1-(2,4-二硝基苯基)-1-甲基肼 | 19255-35-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 1-(2,4-二硝基苯基)-1-甲基肼
• 英文名称: 1-methyl-1-(2,4-dinitrophenyl)hydrazine
• 英文别名: N-(2,4-dinitro-phenyl)-N-methyl-hydrazine；N-(2,4-Dinitro-phenyl)-N-methyl-hydrazin；1-(2,4-dinitrophenyl)-1-methyl-hydrazine；1-(2,4-dinitrophenyl)-1-methylhydrazine
• CAS: 19255-35-7
• 化学式: C₇H₈N₄O₄
• 分子量: 212.165
• InChiKey: YMBHFDADJOADTC-UHFFFAOYSA-N

物化性质

• 熔点：
  144 °C
• 沸点：
  393.4±32.0 °C(Predicted)
• 密度：
  1.534±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  121
• 氢给体数：
  1
• 氢受体数：
  6

安全信息

• 海关编码：
  2928000090

SDS

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Section 1. IDENTIFICATION OF THE SUBSTANCE/MIXTURE
Product identifiers
Product name : 1-(2,4-DINITROPHENYL)-1-METHYLHYDRAZINE
Relevant identified uses of the substance or mixture and uses advised against
Identified uses : Laboratory chemicals, Manufacture of substances

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Section 2. HAZARDS IDENTIFICATION
Classification of the substance or mixture
Classification according to Regulation (EC) No 1272/2008 [EU-GHS/CLP]
Skin sensitization (Category 1)
Classification according to EU Directives 67/548/EEC or 1999/45/EC
May cause sensitization by skin contact.
Label elements
Labelling according Regulation (EC) No 1272/2008 [CLP]
Pictogram
Signal word Warning
Hazard statement(s)
H317 May cause an allergic skin reaction.
Precautionary statement(s)
P280 Wear protective gloves.
Supplemental Hazard none
Statements
According to European Directive 67/548/EEC as amended.
Hazard symbol(s)
R-phrase(s)
R43 May cause sensitization by skin contact.
S-phrase(s)
S36/37 Wear suitable protective clothing and gloves.
Caution - substance not yet tested completely.
Other hazards - none

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Section 3. COMPOSITION/INFORMATION ON INGREDIENTS
Substances
Molecular Weight : 212,17 g/mol
Component Concentration
1-(2,4-DINITROPHENYL)-1-METHYLHYDRAZINE
CAS-No. 19255-35-7 -

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Section 4. FIRST AID MEASURES
Description of first aid measures
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
In case of skin contact
Wash off with soap and plenty of water. Consult a physician.
In case of eye contact
Flush eyes with water as a precaution.
If swallowed
Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
Most important symptoms and effects, both acute and delayed
To the best of our knowledge, the chemical, physical, and toxicological properties have not been
thoroughly investigated.
Indication of any immediate medical attention and special treatment needed
no data available

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Section 5. FIREFIGHTING MEASURES
Extinguishing media
Suitable extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, nitrogen oxides (NOx)
Advice for firefighters
Wear self contained breathing apparatus for fire fighting if necessary.
Further information
no data available

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Section 6. ACCIDENTAL RELEASE MEASURES
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure
adequate ventilation. Avoid breathing dust.
Environmental precautions
Do not let product enter drains.
Methods and materials for containment and cleaning up
Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed
containers for disposal.
Reference to other sections
For disposal see section 13.

