2-[羧甲基(3-羟丙基)氨基]乙酸 | 59881-64-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 2-[羧甲基(3-羟丙基)氨基]乙酸
• 英文名称: (3-hydroxy-propylimino)-di-acetic acid
• 英文别名: 3-(Bis-carboxymethyl-amino)-propan-1-ol；(3-Hydroxy-propylimino)-di-essigsaeure；3-HIMDA；di(carboxymethyl)-(3-hydroxypropyl)amine；2,2'-[(3-Hydroxypropyl)azanediyl]diacetic acid；2-[carboxymethyl(3-hydroxypropyl)amino]acetic acid
• CAS: 59881-64-0
• 化学式: C₇H₁₃NO₅
• 分子量: 191.184
• InChiKey: UGCNGMZSWGWEES-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.2
• 重原子数：
  13
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  98.1
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2-[羧甲基(3-羟丙基)氨基]乙酸 在 1,4-二氧六环 、 三乙胺 作用下， 生成 (3-methacryloyloxy-propylimino)-di-acetic acid dimethyl ester
  参考文献：
  名称：

  Polycarboxyl- and polycarbalkoxyl-containing polymerizable quaternary ammonium monomes and their polymers

  摘要：

  公开号：

  US02729622A1
• 作为产物：
  描述：

  氯乙酸 、 3-氨基-1-丙醇 在 sodium hydroxide 作用下， 生成 2-[羧甲基(3-羟丙基)氨基]乙酸
  参考文献：
  名称：

  Polycarboxyl- and polycarbalkoxyl-containing polymerizable quaternary ammonium monomes and their polymers

  摘要：

  公开号：

  US02729622A1

文献信息

• Iron chelate solutions
  申请人：AMINKEMI AB

  公开号：EP0617008A1

  公开（公告）日：1994-09-28

  A method for the preparation of an aqueous solution of iron polyprotic acid chelate complexes, comprising reacting a solution of a mixture of a first polyprotic acid or a salt thereof, said first acid being capable of chelating iron, and a second polyprotic acid or a salt thereof, said second acid being capable of chelating iron and being different from the first acid, with iron in the presence of an oxidizing agent, with the proviso that at least part of the carboxylic acid groups in the first and second acids is present in salt form and at least part of the carboxylic acid groups in the first and second acids is present in acid form. Preferably, the first and second polyprotic acids may be selected from ethylenediaminetetraacetic acid (EDTA), N-hydroxyethyl-ethylenediaminetriacetic acid (HEDTA), and diethylenetriaminepentaacetic acid (DTPA), and the iron is selected from Fe-powder, Fe(OH)₂ and FeCO₃. Part of the polyprotic acid groups in the first and second acids is present in the salt form, the salt being selected from ammonium and alkali metal ions, in particular K⁺, Na⁺ and mixtures thereof. The method makes it possible to obtain aqueous solutions containing high contents of iron, such as up to approximately 7% by weight of iron, for use as a plant nutrient, mainly in soil-free plant culturing.

  一种制备铁多羧酸螯合物水溶液的方法，包括在氧化剂存在下，将第一多羧酸或其盐的混合物溶液与铁反应，所述第一酸能够螯合铁，和第二多羧酸或其盐，所述第二酸能够螯合铁且与第一酸不同，反应，其中第一和第二酸中至少部分羧基以盐形式存在，且第一和第二酸中至少部分羧基以酸形式存在。首选，第一和第二多羧酸可选自乙二胺四乙酸（EDTA）、N-羟乙基-乙二胺三乙酸（HEDTA）和二乙烯三胺五乙酸（DTPA），铁可选自Fe-粉末、Fe(OH)₂和FeCO₃。第一和第二酸中的多羧酸基的部分以盐形式存在，所述盐选自铵和碱金属离子，特别是K⁺、Na⁺和它们的混合物。该方法可获得含有高铁含量的水溶液，如高达约7%的铁含量，用作植物营养剂，主要用于无土栽培。
• Design and synthesis of site directed maleimide bifunctional chelators for technetium and rhenium
  作者：Sangeeta Ray Banerjee、Paul Schaffer、John W. Babich、John F. Valliant、Jon Zubieta

  DOI：10.1039/b507096a

  日期：——

  coordination of the M(CO)(3)}(+) core (M = Tc, Re), and a thiol reactive maleimide group has been prepared conveniently and in high yield under Mitsunobu reaction conditions by the coupling of an appropriate alcohol derivative with maleimide. The rhenium complexes [Re(CO)(3)(Lx)]Br (x= 1-9) were prepared in good yields from the reactions of the ligands and (NEt(4))(2)[Re(CO)(3)Br(3)] in refluxing methanol

