S-acetyl-N-(6-nitroveratryloxycarbonyl)-L-thiothreonine | 1373406-30-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: S-acetyl-N-(6-nitroveratryloxycarbonyl)-L-thiothreonine
• CAS: 1373406-30-4
• 化学式: C₁₆H₂₀N₂O₉S
• 分子量: 416.409
• InChiKey: FBOBZXGFWDFBGC-CLAHSXSESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.96
• 重原子数：
  28.0
• 可旋转键数：
  9.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  154.3
• 氢给体数：
  2.0
• 氢受体数：
  9.0

反应信息

• 作为反应物：
  描述：

  S-acetyl-N-(6-nitroveratryloxycarbonyl)-L-thiothreonine 在 三乙胺 、 lithium hydroxide 作用下， 以 甲醇 、 水 、 N,N-二甲基甲酰胺 、 乙腈 为溶剂， 反应 43.0h， 生成 S-(4,4'-dimethoxytrityl)-N-(6-nitroveratryloxycarbonyl)-L-thiothreonine cyanomethyl ester
  参考文献：
  名称：

  Synthesis of pdCpAs and transfer RNAs activated with thiothreonine and derivatives

  摘要：

  N,S-diprotected L-thiothreonine and L-allo-thiothreonine derivatives were synthesized using a novel chemical strategy, and used for esterification of the dinucleotide pdCpA. The aminoacylated dinucleotides were then employed for the preparation of activated suppressor tRNA(CUA) transcripts. Thiothreonine and allo-thiothreonine were incorporated into a predetermined position of a catalytically competent dihydrofolate reductase (DHFR) analogue lacking cysteine, and the elaborated proteins were derivatized site-specifically at the thiothreonine residue with a fluorophore. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2012.02.024
• 作为产物：
  描述：

  N-(6-nitroveratryloxycarbonyl)-L-allo-threonine 在 O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate 、 三乙胺 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 43.0h， 生成 S-acetyl-N-(6-nitroveratryloxycarbonyl)-L-thiothreonine
  参考文献：
  名称：

  Synthesis of pdCpAs and transfer RNAs activated with thiothreonine and derivatives

  摘要：

  N,S-diprotected L-thiothreonine and L-allo-thiothreonine derivatives were synthesized using a novel chemical strategy, and used for esterification of the dinucleotide pdCpA. The aminoacylated dinucleotides were then employed for the preparation of activated suppressor tRNA(CUA) transcripts. Thiothreonine and allo-thiothreonine were incorporated into a predetermined position of a catalytically competent dihydrofolate reductase (DHFR) analogue lacking cysteine, and the elaborated proteins were derivatized site-specifically at the thiothreonine residue with a fluorophore. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2012.02.024