1,4-双-(4-氯苯氧基)苯 | 4333-15-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 1,4-双-(4-氯苯氧基)苯
• 英文名称: 1,4-bis-(4-chlorophenoxy)benzene
• 英文别名: 1,4-Bis-(4-chlor-phenoxy)-benzol；p-Di-(4-chlorphenoxy)-benzol；1,4-Bis(4-chlorophenoxy)benzene
• CAS: 4333-15-7
• 化学式: C₁₈H₁₂Cl₂O₂
• 分子量: 331.198
• InChiKey: CDKWVMNRYRQMQW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  [μ-[η6:η6-1,4-bis(4-chlorophenoxy)benzene]]bis(η5-cyclopentadienyl)diiron(II) bis(hexafluorophosphate) 以 二氯甲烷 、 乙腈 为溶剂， 以76%的产率得到1,4-双-(4-氯苯氧基)苯
  参考文献：
  名称：

  双（环戊二烯基铁）芳烃配合物：合成和官能化聚芳醚的新途径

  摘要：

  A new development in the chemistry of arenes activated toward S(N)Ar reactions by the cyclopentadienyliron (FeCp+) moiety is presented in this work. A class of diiron complexes of diphenoxybenzenes was prepared in a highly efficient and very mild fashion. Dihydroxyaromatic compounds served as dinucleophiles, allowing for the formation of the diiron complexes. This could be achieved in either a one or two step procedure. A wide variety of dinucleophiles were incorporated into this study, as well as a number of FeCp+ activated arenes. It is shown that these reactions are not inhibited by bulky substituents on either the dinucleophiles or activated arenes. The diiron complexes themselves could also undergo S(N)Ar reactions, provided that the complexed arenes contained a chlorine substituent. This allowed for the functionalization of the complexes with species that could not be introduced directly in their syntheses. The carbon nucleophiles generated from ethyl cyanoacetate or (phenylsulfonyl)acetonitrile could be attached to the complexed ethers in this manner. The FeCp+ moieties were removed easily by photolytic demetalation which allowed for the recovery of a wide range of functionalized diphenoxybenzenes. This methodology is advantageous over all those previously reported and should be a practical route to the synthesis of aromatic ethers.

  DOI：

  10.1021/om00013a055

文献信息

• Ligand-free highly effective iron/copper co-catalyzed formation of dimeric aryl ethers or sulfides
  作者：Xiaoming Qu、Tingyi Li、Yan Zhu、Peng Sun、Hailong Yang、Jincheng Mao

  DOI：10.1039/c1ob05155e

  日期：——

  Highly selective coupling of diiodoarenes with phenols or phenthiols can be performed by using a low-cost, benign character and readily available Fe/Cu catalytic system in the absence of ligands. It is noteworthy that the desired dimeric aryl ethers or sulfides could be obtained in high yields by coupling between diiodoarenes and phenols, or diphenols with aryl iodides.

  可以使用一种低成本、温和且易得的Fe/Cu催化体系，在无配体的条件下，选择性地将二碘芳烃与酚类或硫酚进行偶联。值得注意的是，通过二碘芳烃与酚类或二酚与芳基碘化物之间的偶联，能够以高产率获得所需的二聚芳醚或硫化物。
• Anisotropic melt polyesters with improved glass transition temperature
  申请人：E.I. DU PONT DE NEMOURS AND COMPANY

  公开号：EP0262900A2

  公开（公告）日：1988-04-06

  Novel melt-spinnable anisotropic-melt-forming polyesters from certain disubstituted hydroquinones and terephthalic acid have high glass transition temperatures.

  由某些二取代对苯二酚和对苯二甲酸制成的新型可熔融纺丝各向异性熔体成型聚酯具有很高的玻璃化转变温度。
• Cross-linkable thermotropic liquid crystalline aromatic polyesters
  申请人：HIMONT ITALIA S.r.l.

  公开号：EP0383177A2

  公开（公告）日：1990-08-22

  Cross-linkable thermotropic liquid crystalline aromatic polyesters comprising at least one unit derived from an aromatic diol substituted with at least one allyl group, in combination with units derived from dioxyaryl and dicarboxyaryl monomers.

  可交联热致伸缩液晶芳香族聚酯，包含至少一个由至少一个烯丙基取代的芳香族二元醇衍生的单元，以及由二羟基芳香族和二羧基芳香族单体衍生的单元。
• Selective displacement of aryl fluorides with hydroquinone: synthesis of 4-phenoxyphenols
  作者：Benjamin F. Marcune、Michael C. Hillier、Jean-François Marcoux、Guy R. Humphrey

  DOI：10.1016/j.tetlet.2005.09.025

  日期：2005.11

  The selective displacement of a variety of aryl fluorides with hydroquinone has been achieved to give substituted 4-phenoxyphenols 3. In some cases the addition of 18-crown-6 resulted in a significant rate enhancement, and the reactions could be carried out at lower temperature. One of these derivatives, 3a (X = Cl) was converted to 2-propyl-4-(4-chlorophenoxy)phenol 2a, a precursor to the PPAR gamma receptor agonist 1. (c) 2005 Elsevier Ltd. All rights reserved.
• BINÄRE LEGIERUNGEN AUF BASIS VON POLYETHERAMIDEN UND CYCLOOLEFINPOLYMEREN
  申请人：HOECHST AKTIENGESELLSCHAFT

  公开号：EP0576487A1

  公开（公告）日：1994-01-05