(4-Methoxy-phenyl)-[1-[5-(4-nitro-phenyl)-furan-2-yl]-meth-(E)-ylidene]-amine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (4-Methoxy-phenyl)-[1-[5-(4-nitro-phenyl)-furan-2-yl]-meth-(E)-ylidene]-amine
• 英文别名: N-(4-methoxyphenyl)-1-[5-(4-nitrophenyl)furan-2-yl]methanimine
• 化学式: C₁₈H₁₄N₂O₄
• 分子量: 322.32
• InChiKey: CJXGEDVGBKTMLK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  80.6
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-甲基苯并唑 、 (4-Methoxy-phenyl)-[1-[5-(4-nitro-phenyl)-furan-2-yl]-meth-(E)-ylidene]-amine 在 氢氧化钾 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 2-{(E)-2-[5-(4-Nitro-phenyl)-furan-2-yl]-vinyl}-benzooxazole
  参考文献：
  名称：

  5-Aryl-2-furaldehydes in the Synthesis of 2-Substituted 1,3-Benzazoles

  摘要：

  2-[2-(5-Aryl-2-furyl)ethenyl]-1,3-benzazoles were synthesized by reaction of 5-aryl-2-furaldehydes with 2-methylbenzoxazole, 2-methylbenzothiazole, 2-methylbenzimidazole, and 2-cyanomethylbenzimidazole. The corresponding benzazoles were also obtained by reaction of N-(5-arylfurfurylidene)anilines with 2-methylbenzoxazoles and of 3-(5-aryl-2-furyl)-2-cyanopropenoyl chlorides with o-phenylenediamine. The acylation of o-aminophenol with 3-(5-aryl-2-furyl)-2-cyanopropenoyI chlorides occurs at the amino group without subsequent oxazole ring closure.

  DOI：

  10.1023/b:rujo.0000010217.17000.e6
• 作为产物：
  描述：

  5-对硝基苯基糠醛 、 甲氧苯胺 在 sodium acetate 作用下， 以 乙醇 为溶剂， 反应 6.0h， 以87%的产率得到(4-Methoxy-phenyl)-[1-[5-(4-nitro-phenyl)-furan-2-yl]-meth-(E)-ylidene]-amine
  参考文献：
  名称：

  5-Aryl-2-furaldehydes in the Synthesis of 2-Substituted 1,3-Benzazoles

  摘要：

  2-[2-(5-Aryl-2-furyl)ethenyl]-1,3-benzazoles were synthesized by reaction of 5-aryl-2-furaldehydes with 2-methylbenzoxazole, 2-methylbenzothiazole, 2-methylbenzimidazole, and 2-cyanomethylbenzimidazole. The corresponding benzazoles were also obtained by reaction of N-(5-arylfurfurylidene)anilines with 2-methylbenzoxazoles and of 3-(5-aryl-2-furyl)-2-cyanopropenoyl chlorides with o-phenylenediamine. The acylation of o-aminophenol with 3-(5-aryl-2-furyl)-2-cyanopropenoyI chlorides occurs at the amino group without subsequent oxazole ring closure.

  DOI：

  10.1023/b:rujo.0000010217.17000.e6

文献信息

• 5-Aryl-2-furaldehydes in the Synthesis of 2-Substituted 1,3-Benzazoles
  作者：N. I. Ganushchak、A. I. Lesyuk、I. S. Fedorovich、N. D. Obushak、V. N. Andrushko

  DOI：10.1023/b:rujo.0000010217.17000.e6

  日期：2003.9

  2-[2-(5-Aryl-2-furyl)ethenyl]-1,3-benzazoles were synthesized by reaction of 5-aryl-2-furaldehydes with 2-methylbenzoxazole, 2-methylbenzothiazole, 2-methylbenzimidazole, and 2-cyanomethylbenzimidazole. The corresponding benzazoles were also obtained by reaction of N-(5-arylfurfurylidene)anilines with 2-methylbenzoxazoles and of 3-(5-aryl-2-furyl)-2-cyanopropenoyl chlorides with o-phenylenediamine. The acylation of o-aminophenol with 3-(5-aryl-2-furyl)-2-cyanopropenoyI chlorides occurs at the amino group without subsequent oxazole ring closure.