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Section 7. HANDLING AND STORAGE
Precautions for safe handling
Avoid contact with skin and eyes. Avoid formation of dust and aerosols.
Provide appropriate exhaust ventilation at places where dust is formed.Normal measures for preventive fire
protection.
Conditions for safe storage, including any incompatibilities
Store in cool place. Keep container tightly closed in a dry and well-ventilated place.
Specific end uses
no data available

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Section 8. EXPOSURE CONTROLS/PERSONAL PROTECTION
Control parameters
Components with workplace control parameters
Exposure controls
Appropriate engineering controls
Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and
at the end of workday.
Personal protective equipment
Eye/face protection
Face shield and safety glasses Use equipment for eye protection tested and approved under
appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique
(without touching glove's outer surface) to avoid skin contact with this product. Dispose of
contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.
The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and
the standard EN 374 derived from it.
Body Protection
Complete suit protecting against chemicals, The type of protective equipment must be selected
according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection
For nuisance exposures use type P95 (US) or type P1 (EU EN 143) particle respirator.For higher
level protection use type OV/AG/P99 (US) or type ABEK-P2 (EU EN 143) respirator cartridges.
Use respirators and components tested and approved under appropriate government standards
such as NIOSH (US) or CEN (EU).

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Section 9. PHYSICAL AND CHEMICAL PROPERTIES
Information on basic physical and chemical properties
a) Appearance Form: solid
b) Odour no data available
c) Odour Threshold no data available
d) pH no data available
e) Melting point/freezing no data available
point
f) Initial boiling point and no data available
boiling range
g) Flash point not applicable
h) Evaporation rate no data available
i) Flammability (solid, gas) no data available
j) Upper/lower no data available
flammability or
explosive limits
k) Vapour pressure no data available
l) Vapour density no data available
m) Relative density no data available
n) Water solubility no data available
o) Partition coefficient: n- log Pow: -0,493
octanol/water
p) Autoignition no data available
temperature
q) Decomposition no data available
temperature
r) Viscosity no data available
s) Explosive properties no data available
t) Oxidizing properties no data available
Other safety information
no data available

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Section 10. STABILITY AND REACTIVITY
Reactivity
no data available
Chemical stability
no data available
Possibility of hazardous reactions
no data available
Conditions to avoid
no data available
Incompatible materials
Strong oxidizing agents
Hazardous decomposition products
Other decomposition products - no data available

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Section 11. TOXICOLOGICAL INFORMATION
Information on toxicological effects
Acute toxicity
no data available
Skin corrosion/irritation
no data available
Serious eye damage/eye irritation
no data available
Respiratory or skin sensitization
May cause sensitization by skin contact.
Germ cell mutagenicity
no data available
Carcinogenicity
IARC: No component of this product present at levels greater than or equal to 0.1% is identified as
probable, possible or confirmed human carcinogen by IARC.
Reproductive toxicity
no data available
Specific target organ toxicity - single exposure
no data available
Specific target organ toxicity - repeated exposure
no data available
Aspiration hazard
no data available
Potential health effects
Inhalation May be harmful if inhaled. May cause respiratory tract irritation.
Ingestion May be harmful if swallowed.
Skin
May be harmful if absorbed through skin. May cause skin irritation.
Eyes May cause eye irritation.
Signs and Symptoms of Exposure
To the best of our knowledge, the chemical, physical, and toxicological properties have not been
thoroughly investigated.
Additional Information
RTECS: Not available

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Section 12. ECOLOGICAL INFORMATION
Toxicity
no data available
Persistence and degradability
no data available
Bioaccumulative potential
no data available
Mobility in soil
no data available
Results of PBT and vPvB assessment
no data available
Other adverse effects
no data available

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Section 13. DISPOSAL CONSIDERATIONS
Waste treatment methods
Product
Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed
professional waste disposal service to dispose of this material. Dissolve or mix the material with a
combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber.
Contaminated packaging
Dispose of as unused product.

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Section 14. TRANSPORT INFORMATION
UN number
ADR/RID: - IMDG: - IATA: -
UN proper shipping name
ADR/RID: Not dangerous goods
IMDG: Not dangerous goods
IATA: Not dangerous goods
Transport hazard class(es)
ADR/RID: - IMDG: - IATA: -
Packaging group
ADR/RID: - IMDG: - IATA: -
Environmental hazards
ADR/RID: no IMDG Marine pollutant: no IATA: no
Special precautions for user
no data available

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SECTION 15 - REGULATORY INFORMATION
N/A

