2-methylbenzo[d]oxazole-6-sulfonyl chloride | 52206-51-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶唑类
• 英文名称: 2-methylbenzo[d]oxazole-6-sulfonyl chloride
• 英文别名: 2-methylbenzoxazole-6-sulfonyl chloride；2-Methyl-1,3-benzoxazole-6-sulfonyl chloride
• CAS: 52206-51-6
• 化学式: C₈H₆ClNO₃S
• mdl: MFCD19200560
• 分子量: 231.66
• InChiKey: NHBYTQPVOGBVBM-UHFFFAOYSA-N

物化性质

• 沸点：
  349.8±15.0 °C(Predicted)
• 密度：
  1.519±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.125
• 拓扑面积：
  68.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  哌啶 、 2-methylbenzo[d]oxazole-6-sulfonyl chloride 在 水 、 Brine 、 Sodium sulfate-III 作用下， 以 氯仿 、 N,N-二甲基甲酰胺 为溶剂， 反应 1.0h， 以to provide 2.76 g (76%) of Compound 9 as a sticky white solid的产率得到N-(2-methylbenzoxazole-6-sulfonyl)piperidine
  参考文献：
  名称：

  Dyes for the detection or quantification of desirable target molecules

  摘要：

  本发明提供了染料、反应性染料和标记试剂，可用于检测或定量所需的目标分子，例如蛋白质和核酸。提供了可在溶液中自由使用的染料，其中染料与目标分子的结合提供信号生成。还提供了包含反应性基团的染料，可用于将染料附着到将结合到所需目标分子的探针上。本发明的新型染料通过添加带电和极性基团进行了改性，以提供有益的特性。

  公开号：

  US07569695B2
• 作为产物：
  描述：

  2-甲基苯并唑 在 氯磺酸 作用下， 反应 16.0h， 生成 2-methylbenzo[d]oxazole-6-sulfonyl chloride
  参考文献：
  名称：

  [EN] COMPOUNDS AND METHODS FOR THE TREATMENT OF CYSTIC FIBROSIS
  [FR] COMPOSÉS ET PROCÉDÉS POUR LE TRAITEMENT DE FIBROSE KYSTIQUE

  摘要：

  本发明涉及一种式I的化合物以及治疗囊性纤维化的方法，包括向需要的患者施用式I或IA化合物的治疗有效量的步骤。

  公开号：

  WO2014160478A1

文献信息

• Indole Compounds, Method of Preparing Them and Uses Thereof
  申请人：BINET Jean

  公开号：US20080153816A1

  公开（公告）日：2008-06-26

  Indole compounds corresponding to the formula (I): as defined in the claims, pharmaceutically acceptable addition salts of such compounds, pharmaceutical compositions containing such compounds, the process for their preparation, and their use as pharmacologically active substances, especially in the treatment of hypertriglyceridemia, hyperlipidemia, hypercholesterolemia, diabetes, endothelial dysfunction, cardiovascular disease, inflammatory disease and neurodegeneration.

  与公式（I）相对应的吲哚化合物，如权利要求中所定义的，这些化合物的药学上可接受的加盐物，含有这些化合物的药物组合物，其制备方法，以及它们作为药理活性物质的用途，特别是在治疗高三酰甘油血症、高脂血症、高胆固醇血症、糖尿病、内皮功能障碍、心血管疾病、炎症性疾病和神经退行性疾病方面。
• Novel dyes for the detection or quantification of desirable target molecules
  申请人：Xiang Yuejun

  公开号：US20060269926A1

  公开（公告）日：2006-11-30

  The present invention provides dyes, reactive dyes and labeled reagents that may be used in the detection or quantification of desirable target molecules, such as proteins and nucleic acids. Dyes are provided that may be used free in solution where the binding of the dye to the target molecule provides signal generation. Dyes are also provided that comprise reactive groups that may be used to attach the dyes to probes that will bind to desirable target molecules. The novel dyes of the present invention have been modified by the addition of charged and polar groups to provide beneficial properties.

  本发明提供了染料、活性染料和标记试剂，可用于检测或定量理想的靶分子，如蛋白质和核酸。提供了可在溶液中自由使用的染料，其中染料与靶分子的结合提供信号生成。还提供了包含活性基团的染料，可用于将染料附着到将结合到理想的靶分子的探针上。本发明的新型染料已通过添加带电和极性基团进行改性，以提供有益的特性。
• Methods for detecting the presence, location or quantity of targets using novel dyes
  申请人：Xiang Yuejun

  公开号：US20100041020A1

  公开（公告）日：2010-02-18

  The present invention provides dyes, reactive dyes and labeled reagents that may be used in the detection or quantification of desirable target molecules, such as proteins and nucleic acids. Dyes are provided that may be used free in solution where the binding of the dye to the target molecule provides signal generation. Dyes are also provided that comprise reactive groups that may be used to attach the dyes to probes that will bind to desirable target molecules. The novel dyes of the present invention have been modified by the addition of charged and polar groups to provide beneficial properties.

  本发明提供了染料、反应性染料和标记试剂，可用于检测或定量所需的目标分子，例如蛋白质和核酸。提供了可在溶液中自由使用的染料，其中染料与目标分子的结合提供信号生成。还提供了包含反应性基团的染料，可用于将染料连接到将结合到所需目标分子的探针上。本发明的新型染料已通过添加带电和极性基团进行改性，以提供有益的性质。
• Compositions useful for detection or quantification of desirable target molecules, novel dyes, composite dyes, and oligonucleotides or polynucleotides comprising such dyes
  申请人：Xiang Yuejun

  公开号：US20120040430A1

  公开（公告）日：2012-02-16

  The present invention provides dyes, reactive dyes and labeled reagents that may be used in the detection or quantification of desirable target molecules, such as proteins and nucleic acids. Dyes are provided that may be used free in solution where the binding of the dye to the target molecule provides signal generation. Dyes are also provided that comprise reactive groups that may be used to attach the dyes to probes that will bind to desirable target molecules. The novel dyes of the present invention have been modified by the addition of charged and polar groups to provide beneficial properties.

  本发明提供了染料、反应性染料和标记试剂，可用于检测或定量所需的目标分子，例如蛋白质和核酸。提供了可在溶液中自由使用的染料，其中染料与目标分子的结合提供信号生成。还提供了包含反应性基团的染料，可用于将染料附着到将结合到所需目标分子的探针上。本发明的新型染料已通过添加带电和极性基团进行改性，以提供有益的性质。
• Dyes linked to target molecules, oligonucleotides or polynucleotides comprising dye molecules, composite dyes and other compositions useful for detecting or quantifying desirable target molecules
  申请人：Enzo Life Sciences, Inc.

  公开号：US08153802B2

  公开（公告）日：2012-04-10

  The present invention provides dyes, reactive dyes and labeled reagents that may be used in the detection or quantification of desirable target molecules, such as proteins and nucleic acids. Dyes are provided that may be used free in solution where the binding of the dye to the target molecule provides signal generation. Dyes are also provided that comprise reactive groups that may be used to attach the dyes to probes that will bind to desirable target molecules. The novel dyes of the present invention have been modified by the addition of charged and polar groups to provide beneficial properties.

  本发明提供了染料、反应染料和标记试剂，可用于检测或定量所需的目标分子，如蛋白质和核酸。提供了可在溶液中自由使用的染料，其中染料与目标分子的结合提供信号产生。还提供了包含反应基团的染料，可用于将染料附着到将结合到所需目标分子的探针上。本发明的新型染料通过添加带电和极性基团进行了改性，以提供有益的性质。