2-(3-chlorophenoxymethyl)pyridin-3-carbonic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-(3-chlorophenoxymethyl)pyridin-3-carbonic acid
• 英文别名: 2-[(3-Chlorophenoxy)methyl]pyridine-3-carboxylic acid
• 化学式: C₁₃H₁₀ClNO₃
• 分子量: 263.68
• InChiKey: LPEICFZOOHCYSJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  59.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-(3-chlorophenoxymethyl)pyridin-3-carbonic acid 在 PPA 作用下， 生成 8-chloro-11H-10-oxa-1-aza-dibenzo[a,d]cyclohepten-5-one
  参考文献：
  名称：

  两性药物。3.3-[（（5，11-二氢[1]苯并氧杂吡啶[4，3-b]吡啶基-11-亚基]哌啶子基]哌啶子基]丙酸衍生物和相关化合物的合成和抗过敏活性。

  摘要：

  描述了设计减少进入中枢神经系统（CNS）的抗过敏剂的重要方法。一系列3-[（5,11-二氢[1]苯并氧杂吡啶[4,3-b]-吡啶-11-亚基]哌啶子基]丙酸衍生物（31-47）及相关化合物（48-54）为与相应的6H-dibenz [b，e] oxepin衍生物（3）相比，合成并评估了化合物的抗过敏活性和对化合物的渗透性。两性离子化和引入吡啶组分的结合导致抗过敏活性的增加和对CNS的渗透性大大降低，通过中央系统的抗组胺活性的选择性（B / A）[离体H1与小鼠脑膜结合的ID50值（B）]和周围系统的抗组胺活性[ED50值对组胺的抑制作用]诱导的小鼠血管通透性增加] 可以基于两性离子化和吡啶组分的引入引起的亲水性的增加来考虑这种令人惊奇的渗透到CNS中的减少。3- [4-（8-氟-5,11-二氢[1]苯并xepino [4,3-b]吡啶基-11亚基）哌啶子基]丙酸（33）在各种实验模型中均表

  DOI：

  10.1021/jm00003a013
• 作为产物：
  描述：

  氮杂苯酞 、 3-氯苯酚 在 sodium methylate 作用下， 以 甲醇 为溶剂， 反应 4.0h， 以92%的产率得到2-(3-chlorophenoxymethyl)pyridin-3-carbonic acid
  参考文献：
  名称：

  Aza-Analogue Dibenzepinone Scaffolds as p38 Mitogen-Activated Protein Kinase Inhibitors: Design, Synthesis, and Biological Data of Inhibitors with Improved Physicochemical Properties

  摘要：

  We recently described a promising novel class of p38 mitogen activated protein (MAP) kinase inhibitors with dibenzepinone-scaffolds. To optimize their physicochemical properties, characterized by calculated log P values and measured lipophilicity (chromatographic hydrophobicity index = CHI), we synthesized aza-analogue dibenzepinones. Here, we present the synthesis and biological data of compounds with the novel aza-dibenzepinone scaffolds. Although these aza-analogues revealed an improved aqueous solubility, introduction of nitrogen was not effective in the p38 MAPK enzyme assay.

  DOI：

  10.1021/jm801291f

文献信息

• Amphoteric Drugs. 3. Synthesis and Antiallergic Activity of 3-[(5,11-Dihydro[1]benzoxepino[4,3-b]pyridin-11-ylidene)piperidino]propionic Acid Derivatives and Related Compounds
  作者：Nobuhiko Iwasaki、Tetsuo Ohashi、Keiichi Musoh、Hiroyuki Nishino、Noriyuki Kado、Shingo Yasuda、Hideo Kato、Yasuo Ito

  DOI：10.1021/jm00003a013

  日期：1995.2

  penetration into the central nervous system (CNS) is described. A series of 3-[(5,11- dihydro[1]benzoxepino[4,3-b]-pyridin-11-ylidene)piperidino]propion ic acid derivatives (31-47) and related compounds (48-54) were synthesized and evaluated for antiallergic activity and penetration of a compound into the CNS in comparison with the corresponding 6H-dibenz[b,e]oxepin derivative (3). Combination of zwitterionization

  描述了设计减少进入中枢神经系统（CNS）的抗过敏剂的重要方法。一系列3-[（5,11-二氢[1]苯并氧杂吡啶[4,3-b]-吡啶-11-亚基]哌啶子基]丙酸衍生物（31-47）及相关化合物（48-54）为与相应的6H-dibenz [b，e] oxepin衍生物（3）相比，合成并评估了化合物的抗过敏活性和对化合物的渗透性。两性离子化和引入吡啶组分的结合导致抗过敏活性的增加和对CNS的渗透性大大降低，通过中央系统的抗组胺活性的选择性（B / A）[离体H1与小鼠脑膜结合的ID50值（B）]和周围系统的抗组胺活性[ED50值对组胺的抑制作用]诱导的小鼠血管通透性增加] 可以基于两性离子化和吡啶组分的引入引起的亲水性的增加来考虑这种令人惊奇的渗透到CNS中的减少。3- [4-（8-氟-5,11-二氢[1]苯并xepino [4,3-b]吡啶基-11亚基）哌啶子基]丙酸（33）在各种实验模型中均表
• Aza-Analogue Dibenzepinone Scaffolds as p38 Mitogen-Activated Protein Kinase Inhibitors: Design, Synthesis, and Biological Data of Inhibitors with Improved Physicochemical Properties
  作者：Solveigh C. Karcher、Stefan A. Laufer

  DOI：10.1021/jm801291f

  日期：2009.3.26

  We recently described a promising novel class of p38 mitogen activated protein (MAP) kinase inhibitors with dibenzepinone-scaffolds. To optimize their physicochemical properties, characterized by calculated log P values and measured lipophilicity (chromatographic hydrophobicity index = CHI), we synthesized aza-analogue dibenzepinones. Here, we present the synthesis and biological data of compounds with the novel aza-dibenzepinone scaffolds. Although these aza-analogues revealed an improved aqueous solubility, introduction of nitrogen was not effective in the p38 MAPK enzyme assay.