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  1-(2,4-二硝基苯基)-1-甲基肼 在 硫酸 、 二氧化氮 作用下， 以 水 为溶剂， 以76%的产率得到N-甲基-2,4-二硝基苯胺
  参考文献：
  名称：

  1-甲基-1-（2,4-二硝基苯基）肼用作HPLC测定醛的新试剂。

  摘要：

  描述了N-烷基化肼试剂的合成和首次应用，用于HPLC测定醛和酮。1-甲基-1-（2,4-二硝基苯基）肼（MDNPH）与醛反应，在酸作为催化剂的情况下生成相应的。与其他肼试剂相比，MDNPH被臭氧和二氧化氮定量氧化为N-甲基-2,4-二硝基苯胺（MDNA），可通过HPLC将其与低级醛的hydr分离。与2，4-二硝基苯基hydr相比，1-甲基-1-（2,4-二硝基苯基）hydr的洗脱顺序出乎意料。双波长检测被用作鉴定the和MDNA的不同基团的手段。

  DOI：

  10.1021/ac970146p
• 作为产物：
  描述：

  1-氯-2,4-二硝基苯 、 甲基肼 以 乙醇 为溶剂， 生成 1-(2,4-二硝基苯基)-1-甲基肼
  参考文献：
  名称：

  竞争性的酰基转移和分子内O→N酰基从可分离的O-酰基异脲中的迁移

  摘要：

  的Ô -acylisourea（16A），其为模型所提出的中间在碳化二亚胺缩合，和被形成在的酰氯（15）与苯甲酸根离子反应，使用显示出X射线晶体学有ž -构型。晶体是单斜晶，空间群P 2 1 / c，在一个单元中具有四个分子，其尺寸为a = 15.732（3），b = 16.246（5），c = 7.628（1）Å，β= 108.94（1）°。通过直接方法解析结构，并通过全矩阵最小二乘计算将1 281个所观察到的反射的R值改进为0.044。苯甲酰基是反式的亚胺氮的孤对上，C N键的长度为1.286（6）Å。异脲未经催化处理（在25°C下，在1：4二恶烷-水中，μ= 1.0）中O → N酰基转移，在pH> 7的情况下生成N-酰基酰胺（17）。缓慢的步骤是Z → E异构化。在较低的pH（3–6）下，异脲的Z → E异构化（因此发生O → N酰基转移）被酸催化，但在pH

  DOI：

  10.1039/p29800000867

文献信息

• Potential anticonvulsants. VIII. Some hydrazones of indole-3-carboxaldehyde
  作者：Frank D. Popp

  DOI：10.1002/jhet.5570210273

  日期：1984.3

  Indole-3-carboxaldehyde and some additional aldehydes were condensed with various hydrazines, hydrazides, and related compounds. A number of the products exhibited low levels of anticonvulsant activity.

  吲哚-3-羧醛和一些其他醛与各种肼，酰肼和相关化合物缩合。许多产品表现出低水平的抗惊厥活性。
• Potential anticonvulsants. IX. Some isatin hydrazones and related compounds
  作者：Frank D. Popp

  DOI：10.1002/jhet.5570210614

  日期：1984.11

  A number of hydrazines, hydrazides, and related compounds have been condensed with isatin and substituted isatins. The anticonvulsant activity of these compounds is reported.

  许多肼，酰肼和相关化合物已与Isatin和取代的Isatin缩合。报道了这些化合物的抗惊厥活性。
• Studies on the synthesis of indole alkaloids
  作者：Joan Bosch、Marisa Salas、Mercedes Amat、Mercedes Alvarez、Isabel Morgó、Bartomeu Adrover

  DOI：10.1016/s0040-4020(01)87138-6

  日期：1991.1

  substructure of Strychnos alkaloids and a Nb-(formylmethyl) substituent protected as an oxime or hydrazone derivative, have been prepared by nucleophilic addition of the enolate of indoleacetic ester 1 to pyridinium salts 2b–d followed by acid cyclization. The same one-pot, two-step sequence allowed the preparation of tetracycle 3f, which incorporates an α-methoxyacrylate chain at the piperidine β-position

