{Pt2} | 109995-68-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: {Pt2}
• CAS: 109995-68-8
• 化学式: C₁₀H₁₂Cl₂N₄Pt
• 分子量: 454.218
• InChiKey: HICCNTUBFNTCNK-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  3-氨基吡啶 、 potassium tetrachloroplatinate(II) 以 not given 为溶剂， 生成 {Pt2}
  参考文献：
  名称：

  Rosenheim, A.; Haendler, W., Chemische Berichte, 1926, vol. 59, p. 1387 - 1390

  摘要：

  DOI：

文献信息

• The synthesis, structure-toxicity relationship of cisplatin derivatives for the mechanism research of cisplatin-induced nephrotoxicity
  作者：Jing Hu、Tian-Ming Wu、Hong-Ze Li、Ze-Ping Zuo、Ying-Lan Zhao、Li Yang

  DOI：10.1016/j.bmcl.2017.04.077

  日期：2017.8

  Cisplatin is a widely used antineoplastic drug, while its nephrotoxicity limits the clinical application. Although several mechanisms contributing to nephrotoxicity have been reported, the direct protein targets are unclear. Herein we reported the synthesis of 29 cisplatin derivatives and the structure-toxicity relationship (STR) of these compounds with MTT assay in human renal proximal tubule cells (HK-2) and pig kidney epithelial cells (LLC-PK1). To the best of our knowledge, this study represented the first report regarding the structure-toxicity relationship (STR) of cisplatin derivatives. The potency of biotin-pyridine conjugated derivative 3 met the requirement for target identification, and the preliminary chemical proteomics results suggested that it is a promising tool for further target identification of cisplatin-induced nephrotoxicity. (C) 2017 Published by Elsevier Ltd.
• Gmelin Handbuch der Anorganischen Chemie, Gmelin Handbook: Pt: MVol.D, 128, page 288 - 290
  作者：

  DOI：——

  日期：——