2,5-二甲基-4-羟基苯甲酸 | 27021-04-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2,5-二甲基-4-羟基苯甲酸
• 中文别名: 2,6-二甲基-4-羟基苯甲酸
• 英文名称: 4-hydroxy-2,5-dimethylbenzoic acid
• 英文别名: 4-Hydroxy-2,5-dimethyl-benzoesaeure；5-Oxy-1.4-dimethyl-benzol-carbonsaeure-(2)；4-Oxy-p-xylylsaeure
• CAS: 27021-04-1
• 化学式: C₉H₁₀O₃
• 分子量: 166.177
• InChiKey: NNZOKYRQPZZEAR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• 海关编码：
  2918290000

反应信息

• 作为反应物：
  描述：

  2,5-二甲基-4-羟基苯甲酸 在 吡啶 、 氯化亚砜 作用下， 以 二氯甲烷 为溶剂， 生成 Methyl 2,5-dimethyl-4-trifluoromethanesulfonyloxybenzoate
  参考文献：
  名称：

  3-(BIARYLOXY) PROPIONIC ACID DERIVATIVE

  摘要：

  公开号：

  EP2471792B1
• 作为产物：
  描述：

  2,2,2-trichloro-1-(4-hydroxy-2,5-dimethyl-phenyl)-ethanone 在 aqueous alkali 作用下， 生成 2,5-二甲基-4-羟基苯甲酸
  参考文献：
  名称：

  Volume measurement with magnetic resonance imaging of hippocampus-amygdala formation in patients with anorexia nervosa

  摘要：

  The purpose of our work was to evaluate the volume of hippocampus-amygdala formation (HAF) in patients with anorexia nervosa (AN), being this structure a crucial target for the glucocorticoid action in the adaptative stress-response. AN patients have biochemical hypercortisolism associated to normal ACTH levels, but do not develop the characteristic clinical features of glucocorticoid hypersecretion. Furthermore, in these patients cortisol levels usually do not suppress after dexametasone challenge. Twenty AN females (aged 30.0 +/-5.1) with 10.5 +/-4.2 yr of disease underwent a brain magnetic resonance (MR) examination during the recovery phase; an age-matched control group (CG) of 20 healthy female volunteers was also studied. Two interleaved T1-weighted spin-echo sequences for 46 contiguous 2-mm coronal slices (pixel 0.98(2) mm) were used. The volumes of both right and left HAFs were calculated with manual contouring from the third ventricle to the Sylvian aqueduct. IGF-I, T-3, gonadotropins, 24-h urine free cortisol, and BMI were obtained for both patients (on admission and on present evaluation) and CG. Mann-Whitney, Wilcoxon and Spearman tests were used. AN patients showed a significant (p=0.0001) reduction of total (right plus left) HAF volume (6.6 +/-1.3 cm(3)) when compared with CG (8.9 +/-1.1). No significant difference was found between right and left HAF in both patients and CG. In AN patients, no significant correlation was found between the HAF and all the hormonal parameters or BMIs, while a trend towards significance was observed with duration of the disease (r=-0.398; p=0.082). MR imaging demonstrated a significant volume reduction of HAF in AN patients during the recovery phase of the disease, suggesting a possible causal role in the pathogenesis of the disease. (J. Endocrinol. Invest. 24: 510-514, 2001) (C) 2001, Editrice Kurtis.

  DOI：

  10.1007/bf03343884

文献信息

• [EN] HIV PROTEASE INHIBITORS, COMPOSITIONS CONTAINING THE SAME AND THEIR PHARMACEUTICAL USES<br/>[FR] INHIBITEURS DE LA PROTEASE DU VIH, COMPOSITIONS LES CONTENANT ET LEURS UTILISATIONS PHARMACEUTIQUES
  申请人：PFIZER

  公开号：WO2005026114A1

  公开（公告）日：2005-03-24

  This invention relates to a novel series of chemical compounds useful as Human immunodeficiency Virus (HIV) protease inhibitors and to the use of such compounds as antiviral agents. The invention further relates to pharmaceutical compositions containing such antiviral agents, and their uses and materials for their synthesis

