[(2R,3S,4R)-1,3,4-tris(phenylmethoxy)hex-5-en-2-yl] 3-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]propanoate | 536739-85-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [(2R,3S,4R)-1,3,4-tris(phenylmethoxy)hex-5-en-2-yl] 3-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]propanoate
• CAS: 536739-85-2
• 化学式: C₃₅H₄₂O₇
• 分子量: 574.714
• InChiKey: NDULJKMIECKYHD-FRSIXFHRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  42
• 可旋转键数：
  18
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  72.4
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  [(2R,3S,4R)-1,3,4-tris(phenylmethoxy)hex-5-en-2-yl] 3-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]propanoate 在 tri(cycloxexyl)phosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidene][benzylidene]ruthenium(IV) dichloride 、 lead(II) chloride 四甲基乙二胺 、 四氯化钛 、 锌 作用下， 以 四氢呋喃 、 二氯甲烷 、 甲苯 为溶剂， 反应 4.0h， 生成
  参考文献：
  名称：

  Synthesis of Some Biologically Relevant β-C-Glycoconjugates

  摘要：

  [GRAPHICS]An esterification-RCM approach to a variety of biologically relevant beta-C-glycoconjugates is reported herein. A range of carboxylic acids were coupled with several different olefin alcohols 1 to provide esters 3. The esters were then converted to the final ring-closed product 6 in three steps in 49-60% overall yield. The formed compounds are biologically relevant and serve as stable carbohydrate mimics of the corresponding O-glycosides.

  DOI：

  10.1021/ol034363q
• 作为产物：
  描述：

  (3R,4R,5R)-5-hydroxy-3,4,6-tribenzyloxy-1-hexene 、 (R)-3-(2,2-dimethyl-1,3-dioxolan-4-yl)propanoic acid 在 4-二甲氨基吡啶 、 N,N'-二环己基碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 反应 18.0h， 以94%的产率得到[(2R,3S,4R)-1,3,4-tris(phenylmethoxy)hex-5-en-2-yl] 3-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]propanoate
  参考文献：
  名称：

  Synthesis of Some Biologically Relevant β-C-Glycoconjugates

  摘要：

  [GRAPHICS]An esterification-RCM approach to a variety of biologically relevant beta-C-glycoconjugates is reported herein. A range of carboxylic acids were coupled with several different olefin alcohols 1 to provide esters 3. The esters were then converted to the final ring-closed product 6 in three steps in 49-60% overall yield. The formed compounds are biologically relevant and serve as stable carbohydrate mimics of the corresponding O-glycosides.

  DOI：

  10.1021/ol034363q

文献信息

• Synthesis of Some Biologically Relevant β-<i>C</i>-Glycoconjugates
  作者：Maarten H. D. Postema、Jared L. Piper

  DOI：10.1021/ol034363q

  日期：2003.5.1

  [GRAPHICS]An esterification-RCM approach to a variety of biologically relevant beta-C-glycoconjugates is reported herein. A range of carboxylic acids were coupled with several different olefin alcohols 1 to provide esters 3. The esters were then converted to the final ring-closed product 6 in three steps in 49-60% overall yield. The formed compounds are biologically relevant and serve as stable carbohydrate mimics of the corresponding O-glycosides.