2',3',5'-tri-O-benzoyl-3-methyl-5-(trifluoromethyl)uridine

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 英文名称: 2',3',5'-tri-O-benzoyl-3-methyl-5-(trifluoromethyl)uridine
• 英文别名: [(2R,3R,4R,5R)-3,4-dibenzoyloxy-5-[3-methyl-2,4-dioxo-5-(trifluoromethyl)pyrimidin-1-yl]oxolan-2-yl]methyl benzoate
• 化学式: C₃₂H₂₅F₃N₂O₉
• 分子量: 638.554
• InChiKey: ZOGHYFWSLKWLQJ-DLGLWYJGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  46
• 可旋转键数：
  11
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  129
• 氢给体数：
  0
• 氢受体数：
  12

反应信息

• 作为产物：
  描述：

  2',3',5'-tri-O-benzoyl-5-iodouridine 在 二[三氟甲基]汞 、 铜 、 potassium carbonate 作用下， 以 N,N-二甲基乙酰胺 、 N,N-二甲基甲酰胺 为溶剂， 反应 4.0h， 生成 2',3',5'-tri-O-benzoyl-3-methyl-5-(trifluoromethyl)uridine
  参考文献：
  名称：

  Trifluoromethylation of Alkenyl Bromides and Iodides (Including 5-Iodouracils) with (CF₃)₂Hgand Cu (“Trifluoromethylcopper”)¹

  摘要：

  [GRAPHIC]Bromo- and iodoalkenes undergo trifluoromethylation efficiently in DMA with "CF3Cu" generated from (CF3)(2)Hg and Cu. Variable stereochemical inversion is observed with substrates having a gem-carbonyl group. Substrates having gem-hydrogen, -alkyl, or -alkenyl groups give products with stereochemical retention.

  DOI：

  10.1021/jo062544a

文献信息

• Trifluoromethylation of Alkenyl Bromides and Iodides (Including 5-Iodouracils) with (CF₃)₂Hgand Cu (“Trifluoromethylcopper”)¹
  作者：Ireneusz Nowak、Morris J. Robins

  DOI：10.1021/jo062544a

  日期：2007.3.1

  [GRAPHIC]Bromo- and iodoalkenes undergo trifluoromethylation efficiently in DMA with "CF3Cu" generated from (CF3)(2)Hg and Cu. Variable stereochemical inversion is observed with substrates having a gem-carbonyl group. Substrates having gem-hydrogen, -alkyl, or -alkenyl groups give products with stereochemical retention.