5-(((4-fluorophenyl)thio)methyl)-2-phenyl-4,5-dihydrooxazole

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 5-(((4-fluorophenyl)thio)methyl)-2-phenyl-4,5-dihydrooxazole
• 英文别名: 5-[(4-Fluorophenyl)sulfanylmethyl]-2-phenyl-4,5-dihydro-1,3-oxazole；5-[(4-fluorophenyl)sulfanylmethyl]-2-phenyl-4,5-dihydro-1,3-oxazole
• 化学式: C₁₆H₁₄FNOS
• 分子量: 287.358
• InChiKey: DHEQGQYSPLEWRB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  46.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1-氟-4-[(4-氟苯基)二硫烷基]苯 在 三氟甲磺酸 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 生成 5-(((4-fluorophenyl)thio)methyl)-2-phenyl-4,5-dihydrooxazole
  参考文献：
  名称：

  Synthesis of Oxazolines from N-Allylamides Using an Electrochemically Generated ArS(ArSSAr)+ Pool

  摘要：

  The reaction of N-allylamides with ArS(ArSSAr)(+), which was generated and accumulated by the low-temperature anodic oxidation of ArSSAr, afforded the corresponding ArS-substituted oxazolines in moderate to good yields. In-situ electrochemical oxidation of ArSSAr in the presence of N-allylamides was also applicable. Oxazolines bearing various substituents were successfully synthesized by using the present reactions.

  DOI：

  10.3987/com-18-13942

文献信息

• Synthesis of Oxazolines from N-Allylamides Using an Electrochemically Generated ArS(ArSSAr)+ Pool
  作者：Kouichi Matsumoto、Jun-ichi Yoshida、Yu Miyamoto、Naoya Mitani、Rina Yanagi、Shigenori Kashimura、Seiji Suga

  DOI：10.3987/com-18-13942

  日期：——

  The reaction of N-allylamides with ArS(ArSSAr)(+), which was generated and accumulated by the low-temperature anodic oxidation of ArSSAr, afforded the corresponding ArS-substituted oxazolines in moderate to good yields. In-situ electrochemical oxidation of ArSSAr in the presence of N-allylamides was also applicable. Oxazolines bearing various substituents were successfully synthesized by using the present reactions.