4-hydroxy-2-p-(methoxyphenyl)-6H-1,3-thiazin-6-one | 95642-52-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 4-hydroxy-2-p-(methoxyphenyl)-6H-1,3-thiazin-6-one
• 英文别名: 2-(4-methoxyphenyl)-4-hydroxy-6H-1,3-thiazin-6-one；2-(4-methoxyphenyl)-4-hydroxy-6-1,3-thiazine-6-one；4-hydroxy-2-(4-methoxyphenyl)-6H-1,3-thiazin-6-one；1,3-Thiazine-6-one-4-ol, 2-(4-methoxyphenyl)-；4-hydroxy-2-(4-methoxyphenyl)-1,3-thiazin-6-one
• CAS: 95642-52-7
• 化学式: C₁₁H₉NO₃S
• 分子量: 235.263
• InChiKey: XOOKNPBVNUIZJJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  84.2
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  4-hydroxy-2-p-(methoxyphenyl)-6H-1,3-thiazin-6-one 、 三氯氧磷 以21%的产率得到
  参考文献：
  名称：

  MIRONOVA, G. A.;KIRILLOVA, E. N.;KUKLIN, V. N.;SMORYGO, N. A.;IVIN, B. A., XIMIYA GETEROTSIKL. SOEDIN., 1984, N 10, 1328-1334

  摘要：

  DOI：
• 作为产物：
  描述：

  4-甲氧基硫代苯甲胺 、 二氧化三碳 以 乙酸乙酯 为溶剂， 以85%的产率得到4-hydroxy-2-p-(methoxyphenyl)-6H-1,3-thiazin-6-one
  参考文献：
  名称：

  Kuklin; Yakovlev; Smorygo, Russian Journal of General Chemistry, 1996, vol. 66, # 6, p. 985 - 997

  摘要：

  DOI：

文献信息

• Synthesis of 2,5-Disubstituted Derivatives of Pyrano[2,3-<i>d</i>][1,3]thiazines via the Interaction of 2-Substituted 4-Hydroxy-6<i>H</i>-1,3-thiazine-6-ones with Aldehydes
  作者：Roman V. Shutov、Marina V. Sopova、Alexander V. Krylov、Andry N. Kaluzhskikh、Boris А. Ivin

  DOI：10.1002/jhet.2226

  日期：2015.11

  A new and efficient route for the synthesis of derivatives of the poorly investigated pyrano[2,3‐d][1,3]thiazine heterocyclic system is disclosed. These compounds were prepared via annulation of 2‐aryl‐4‐hydroxy‐6H‐1,3‐thiazine‐6‐ones with aliphatic and aromatic aldehydes in the presence of pyridine. The method is general and versatile, and the interaction is independent on the nature of the aldehyde

  公开了一种新的有效途径，用于合成研究较少的吡喃并[2,3- d ] [1,3]噻嗪杂环系统的衍生物。这些化合物是通过在吡啶存在下，将2-芳基-4-羟基-6 H -1,3-噻嗪-6-与脂肪族和芳香族醛环合制得的。该方法是通用且通用的，并且相互作用与醛的性质无关，唯一的例外是甲醛和水杨醛。
• Investigations in the series of heterocycles. 55. Synthesis and some reactions of 2-aryl-4-halo-6-oxo-1,3-thiazines
  作者：G. A. Mironova、E. N. Kirillova、V. N. Kuklin、N. A. Smorygo、B. A. Ivin

  DOI：10.1007/bf00503595

  日期：1984.10
• Azines and azoles: CXXIV. New synthesis of 2-oxochromene-3-carboxamides
  作者：R. V. Shutov、A. N. Kaluzhskikh、A. V. Moskvin、B. A. Ivin

  DOI：10.1134/s1070363206050252

  日期：2006.5

  2-Aryl-4-hydroxy-6H-1,3-thiazin-6-ones react with substituted 2-hydroxybenzaldehydes in polar solvents to give N-arylcarbothioyl-2-oxochromene-3-carboxamides in 60-70% yield.
• Reaction of 2-aryl-4-hydroxy-6H-1,3-thiazin-6-ones with aromatic aldehydes in alcohols
  作者：M. V. Sopova、L. E. Mikhailov、A. V. Krylov、B. A. Ivin

  DOI：10.1134/s1070363207010276

  日期：2007.1
• A study of the reactions of 2-aryl-4-hydroxy-6H-1,3-thiazin-6-ones with chromone-3-carboxaldehydes
  作者：Roman V. Shutov、Elizaveta V. Kuklina、Boris A. Ivin

  DOI：10.1016/j.tetlet.2010.11.023

  日期：2011.1

  Reaction of 3-formylchromones with 2-aryl-4-hydroxy-6H-1,3-thiazin-6-ones in the presence of pyridine leads to formation of a mixture of novel N-thioaroyl-5-hydroxy-2H,5H-pyrano[3,2-c]chromen-2-one-3-carboxamides and 2-aryl-5-(4'-oxochromen-3'-yl)-6,7-dihydro-4H,5H-pyrano[2,3-d][1,3]thiazine-4,7-diones. The yields of these compounds clearly depend on the nature of the substituent on the 3-formylchromone and on the reaction conditions. (C) 2010 Elsevier Ltd. All rights reserved.