4-<2-(2-furyl)-1,3-dithial-2-yl>dihydrofuran-2(3H)-one | 154244-33-4

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫代缩醛
• 英文名称: 4-<2-(2-furyl)-1,3-dithial-2-yl>dihydrofuran-2(3H)-one
• 英文别名: 4-[2-(2-furyl)-1,3-dithian-2-yl]tetrahydrofuran-2-one；4-[2-(Furan-2-yl)-1,3-dithian-2-yl]oxolan-2-one
• CAS: 154244-33-4
• 化学式: C₁₂H₁₄O₃S₂
• 分子量: 270.373
• InChiKey: JGGBMQZXDDAOHY-UHFFFAOYSA-N

物化性质

• 沸点：
  470.7±45.0 °C(predicted)
• 密度：
  1.346±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  90
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  4-<2-(2-furyl)-1,3-dithial-2-yl>dihydrofuran-2(3H)-one 在 三氟化硼乙醚 、 mercury(II) oxide 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 20.0h， 生成 4-(2-furoyl)dihydrofuran-2(3H)-one
  参考文献：
  名称：

  Medarde, Manuel; Ramos, Angel C.; Clairac, Rafael Pelaez-Lamamie de, Journal of the Chemical Society. Perkin transactions I, 1994, # 1, p. 45 - 48

  摘要：

  DOI：
• 作为产物：
  描述：

  2-(1,3-dithian-2-yl)furan 、 2(5H)-呋喃酮 在 正丁基锂 作用下， 以87%的产率得到4-<2-(2-furyl)-1,3-dithial-2-yl>dihydrofuran-2(3H)-one
  参考文献：
  名称：

  Medarde, Manuel; Ramos, Angel C.; Clairac, Rafael Pelaez-Lamamie de, Journal of the Chemical Society. Perkin transactions I, 1994, # 1, p. 45 - 48

  摘要：

  DOI：

文献信息

• Heterolignanolides. Furo- and thieno-analogues of podophyllotoxin and thuriferic acid
  作者：Angel C Ramos、Rafael Peláez、Jose Luis López、Esther Caballero、Manuel Medarde、Arturo San Feliciano

  DOI：10.1016/s0040-4020(01)00271-x

  日期：2001.4

  The conjugate addition-alkylation to 5H-furan-2-one followed by cyclization and controlled epimerizations have been applied to the synthesis of new furo- and thieno-lignan analogues. Podophyllotoxin and thuriferic acid heteroanalogues have been obtained by this methodology, as representative members of these families. (C) 2001 Elsevier Science Ltd. All rights reserved.
• Synthesis and cytotoxic activities of analogues of thuriferic acid
  作者：Blanca Madrigal、Pilar Puebla、Angel Ramos、Rafael Peláez、Dolores Grávalos、Esther Caballero、Manuel Medarde

  DOI：10.1016/s0968-0896(01)00280-2

  日期：2002.2

  Several analogues of thuriferic acid and derivatives, with the 3,4-methylenedioxyphenyl ring replaced by naphthalene, furan, thiophene and carbazole ring systems, have been prepared. The synthetic strategy is based on a conjugate addition alkylation methodology followed by cationic cyclization in order to obtain the isopodophyllone analogues, which are transformed in the thuriferic acids. Their cytotoxic activities against several tumour cells lines are also described. (C) 2001 Elsevier Science Ltd. All rights reserved.
• Medarde, Manuel; Ramos, Angel C.; Clairac, Rafael Pelaez-Lamamie de, Journal of the Chemical Society. Perkin transactions I, 1994, # 1, p. 45 - 48
  作者：Medarde, Manuel、Ramos, Angel C.、Clairac, Rafael Pelaez-Lamamie de、Caballero, Esther、Feliciano, Arturo San

  DOI：——

  日期：——