benzyl (3-methylbutan-2-yl)carbamate | 1444616-55-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: benzyl (3-methylbutan-2-yl)carbamate
• 英文别名: benzyl N-(3-methylbutan-2-yl)carbamate
• CAS: 1444616-55-0
• 化学式: C₁₃H₁₉NO₂
• mdl: MFCD32717018
• 分子量: 221.299
• InChiKey: SNOLOAVEJTZOPI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.461
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-甲基-2-丁烯 、 2-((((benzyloxy)carbonyl)amino)oxy)-2-methylpropanoic acid 在 [Ir(dF(CF₃)ppy)₂(dtbbpy)](PF₆) 、 水 、 sodium carbonate 、 苯硫酚 作用下， 以 二氯甲烷 为溶剂， 反应 16.0h， 以68%的产率得到benzyl (3-methylbutan-2-yl)carbamate
  参考文献：
  名称：

  未活化烯烃的反马尔科夫尼科夫自由基加氢和氘代酰胺化反应

  摘要：

  通过结合光氧化还原和硫醇催化，实现未活化烯烃的自由基抗马尔科夫尼科夫加氢和氘代氨基酰胺化反应。反应通过添加亲电子的CbzHN自由基（Cbz =羰基苄氧基）进行，该过程很容易通过α-Cbz-氨基氧基酸的单电子转移（SET）氧化反应生成烯烃。加成物自由基被作为有机极性反转助催化剂加入的苯硫酚还原，后者介导H从H 2 O转移至烷基自由基中间体。因此，通过使用D 2，以优异的D掺入实现了烯烃的氘代氨基酰胺化。O为化学计量形式的自由基还原剂。该反应具有低氧化还原催化剂负载量，出色的抗马尔可夫尼科夫选择性，并且不需要使用大量的过量烯烃。通过这种方法可以得到各种Cbz保护的伯胺，包括β氘代的胺。

  DOI：

  10.1002/chem.201901566

文献信息

• Stereoselective direct reductive amination of ketones with electron-deficient amines using Re2O7/NaPF6 catalyst
  作者：Braja Gopal Das、Prasanta Ghorai

  DOI：10.1039/c3ob40918j

  日期：——

  The first example of direct reductive amination (DRA) of ketones with electron-deficient amines (EDA) such as Cbz-, Boc-, EtOCO-, Fmoc-, Bz-, ArSO2-, etc. protected amines have been achieved using catalytic Re2O7/NaPF6. Excellent chemoselectivities as well as diastereoselectivity (for 2-alkyl cyclohexanones) were obtained.

  首次实现了使用催化剂Re2O7/NaPF6直接还原胺化（DRA）酮与电子贫乏的胺（EDA）如Cbz-、Boc-、EtOCO-、Fmoc-、Bz-、ArSO2-等保护的胺。获得了优异的化学选择性和对映选择性（对于2-烷基环己酮）。
• Indole derivatives and their metal conjugates and uses thereof
  申请人：Kulkarni Sudhir Appaji

  公开号：US20080242652A1

  公开（公告）日：2008-10-02

  Provided are compounds which are indole derivatives, as well as pharmaceutical compositions containing the compounds. Also provided are methods of using the indole compounds for preventing or treating a disease, or a condition that predisposes to a disease, wherein the disease or condition is associated with activation of the serine/threonine kinase B (Akt) in an animal. The method comprises administering to the animal a preventive or treatment effective amount of the indole compound. Further provided is a method for increasing apoptosis of an animal cell comprising contacting the cell with the indole compound.

  提供了一些吲哚衍生物化合物，以及含有这些化合物的药物组合物。同时还提供了使用这些吲哚化合物预防或治疗与动物体内丝氨酸/苏氨酸激酶B（Akt）活化相关的疾病或易感疾病的方法。该方法包括向动物体内投入预防或治疗有效量的吲哚化合物。此外，还提供了一种增加动物细胞凋亡的方法，包括将该化合物与细胞接触。
• INDOLE DERIVATIVES AND THEIR METAL CONJUGATES AND USES THEREOF
  申请人：Kulkarni Sudhir Appaji

  公开号：US20110021485A1

  公开（公告）日：2011-01-27

  Provided are compounds which are indole derivatives, as well as pharmaceutical compositions containing the compounds. Also provided are methods of using the indole compounds for preventing or treating a disease, or a condition that predisposes to a disease, wherein the disease or condition is associated with activation of the serine/threonine kinase B (Akt) in an animal. The method comprises administering to the animal a preventive or treatment effective amount of the indole compound. Further provided is a method for increasing apoptosis of an animal cell comprising contacting the cell with the indole compound.
• IAP BIR DOMAIN BINDING COMPOUNDS
  申请人：Laurent Alain

  公开号：US20130040892A1

  公开（公告）日：2013-02-14

  A compound of Formula 1: (I) or salt thereof, as well as methods of making compounds of Formula 1, methods of using compounds of Formula 1 to treat proliferative disorders such as cancer, and related compounds, composition, and methods.
• US7494988B2
  申请人：——

  公开号：US7494988B2

  公开（公告）日：2009-02-24