2-[2-(4-chlorophenyl)ethenyl]benzaldehyde

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 2-[2-(4-chlorophenyl)ethenyl]benzaldehyde
• 英文别名: 2-[2-(4-Chlorophenyl)ethenyl]benzaldehyde
• 化学式: C₁₅H₁₁ClO
• 分子量: 242.705
• InChiKey: GPFHWLNJYWSQDJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-[2-(4-chlorophenyl)ethenyl]benzaldehyde 在 碘 作用下， 以 四氢呋喃 、 正庚烷 为溶剂， 反应 23.0h， 生成 4-(4-chlorophenyl)-2,3-dihydro-2-methyl-1H-2-benzazepine
  参考文献：
  名称：

  An investigation of the scope of the 1,7-electrocyclization of α,β:γ,δ-conjugated azomethine ylides

  摘要：

  Substituents on the diene component have little influence on the periselectivity of the cyclizations of alpha,beta:gamma,delta-conjugated azomethine ylides, with 1,7-electrocyclizations predominating. In some cases, subtle changes to these substituents can, however, influence the product formed, through their effect on the relative energies of the transition states for the 1,5- (6 pi) and 1,7-electrocyclization (8 pi) processes. The most striking changes in periselectivity occur for phenylethenyl-substituted azomethine ylides 3d-f, which can give either a pyrroline 4d,f or dihydrobenzazepine 6e, depending upon the alkene configuration. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2014.03.078
• 作为产物：
  描述：

  (4-chlorobenzyl)triphenylphosphonium bromide 在 sodium ethanolate 、 对甲苯磺酸 作用下， 以 乙醇 、 丙酮 为溶剂， 生成 2-[2-(4-chlorophenyl)ethenyl]benzaldehyde
  参考文献：
  名称：

  An investigation of the scope of the 1,7-electrocyclization of α,β:γ,δ-conjugated azomethine ylides

  摘要：

  Substituents on the diene component have little influence on the periselectivity of the cyclizations of alpha,beta:gamma,delta-conjugated azomethine ylides, with 1,7-electrocyclizations predominating. In some cases, subtle changes to these substituents can, however, influence the product formed, through their effect on the relative energies of the transition states for the 1,5- (6 pi) and 1,7-electrocyclization (8 pi) processes. The most striking changes in periselectivity occur for phenylethenyl-substituted azomethine ylides 3d-f, which can give either a pyrroline 4d,f or dihydrobenzazepine 6e, depending upon the alkene configuration. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2014.03.078

文献信息

• Cobalt‐Catalyzed Chemoselective Transfer Hydrogenation of C=C and C=O Bonds with Alkanols
  作者：Biao‐Lin Jiang、Shuang‐Shuang Ma、Meng‐Liang Wang、Dian‐Sheng Liu、Bao‐Hua Xu、Suo‐Jiang Zhang

  DOI：10.1002/cctc.201900010

  日期：2019.3.20

  this study, wherein the cobalt‐ bidentate phosphine catalyst precursor is commercially available and the active low‐valent Co species could be generated in‐situ. For the conjugation enones, the vinyl group is selectively reduced, whereas with nonconjugated alkenones, the selectivity is changed to the carbonyl group. Besides, ortho‐alkenyl‐benzaldehydes/imines are well tolerated, and the reduction solely

  这项研究开发了一种环境友好的方案，在无碱条件下用链烷醇对C = C和C = O键进行化学选择性转移加氢，其中钴二齿膦膦催化剂前体是可商购的，而活性低价Co物种可以原位生成。对于共轭烯酮，乙烯基被选择性地还原，而对于非共轭烯酮，选择性被改变为羰基。此外，邻链烯基苯甲醛/亚胺具有很好的耐受性，并且该方案仅在C = O / C = N位发生还原。
• SMALL MOLECULE HEMATOPOIETIC GROWTH FACTOR MIMETIC COMPOUNDS THAT ACTIVATE HEMATOPOIETIC GROWTH FACTOR RECEPTORS
  申请人：Zhi Lin

  公开号：US20110003851A1

  公开（公告）日：2011-01-06

  The present embodiments relate to compounds with physiological effects, such as the activation of hematopoietic growth factor receptors. The present embodiments also relate to use of the compounds to treat a variety of conditions, diseases and ailments such as hematopoietic conditions and disorders.

  本实施例涉及具有生理作用的化合物，例如激活造血生长因子受体。本实施例还涉及使用这些化合物来治疗各种情况、疾病和疾患，例如造血系统的疾病和疾患。
• <i>In Situ</i> Formed Acetal-Facilitated Synthesis of Substituted Indene Derivatives from <i>o</i>-Alkenylbenzaldehydes
  作者：Seetharaman Manojveer、Rengarajan Balamurugan

  DOI：10.1021/acs.orglett.5b01695

  日期：2015.7.17

  A new protocol has been developed for the synthesis of indene derivatives, in a diastereoselective manner from,o-alkenylbenzaldehydes and enolizable ketones hi the presence of trimethyl orthoformate and catalytic triflic acid. This method involves tandem in situ formed acetal-assisted Claisen-Schmidt condensation followed by 5-exo-trig cyclization/Michael addition in one-pot. It has also been shown that the chalcones derived from o-alkenylbenzaldehydes and ketones can effectively be transformed into indene derivatives in the presence of TfOH catalyst alone.
• Triphenylamine derivative, and charge transport material and electrophotographic photoreceptor using the same
  申请人：Takasago International Corporation

  公开号：EP2759530B1

  公开（公告）日：2015-09-23
• TRIPHENYLAMINE DERIVATIVE, AND CHARGE TRANSPORT MATERIAL AND ELECTROPHOTOGRAPHIC PHOTORECEPTOR USING THE SAME
  申请人：TAKASAGO INTERNATIONAL CORPORATION

  公开号：US20140213822A1

  公开（公告）日：2014-07-31

  Disclosed is a triphenylamine derivative represented by general formula (1): wherein R 1 , R 2 , R 3 , and R 5 each independently represent a hydrogen atom, a substituted or unsubstituted alkyl group, a substituted or unsubstituted alkoxy group, or a substituted or unsubstituted phenyl group, R 4 represents a hydrogen atom, a substituted or unsubstituted alkyl group, or a substituted or unsubstituted phenyl group, Ar represents a substituted or unsubstituted phenyl group, and m represents an integer of 1 to 3.