2-{4-[2-(5-methyl-2-phenyloxazol-4-yl)ethoxy]phenoxy} propionic acid ethyl ester | 1026739-26-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-{4-[2-(5-methyl-2-phenyloxazol-4-yl)ethoxy]phenoxy} propionic acid ethyl ester
• 英文别名: Ethyl 2-[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenoxy]propanoate
• CAS: 1026739-26-3
• 化学式: C₂₃H₂₅NO₅
• 分子量: 395.455
• InChiKey: GOGYIWRHKPURAK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  29
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  70.8
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2-{4-[2-(5-methyl-2-phenyloxazol-4-yl)ethoxy]phenoxy} propionic acid ethyl ester 在 sodium hydroxide 作用下， 以 四氢呋喃 、 乙醇 为溶剂， 反应 1.0h， 以77%的产率得到2-{4-[2-(5-Methyl-2-phenyloxazol-4-yl)ethoxy]phenoxy}propionic Acid
  参考文献：
  名称：

  Design and Synthesis of 2-Methyl-2-{4-[2-(5-methyl-2-aryloxazol- 4-yl)ethoxy]phenoxy}propionic Acids:  A New Class of Dual PPARα/γ Agonists

  摘要：

  Propionic acid derivative 8, which was designed and synthesized based on putative pharmacophores of known PPAR gamma- and PPAR alpha -selective compounds, exhibits potent dual PPAR alpha/gamma agonist activity as demonstrated by in vitro binding and dose overlap in the newly introduced EOB mouse model for glucose lowering and lipid/cholesterol homeostasis.

  DOI：

  10.1021/jm0155188
• 作为产物：
  描述：

  4-[2-(4-benzyloxyphenoxy)ethyl]-5-methyl-2-phenyloxazole 在 palladium on activated charcoal 、 Cs₂O₃ 、 ammonium formate 作用下， 以 甲醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 26.0h， 生成 2-{4-[2-(5-methyl-2-phenyloxazol-4-yl)ethoxy]phenoxy} propionic acid ethyl ester
  参考文献：
  名称：

  Design and Synthesis of 2-Methyl-2-{4-[2-(5-methyl-2-aryloxazol- 4-yl)ethoxy]phenoxy}propionic Acids:  A New Class of Dual PPARα/γ Agonists

  摘要：

  Propionic acid derivative 8, which was designed and synthesized based on putative pharmacophores of known PPAR gamma- and PPAR alpha -selective compounds, exhibits potent dual PPAR alpha/gamma agonist activity as demonstrated by in vitro binding and dose overlap in the newly introduced EOB mouse model for glucose lowering and lipid/cholesterol homeostasis.

  DOI：

  10.1021/jm0155188

文献信息

• Design and Synthesis of 2-Methyl-2-{4-[2-(5-methyl-2-aryloxazol- 4-yl)ethoxy]phenoxy}propionic Acids:  A New Class of Dual PPARα/γ Agonists
  作者：Dawn A. Brooks、Garret J. Etgen、Christopher J. Rito、Anthony J. Shuker、Samuel J. Dominianni、Alan M. Warshawsky、Robert Ardecky、James R. Paterniti、John Tyhonas、Donald S. Karanewsky、Raymond F. Kauffman、Carol L. Broderick、Brian A. Oldham、Chahzrad Montrose-Rafizadeh、Leonard L. Winneroski、Margaret M. Faul、James R. McCarthy

  DOI：10.1021/jm0155188

  日期：2001.6.1

  Propionic acid derivative 8, which was designed and synthesized based on putative pharmacophores of known PPAR gamma- and PPAR alpha -selective compounds, exhibits potent dual PPAR alpha/gamma agonist activity as demonstrated by in vitro binding and dose overlap in the newly introduced EOB mouse model for glucose lowering and lipid/cholesterol homeostasis.