4-(4-氯苯基)磺酰基苯酚 | 7402-67-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4-(4-氯苯基)磺酰基苯酚
• 英文名称: 4-((4-chlorophenyl)sulfonyl)phenol
• 英文别名: 4-Chlor-4'-hydroxy-diphenylsulfon；4-(4-chloro-benzenesulfonyl)-phenol；4-(4-chlorophenyl)sulfonylphenol
• CAS: 7402-67-7
• 化学式: C₁₂H₉ClO₃S
• 分子量: 268.721
• InChiKey: LFASIQLVFCSCCU-UHFFFAOYSA-N

物化性质

• 熔点：
  147.5-149 °C
• 沸点：
  462.3±30.0 °C(Predicted)
• 密度：
  1.428±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  62.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-(4-氯苯基)磺酰基苯酚 、 1,2,3-三氯-5-硝基苯 在 potassium carbonate 作用下， 以 N-甲基乙酰胺 为溶剂， 生成 4-(4-[4-chlorophenylsulfonyl]phenoxy)-3,5-dichloronitrobenzene
  参考文献：
  名称：

  Pesticidal phenoxypyridyl benzoyl ureas

  摘要：

  提供了新型苯氧苯基和苯氧吡啶基苯甲酰脲类化合物及其制备方法。这些新型脲类化合物可作为杀虫剂组合物中的活性毒剂。

  公开号：

  US04540578A1
• 作为产物：
  描述：

  4,4'-二氯二苯砜 以90%的产率得到
  参考文献：
  名称：

  Yang Bai, Zhang Tianyuan, Shen Jiacong, Yingyong huaxue (Chin. J. Appl. Chem), 11 (1994) N 1, S 88- 91

  摘要：

  DOI：

文献信息

• Compounds and uses thereof for decreasing activity of hormone-sensitive lipase
  申请人：——

  公开号：US20030166644A1

  公开（公告）日：2003-09-04

  Use of compounds to inhibit hormone-sensitive lipase, pharmaceutical compositions comprising the compounds, methods of treatment employing these compounds and compositions, and novel compounds. The present compounds are inhibitors of hormone-sensitive lipase and may be useful in the treatment and/or prevention of medical disorders where a decreased activity of hormone-sensitive lipase is desirable.

  使用化合物抑制激素敏感性脂肪酶，包括这些化合物的药物组合物，使用这些化合物和组合物的治疗方法，以及新化合物。目前的化合物是激素敏感性脂肪酶的抑制剂，可能在治疗和/或预防需要降低激素敏感性脂肪酶活性的医学疾病中有用。
• [EN] NEW CYCLOADDUCT PRECURSORS OF DIHALODIPHENYLSULFONES AND PREPARATIONS THEREOF<br/>[FR] NOUVEAUX PRÉCURSEURS DE CYCLOADDITION DE DIHALOGÉNODIPHÉNYLSULFONES ET LEURS PRÉPARATIONS
  申请人：RHODIA OPERATIONS

  公开号：WO2019030184A1

  公开（公告）日：2019-02-14

  The invention relates to new compounds of formula (I) wherein X represents a halogen atom selected from the group consisting of fluorine, chlorine, bromine and iodine, which are useful for the preparation of 4,4'dihalodiphenylsulfones of formula (III) wherein X is as defined above.

  这项发明涉及公式（I）中的新化合物，其中X代表从氟、氯、溴和碘组成的卤素原子，这些化合物可用于制备公式（III）中的4,4'-二卤二苯砜，其中X如上定义。
• Aminoheterocyclic derivatives as antithrombotic or anticoagulant agents
  申请人：ZENECA LIMITED

  公开号：US20030207882A1

  公开（公告）日：2003-11-06

  Compounds of formula (I), wherein G 1 is CH or N; G 2 is CH or N; R 1 is a variety of optional substituents, L 1 is (1-4C)alkylene; T 1 is CH or N; R 2 and R 3 are independently hydrogen or (1-4C)alkyl or are joined to form a ring; X 1 and X 2 represent various linking groups; Ar is phenylene or certain heteroaryl rings and Q represents a variety of aromatic or heterocyclic rings systems, and pharmaceutically acceptable salts thereof are described as useful antithrombotic and anticoagulant agents, and are selective Factor Xa inhibitors. Processes for their preparation and pharmaceutical compositions containing them are also described. 1

  式（I）的化合物，其中G1为CH或N；G2为CH或N；R1为各种可选取代基，L1为（1-4C）烷基；T1为CH或N；R2和R3独立地为氢或（1-4C）烷基或连接成环；X1和X2代表各种连接基团；Ar为苯基或特定杂环芳基，Q代表各种芳香或杂环芳基系统，及其药学上可接受的盐被描述为有用的抗血栓和抗凝血剂，并且是选择性的凝血因子Xa抑制剂。还描述了其制备方法和含有它们的药物组合物。
• AROMATIC SULFONIC ACID DERIVATIVE, SULFONIC ACID GROUP-CONTAINING POLYMER, BLOCK CO-POLYMER, POLYMER ELECTROLYTE MATERIAL, POLYMER ELECTROLYTE MOLDED BODY, AND SOLID POLYMER FUEL CELL
  申请人：Izuhara Daisuke

  公开号：US20140213671A1

  公开（公告）日：2014-07-31

  Provided are an aromatic sulfonic acid derivative and a sulfonic acid group-containing polymer, each of which has excellent proton conductivity even under low humidification conditions, while having excellent mechanical strength and chemical stability, and enables a solid polymer fuel cell to achieve high output and excellent physical durability when used therein. This aromatic sulfonic acid derivative has a specific structure and is characterized in that a sulfonic acid group is introduced into more than 50% of all the phenyl groups. This sulfonic acid group-containing polymer is characterized by being obtained by polymerization using the aromatic sulfonic acid derivative, and is also characterized by having a specific structure.

  提供了一种芳香磺酸衍生物和含有磺酸基团的聚合物，它们在低湿化条件下具有优异的质子导电性，同时具有优异的机械强度和化学稳定性，可使固体聚合物燃料电池在其中使用时实现高输出和优异的物理耐久性。这种芳香磺酸衍生物具有特定结构，其特点是将磺酸基团引入到超过50%的苯基中。这种含有磺酸基团的聚合物的特点是通过使用芳香磺酸衍生物进行聚合得到，并且具有特定的结构。
• A supramolecular carpet formed via self-assembly of bis(4,4′-dihydroxyphenyl) sulfone
  作者：Caitlin Davies、Richard F. Langler、C. V. Krishnamohan Sharma、Michael J. Zaworotko

  DOI：10.1039/a700363c

  日期：——

  Bis(4,4′-dihydroxyphenyl) sulfone 1 exploits its tetrahedrally disposed complementary hydrogen bonding sites to generate a unique doubly interwoven molecular carpet architecture in the solid state.

  双（4,4â²-二羟基苯基）砜 1 利用其四面体布置的互补氢键位点，在固态下生成了独特的双交织分子毯结构。