(R,S)-1-N-<(2,6-dimethyl)-phenoxyethyl>-amino-2-propanol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: (R,S)-1-N-<(2,6-dimethyl)-phenoxyethyl>-amino-2-propanol
• 英文别名: 1-[2-(2,6-Dimethylphenoxy)ethylamino]propan-2-ol
• 化学式: C₁₃H₂₁NO₂
• 分子量: 223.315
• InChiKey: UEEUZRZJBMTDHH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  41.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-(2,6-二甲基苯氧基)乙醇 在 吡啶 、 potassium carbonate 作用下， 反应 5.0h， 生成 (R,S)-1-N-<(2,6-dimethyl)-phenoxyethyl>-amino-2-propanol
  参考文献：
  名称：

  Marona, Henryk; Antkiewicz-Michaluk, Lucyna, Acta poloniae pharmaceutica, 1998, vol. 55, # 6, p. 487 - 498

  摘要：

  DOI：

文献信息

• DERIVATIVES OF AMINOALKANOLS, METHOD OF OBTAINING OF AMINOALKANOLS AND THEIR USE
  申请人：Marona Henryk

  公开号：US20110028562A1

  公开（公告）日：2011-02-03

  The subject of the invention is a group of new derivatives of aminoalkaπols, more specifically [(phenoxy)alkyl]aminoalkanols and [(phenoxy)acyl)aminoalkanols, their method of obtaining and their use for production of a medicine which is used in the prophylaxis, prevention and/or treatment of diseases or symptoms having neurological background and for production of a medicine with anticonvulsant activity, which is used in seizures of various origin, also in the limbic system, in myoclonic or sound-induced seizures, in psychomotor epilepsy, as well as in relieving neuropathic or inflammatory pain.

  本发明涉及一组新的氨基烷醇衍生物，更具体地是[(苯氧基)烷基]氨基烷醇和[(苯氧基)酰基)氨基烷醇，它们的获取方法以及它们用于生产用于预防、预防和/或治疗具有神经学背景的疾病或症状的药物，以及用于生产具有抗惊厥活性的药物，用于各种起源的癫痫发作，也用于边缘系统、肌阵挛或声音诱发的癫痫发作、精神运动性癫痫，以及缓解神经病性或炎症性疼痛。
• US8633251B2
  申请人：——

  公开号：US8633251B2

  公开（公告）日：2014-01-21
• US8841347B2
  申请人：——

  公开号：US8841347B2

  公开（公告）日：2014-09-23
• [EN] DERIVATIVES OF AMINOALKANOLS, METHOD OF OBTAINING OF AMINOALKANOLS AND THEIR USE<br/>[FR] DÉRIVÉS D'AMINOALCANOLS, PROCÉDÉ D'OBTENTION D'AMINOALCANOLS ET LEUR UTILISATION
  申请人：UNIV JAGIELLONSKI

  公开号：WO2009093916A2

  公开（公告）日：2009-07-30

  The subject of the invention is a group of new derivatives of aminoalkaπols, more specifically [(phenoxy)alkyl]aminoalkanols and [(phenoxy)acyl)aminoalkanols, their method of obtaining and their use for production of a medicine which is used in the prophylaxis, prevention and/or treatment of diseases or symptoms having neurological background and for production of a medicine with anticonvulsant activity, which is used in seizures of various origin, also in the limbic system, in myoclonic or sound-induced seizures, in psychomotor epilepsy, as well as in relieving neuropathic or inflammatory pain.
• Marona, Henryk; Antkiewicz-Michaluk, Lucyna, Acta poloniae pharmaceutica, 1998, vol. 55, # 6, p. 487 - 498
  作者：Marona, Henryk、Antkiewicz-Michaluk, Lucyna

  DOI：——

  日期：——