  这项发明涉及一类新型化合物系列，可用作人类免疫缺陷病毒（HIV）蛋白酶抑制剂，以及将这些化合物用作抗病毒剂的用途。该发明还涉及含有这种抗病毒剂的药物组合物，以及它们的用途和合成材料。
• Compounds
  申请人：Alcaraz Lilian

  公开号：US20090298807A1

  公开（公告）日：2009-12-03

  The present invention relates to spirocyclic amide derivatives of the formula I, pharmaceutically acceptable salts thereof, a process for their preparation, pharmaceutical compositions containing them, and their use in therapy.

  本发明涉及公式 I 的螺环酰胺衍生物，其药学上可接受的盐，其制备方法，含有它们的制药组合物以及它们在治疗中的应用。
• Fluorinated Dicarboxylic Acid Derivative and Polymer Obtained Therefrom
  申请人：Isono Yoshimi

  公开号：US20110301305A1

  公开（公告）日：2011-12-08

  According to the present invention, a polymer is obtained by polycondensation of a fluorinated dicarboxylic acid derivative of the general formula (M-1) or an acid anhydride of the fluorinated dicarboxylic acid with a polyfunctional compound having two to four reactive groups corresponding in reactivity to carbonyl moieties of the fluorinated dicarboxylic acid derivative or acid anhydride. [Chem. 134] AOCF 2 C-Q-CF 2 COA′  (M-1) In the above formula, Q represents a divalent organic group having a substituted or unsubstituted aromatic ring; and A and A′ each independently represent an organic group. This polymer exhibits a sufficiently low dielectric constant for use as a semiconductor protection film and has the capability of forming a film at a relatively low temperature of 250° C. or lower.

  根据本发明，通过将通式(M-1)的含氟二羧酸衍生物或含氟二羧酸酸酐与具有与含氟二羧酸衍生物或酸酐的羰基部分相对应的两到四个反应性基团的多官能化合物进行聚合缩合反应，可以得到一种聚合物。[Chem. 134]AOCF2C-Q-CF2COA′  (M-1)在上述公式中，Q代表具有取代或未取代芳香环的二价有机基团; A和A'各自独立地表示有机基团。该聚合物表现出足够低的介电常数，可用作半导体保护膜，并具有在相对较低的温度下（250℃或更低）形成膜的能力。
• Compouds
  申请人：Alcaraz Lilian

  公开号：US20120322788A1

  公开（公告）日：2012-12-20

  The present invention relates to spirocyclic amide derivatives of the formula I, pharmaceutically acceptable salts thereof, a process for their preparation, pharmaceutical compositions containing them, and their use in therapy.

  本发明涉及公式I的螺环酰胺衍生物，其药学上可接受的盐，其制备方法，含有它们的制药组合物以及它们在治疗中的用途。
• Organic Base-Mediated Carboxylation of (Hetero)aromatic Compounds Using Supercritical Carbon Dioxide (scCO2)
  作者：Thavendran Govender、Lloyd C. Chetty、Hendrik G. Kruger、Per I. Arvidsson、Tricia Naicker

  DOI：10.1055/a-1894-9073

  日期：2022.11

  A straightforward site-selective method for the direct carboxylation of resorcinols (3-hydroxyphenol derivatives), phenols, and indoles is reported. The products were obtained in moderate to high yields using supercritical carbon dioxide as an electrophile and solvent under basic conditions. This method offers solvent and metal free conditions without the cumbersome exclusion of air or water with convenient

  报道了一种用于间苯二酚（3-羟基苯酚衍生物）、苯酚和吲哚直接羧化的直接位点选择性方法。使用超临界二氧化碳作为亲电试剂和溶剂在碱性条件下以中等至高产率获得产物。这种方法提供了无溶剂和金属的条件，无需繁琐的排除空气或水，便于纯化。