3-imidazol-1-yl-N-phenylpropionamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-imidazol-1-yl-N-phenylpropionamide
• 英文别名: N-phenyl-3-(1H-imidazol-1-yl)propanamide；3-imidazol-1-yl-N-phenylpropanamide
• 化学式: C₁₂H₁₃N₃O
• mdl: MFCD24388783
• 分子量: 215.255
• InChiKey: TVLKGOFUEWJQID-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.166
• 拓扑面积：
  46.9
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-imidazol-1-yl-N-phenylpropionamide 、 二溴甲烷 以 四氢呋喃 为溶剂， 反应 72.0h， 以89.7%的产率得到1,1'-methylene-bis(3-N-phenylpropionamide-1H-imidazolium)dibromide
  参考文献：
  名称：

  Platinum(II) complexes with amide-functionalized NHC ligands

  摘要：

  We present the synthesis of neutral, amide-functionalized N-heterocyclic carbene (NHC) platinum(II) complexes with dianionic -N-C-NHC-C-NHC-N- (NC*C*N) tetradentate ligands. The imidazolium- and bisimidazolium bromide NHC ligand precursors with amide functionality in the side chain are reported together with the corresponding biscarbene bromido complexes and, after deprotonation, of the neutral NHC complexes without counterions. All compounds have been thoroughly characterized by standard techniques. (C) 2012 Elsevier B. V. All rights reserved.

  DOI：

  10.1016/j.jorganchem.2012.05.019
• 作为产物：
  描述：

  苯胺 在 三乙胺 作用下， 以 二氯甲烷 、 甲苯 为溶剂， 反应 2.0h， 生成 3-imidazol-1-yl-N-phenylpropionamide
  参考文献：
  名称：

  Platinum(II) complexes with amide-functionalized NHC ligands

  摘要：

  We present the synthesis of neutral, amide-functionalized N-heterocyclic carbene (NHC) platinum(II) complexes with dianionic -N-C-NHC-C-NHC-N- (NC*C*N) tetradentate ligands. The imidazolium- and bisimidazolium bromide NHC ligand precursors with amide functionality in the side chain are reported together with the corresponding biscarbene bromido complexes and, after deprotonation, of the neutral NHC complexes without counterions. All compounds have been thoroughly characterized by standard techniques. (C) 2012 Elsevier B. V. All rights reserved.

  DOI：

  10.1016/j.jorganchem.2012.05.019

文献信息

• Omega-((hetero)alkyl)benz(cd)-indol-2-amines
  申请人：American Cyanamid Company

  公开号：US05081131A1

  公开（公告）日：1992-01-14

  Omega-((hetero)alkyl)benz(cd)indol-2-amines useful in inhibition of thromboxane synthetase and in treatment of hypertension in warm-blooded animals are disclosed.

  本发明揭示了Omega-((hetero)烷基)苯并(cd)吲哚-2-胺，其在抑制血栓素合成酶和治疗温血动物的高血压方面具有用途。
• Omega-[(hetero)alkyl]benz[cd]indol-2-amines
  申请人：AMERICAN CYANAMID COMPANY

  公开号：EP0230035A2

  公开（公告）日：1987-07-29

  Omega-[(hetero)alkyl]benz[cd]indol-2-amines useful in inhibition of thromboxane synthetase and in treatment of hypertension in warm-blooded animals are disclosed.

  公开了可用于抑制血栓素合成酶和治疗温血动物高血压的ω-[（杂）烷基]苯并[cd]吲哚-2-胺。
• Synthesis and anticonvulsant activity of some ω-(1H-1-imidazolyl)-N-phenylalkanoic acid amide derivatives
  作者：Zeynep Aktürk、Fatma Kılıç、Kevser Erol、Varol Pabuçcuoğlu

  DOI：10.1016/s0014-827x(01)01197-1

  日期：2002.3

  In this study, 15 omega-(1H-imidazol-1-yl)-N-phenylacetamide, propionamide and butyramide derivatives having methoxyl, methyl, nitro and chloro in ortho position of N-phenyl ring or without any substituent have been realized by two-step synthesis. Their anticonvulsant activity was determined against seizures induced by maximal electroshock (MES). The most active compound in the series was 2-(1H-imidazol-1-yl)-N-(o-chlorophenyl)acetamide. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.
• US5081131A
  申请人：——

  公开号：US5081131A

  公开（公告）日：1992-01-14
• Platinum(II) complexes with amide-functionalized NHC ligands
  作者：Yvonne Unger、Thomas Strassner

  DOI：10.1016/j.jorganchem.2012.05.019

  日期：2012.8

  We present the synthesis of neutral, amide-functionalized N-heterocyclic carbene (NHC) platinum(II) complexes with dianionic -N-C-NHC-C-NHC-N- (NC*C*N) tetradentate ligands. The imidazolium- and bisimidazolium bromide NHC ligand precursors with amide functionality in the side chain are reported together with the corresponding biscarbene bromido complexes and, after deprotonation, of the neutral NHC complexes without counterions. All compounds have been thoroughly characterized by standard techniques. (C) 2012 Elsevier B. V. All rights reserved.