trans-4-(aminomethyl)cyclohexane carboxylic acid hydrochloride

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: trans-4-(aminomethyl)cyclohexane carboxylic acid hydrochloride
• 英文别名: cis-4-aminomethyl cyclohexane-1-carboxylic acid hydrochloride；4-(Aminomethyl)cyclohexane-1-carboxylic acid;hydron;chloride；4-(aminomethyl)cyclohexane-1-carboxylic acid;hydron;chloride
• 化学式: C₈H₁₅NO₂*ClH
• 分子量: 193.674
• InChiKey: UGECKKSVDQIZQG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.26
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  63.3
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  trans-4-(aminomethyl)cyclohexane carboxylic acid hydrochloride 、 二碳酸二叔丁酯 以94%的产率得到
  参考文献：
  名称：

  SVAHN, C. M.;MERENYI, F.;KARLSON, L.;WIDLUND, L.;GRAELLS, M., J. MED. CHEM., 1986, 29, N 4, 448-453

  摘要：

  DOI：
• 作为产物：
  描述：

  tranexamic acid 在 盐酸 作用下， 以 水 为溶剂， 反应 4.0h， 生成 trans-4-(aminomethyl)cyclohexane carboxylic acid hydrochloride
  参考文献：
  名称：

  Immobilization of self-quenched DNA hairpin probe with a heterobifunctional reagent on a glass surface for sensitive detection of oligonucleotides

  摘要：

  A new sensitive method for the detection of nucleic acids on a glass surface has been described. The self-quenched DNA hairpin probe is immobilized on a glass surface utilizing heterobifunctional reagent, N-(3-triethoxysilylpropyl)-4-(isothiocyanatomethyl)-cyclohexane-1-carboxamide (TPICC). In the closed state fluorescence intensity was quenched due to the presence of guanosine residues in close vicinity of fluorophore while on hybridization with perfectly matched complementary target strand fluorescence was restored. Efficiency and specificity of immobilization as well as thermal stability at variable temperature and pH conditions have been discussed in detail. The method employed has potential for the detection of single nucleotide variations and other diagnostic studies. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2009.07.015

文献信息

• DERIVATIVES OF SUBSTITUTED TARTARIC ACID AND USAGE FOR PREPARING BETA-SECRETASE INHIBITORS
  申请人：Li Song

  公开号：US20100331345A1

  公开（公告）日：2010-12-30

  The present invention relates to compounds represented by formula (I), or isomers, prodrugs, pharmaceutically acceptable salts, solvates or hydrates thereof: in which each substituent of formula (I) is as defined in the specification. The present invention also relates to preparation methods of compounds represented by formula (I), a pharmaceutical composition comprising compounds represented by formula (I) and usage of compounds represented by formula (I) for treating chronic neurodegenerative diseases such as Alzheimer's disease and other diseases induced by aggregation or deposition of β-amyloid peptide.

  本发明涉及由式(I)表示的化合物，或其异构体、前药、药用可接受的盐、溶剂合物或水合物：其中式(I)的每个取代基如规范中所定义。本发明还涉及由式(I)表示的化合物的制备方法，包括由式(I)表示的化合物的药物组合物以及利用由式(I)表示的化合物治疗慢性神经退行性疾病，如阿尔茨海默病和其他由β-淀粉样蛋白聚集或沉积引起的疾病。
• [EN] GD COMPLEX COMPRISING DTPA-BIS-AMIDE LIGAND AND METHOD FOR PREPARING THE SAME<br/>[FR] COMPLEXE DE GD COMPORTANT UN LIGAND DTPA-BIS-AMIDE, ET SON PROCÉDÉ DE PRÉPARATION
  申请人：KYUNGPOOK NAT UNIV IND ACAD

  公开号：WO2009145378A1

  公开（公告）日：2009-12-03

  A method of preparing a new DTPA-bis-amide ligand includes the following: first step of adding DTPA-bis-anhydride to N,N-dimethylformamide to with stirring; second step of adding 2-hydroxyethyl-trans-4-(aminomethyl)cyclohexyl carboxylate hydrochloride, 2-methoxyethyl-trans-4-(aminomethyl) cyclohexyl carboxylate hydrochloride, or allyl-trans-4-(aminomethyl)cyclohexyl carboxylate hydrochloride with stirring; third step of conducting silica gel chromatography after removing all of solvent under low pressure and adding methanol to dissolve; and fourth step of drying the product under vacuum state. Further, a method of preparing a new Gadolinium complex further includes fifth step of putting the obtained DTPA-bis-amide ligand to the distilled water, and adding Gd2O3 with stirring; sixth step of removing impurity and solvent; and seventh step of dissolving it in methanol and precipitating it with acetonitrile to obtain a solid.

  一种制备新的DTPA-bis-amide配体的方法包括以下步骤：第一步将DTPA-bis-anhydride加入N，N-二甲基甲酰胺中并搅拌；第二步加入2-羟乙基-trans-4-(氨甲基)环己基羧酸盐酸盐、2-甲氧基乙基-trans-4-(氨甲基)环己基羧酸盐酸盐或烯丙基-trans-4-(氨甲基)环己基羧酸盐酸盐并搅拌；第三步在低压下去除所有溶剂并加入甲醇后进行硅胶层析；第四步在真空状态下干燥产物。此外，一种制备新的钆配合物的方法还包括第五步将得到的DTPA-bis-amide配体放入蒸馏水中，并加入Gd2O3并搅拌；第六步去除杂质和溶剂；第七步在甲醇中溶解并用乙腈沉淀得到固体。
• DERIVATES OF SUBSTITUTED TARTARIC AICD AND USAGE FOR PREPARATING BETA SECRETASE INHIBITORS
  申请人：Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China

  公开号：EP2116526B1

  公开（公告）日：2018-04-18
• N-(3-Triethoxysilylpropyl)-4-(isothiocyanatomethyl)-cyclohexane-1-carboxamide (TPICC): A heterobifunctional reagent for immobilization of biomolecules on glass surface
  作者：Arvind Misra、Mohammad Shahid、Pratibha Dwivedi

  DOI：10.1016/j.bmcl.2008.08.075

  日期：2008.10

  An efficient heterobifunctional reagent, N-(3-triethoxysilylpropyl)-4-(isothiocyanatomethyl) cyclohexane1-carboxamide (TPICC) has been developed by a simple 'two step reaction' for the preparation of bioconjugates and immobilization of biomolecules such as oligonucleotides, peptides and proteins on the glass surface. The isothiocyanate functionality at one end of the reagent, TPICC was found specific for the ligands having either aminoalkyl (RNH2) or me]rcaptoalkyl (R-SH) functionality. The synthesis of bioconjugates with the reagent was achieved through its isothiocyanate functionality at one end via the formation of stable thiourea linkage with aminoalkyl and dithiocarbamate linkage with mercaptoalkyl derivatives. The triethoxysilyl functionality of the reagent has been utilized for specific coupling with the virgin glass surface by a very simple methodology. (C) 2008 Elsevier Ltd. All rights reserved.
• Aminocarboxylic acids, amino alcohols, or the derivatives thereof, processes for production thereof, and pharmaceutical composition, containing at least one of these compounds
  申请人：TEIJIN LIMITED

  公开号：EP0044541B1

  公开（公告）日：1983-09-21