  Tetracycles 3B-d ，具有的ABCD环子马钱子碱和一个Ñ b - （甲酰基甲基）取代基保护为肟或腙衍生物，制备通过亲核加成的吲哚酯的烯醇化物的1到吡啶鎓盐2B-d随后通过酸环化。相同的一锅两步程序允许制备四环3f，该四环3f在哌啶β位置掺入了α-甲氧基丙烯酸酯链。
• The preparation, spectroscopy, structure and electrochemistry of some [Co(η4-C4Ph4)(η5-C5H4CC–CHY)], [Fe(η5-C5H5)(η5-C5H4CC–CHY)], and related complexes
  作者：Donagh Courtney、C. John McAdam、Anthony R. Manning、Helge Müller-Bunz、Yannick Ortin、Jim Simpson

  DOI：10.1016/j.jorganchem.2011.12.012

  日期：2012.5

  2)2-2,4}], 7b. With [Fe2(η-C5H5)2(CO)2(μ-CO)(μ-CMe)][BF4] 4a and 4b form blue-green [Fe2(η-C5H5)2(CO)2(μ-CO)(μ-C–CHCH-CC–C5H4-η5)Co(η4-C4Ph4)][BF4], [8a][BF4], and black [Fe2(η-C5H5)2(CO)2(μ-CO)(μ-C–CHCH–CC–C5H4-η5)Fe(η5-C5H5)][BF4], [8b][BF4] salts. 4a and 4b also react with the Wittig reagent [Fe(η5-C5H5)(η5-C5H4–CH2PPh3)][I]/nBuLi to give mixtures of Z and E-[Co(η4-C4Ph4)(η5-C5H4–CC–CHCH–C5H4-η5)Fe(η5-C5H5)]

  [CO（η 4 -C 4博士4）（η 5 -C 5 H ^ 4 Ç C-CHO）]，4A，已从[CO（η制备4 -C 4博士4）（η 5 -C 5 H ^ 4 CHO）]，1A，通过类似于那些之前用于转换的[Fe（η反应5 -C 5 H ^ 5）（η 5 -C 5 H ^ 4 CHO）]，1B，到的[Fe（η 5 -C 5 ħ 5）（η 5-C 5 ħ 4 Ç Ç - CHO）]，4B，即，经由dibromoethene [CO（η 4 -C 4博士4）（η 5 -C 5 H ^ 4 CH CBR 2）]，图2a，和炔[CO（ η 4 -C 4博士4）（η 5 -C 5 H ^ 4 ç CH）]，3A。4a和4b均与丙二腈和2,4-二硝基苯肼进行正常的醛反应，得到各自的缩合产物[Co（η4 -C 4博士4）η 5 -C 5 H ^ 4 Ç Ç -C -CH C（CN）2 }]，5A，和的[Fe（η
• Reaction of 1,1-disubstituted hydrazines with bromine in the presence of aryl- and heteroarylnitroso compounds in acid media: A general method for the synthesis of 1-aryl(heteroaryl)-3,3-disubstituted triazene 1-oxides
  作者：S. G. Zlotin、O. V. Prokshits、N. F. Karpenko、Yu. A. Strelenko、O. A. Luk'yanov

  DOI：10.1007/bf00864338

  日期：1992.8

  We have worked out a method for the synthesis of 1,3,3-trisubstituted triazene 1-oxides based upon reaction of 1,1-disubstituted hydrazines with bromine in the presence of aryl- and heteroarylnitroso compounds in acid media. Obtained are a broad range of triazene 1-oxides, among which hitherto unknown compounds of the series of pyrazole and 3,3-dialkyltriazene 1-oxides that contain functional groups at the alkyl part of the molecule. We propose a reaction scheme which includes in situ formation of diazenium cations and reaction of them with nitroso compounds that are present in the system. By means of PMR, C-13, and N-14 NMR spectroscopy, and mass spectroscopy, it has been shown that in all the prepared compounds the oxidated nitrogen atom is at the N1 position of the triazene N-oxide group.

表征谱图