptable acid addition salt thereof, or a mixture thereof for the preparation of a medicament for treating insulin-dependent or non-insulin-dependent diabetes mellitus, related conditions, symptoms of insulin-dependent or non-insulin-dependent diabetes mellitus or related conditions, or any combination thereof in a mammal.

  3-酰化吡哆醛类似物、其药学上可接受的酸加成盐或其混合物用于制备治疗哺乳动物中胰岛素依赖型或非胰岛素依赖型糖尿病、相关病症、胰岛素依赖型或非胰岛素依赖型糖尿病或相关病症的症状或其任何组合的药物。
• Pyridoxal analogues and methods of treatment
  申请人：Medicure Inc.

  公开号：US20010031770A1

  公开（公告）日：2001-10-18

  Pyridoxal analogues can be useful for treating B 6 deficiency and related diseases; cardiovascular and related diseases; melanoma and related diseases; and symptoms thereof. One such analogue is a compound of the formula: 1 or a pharmaceutically acceptable acid addition salt thereof, in which R 1 is alkyl, alkenyl, in which alkyl or alkenyl can be interrupted by nitrogen, oxygen, or sulfur, and can be substituted at the terminal carbon by hydroxy, alkoxy, alkanoyloxy, alkanoyloxyaryl, alkoxyalkanoyl, alkoxycarbonyl, or dialkylcarbamoyloxy; alkoxy; dialkylamino; alkanoyloxy; alkanoyloxyaryl; alkoxyalkanoyl; alkoxycarbonyl; dialkylcarbamoyloxy; or aryl, aryloxy, arylthio, or aralkyl, in which aryl can be substituted by alky, alkoxy, amino, hydroxy, halo, nito, or alkanoyloxy. These analogues can be administered, either alone or concurrently with known medications, to treat the above-described diseases.

  吡哆醛类似物可用于治疗 B 6 缺乏症和相关疾病、心血管疾病和相关疾病、黑色素瘤和相关疾病及其症状。其中一种类似物是式中的化合物： 1 或其药学上可接受的酸加成盐，其中 R 1 是烷基、烯基，其中烷基或烯基可被氮、氧或硫打断，并可在末端碳被羟基、烷氧基、烷酰氧基、烷酰氧基芳基、烷氧基烷酰基、烷氧基羰基或二烷基氨基甲酰氧基取代；烷氧基；二烷基氨基；烷酰氧基；烷酰氧基芳基；烷氧基烷酰基；烷氧基羰基；二烷基氨基甲酰氧基；或芳基、芳氧基、芳硫基或芳烷基，其中芳基可被烷基、烷氧基、氨基、羟基、卤代、硝基或烷酰氧基取代。这些类似物可单独使用或与已知药物同时使用，以治疗上述疾病。