  一个新的异双功能连接子家族（L1-L9），其末端包含一个三齿供体集合，用于协调M（CO）（3）}（+）核（M = Tc，Re）和硫醇反应性马来酰亚胺通过将适当的醇衍生物与马来酰亚胺偶联，在Mitsunobu反应条件下方便且高收率地制备了该基团。the配合物[Re（CO）（3）（Lx）] Br（x = 1-9）由配体与（NEt（4））（2）[Re（CO）（ 3）Br（3）]在回流的甲醇中。通过（1）H和（13）C NMR，IR和ESI-MS表征配体及其Re配合物。通过X射线晶体学对配体L4和[Re（CO）（3）（L5）] Br进行了结构表征。配合物[Re（CO）（3）（Lx）] Br（x = 4-6）溶液的光激发引起室温下强烈且长时间的发光（荧光寿命约为16微米）。在室温下，在磷酸盐缓冲液（PBS，pH 7.4）中，配体及其Re配合物在顺丁烯二酰亚胺连接基上与肽和蛋白质的巯基基团平滑反应，
• Site directed maleimide bifunctional chelators for the M(CO)3+ core (M =99mTc, Re)
  作者：Sangeeta Ray Banerjee、John W. Babich、Jon Zubieta

  DOI：10.1039/b417588c

  日期：——

  A series of bifunctional chelates containing a tridentate donor set for complexation of the M(CO)3+ core and a maleimide group for site-specific coupling to peptides and proteins containing free thiol groups has been prepared and their Re(CO)3+ complexes and glutathione conjugates structurally characterized. The flexibility of design allows preparation of ligands suitable for both fluorescence imaging, radioimaging and radiotherapeutic studies of proteins and peptides as well as other biopolymers using site specific conjugation.

  我们制备了一系列双功能螯合物，其中包含用于络合 M(CO)3+ 核心的三叉供体组和用于与含有游离硫醇基团的肽和蛋白质进行特定位点偶联的马来酰亚胺基团，并对它们的 Re(CO)3+ 复合物和谷胱甘肽共轭物进行了结构表征。设计的灵活性使得配体的制备既适用于蛋白质和肽的荧光成像、放射成像和放射治疗研究，也适用于使用位点特异性偶联的其他生物聚合物。
• Organosilicon compound
  申请人：Chisso Corporation

  公开号：EP1686133A2

  公开（公告）日：2006-08-02

  Since the majority of conventional organic/inorganic composite materials are obtained by mechanical blending of a silsesquioxane and an organic polymer or other means, it was extremely difficult to control the structure of the composite as a molecular agglomerate. In order to solve such a problem, the invention is to provide a silicon compound represented by Formula (1). This novel silicon compound has a living radical polymerization initiating ability for addition polymerizable monomers of a wide range. In Formula (1), R1 is hydrogen, an alkyl, an aryl, or an arylalkyl; R2 is an alkyl, phenyl, or cyclohexyl; and A is a group having a polymerization initiating ability for addition polymerizable monomers.

  由于传统的有机/无机复合材料大多是通过硅倍半氧烷和有机聚合物的机械混合或其他方式获得的，因此要控制复合材料的分子团聚结构极为困难。为了解决这一问题，本发明提供了一种由式（1）表示的硅化合物。这种新型硅化合物对范围广泛的可加成聚合单体具有活自由基聚合引发能力。在式（1）中，R1 是氢、烷基、芳基或芳烷基；R2 是烷基、苯基或环己基；A 是对可加成聚合单体具有聚合引发能力的基团。
• Organosilicon compound
  申请人：Chisso Corporation

  公开号：EP1849788A1

  公开（公告）日：2007-10-31

  There is provided a silicon compound represented by Formula (1) : wherein A is a group represented by Formula, (2-1): wherein Z1 is an alkylene having 3 to 20 carbon atoms, and arbitrary -CH2- in this alkylene may be replaced by -O-; R3 is hydrogen, an alkyl having 1 to 20 carbon atoms, an aryl having 6 to 20 carbon atoms, or an arylalkyl having 7 to 20 carbon atoms; R4 is an alkyl having 1 to 20 carbon atoms, an aryl having 6 to 20 carbon atoms, or an arylalkyl having 7 to 20 carbon atoms; and X1 is a halogen, and a process for producing said silicon compound represented by Formula (1-1).

  提供了一种由式（1）表示的硅化合物： 其中 A 是由式（2-1）表示的基团： 其中 Z1 是具有 3 至 20 个碳原子的亚烷基，该亚烷基中任意的-CH2-可被-O-取代； R3 是氢、具有 1 至 20 个碳原子的烷基、具有 6 至 20 个碳原子的芳基或具有 7 至 20 个碳原子的芳烷基； R4 是具有 1 至 20 个碳原子的烷基、具有 6 至 20 个碳原子的芳基或具有 7 至 20 个碳原子的芳烷基； X1 是卤素，以及 生产式（1-1）所代表的硅化合物的工艺。