1-(金刚烷-1-羰基)吡咯烷-2-酮 | 139143-53-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 中文名称: 1-(金刚烷-1-羰基)吡咯烷-2-酮
• 英文名称: 1-(adamantane-1-carbonyl)pyrrolidin-2-one
• CAS: 139143-53-6
• 化学式: C₁₅H₂₁NO₂
• 分子量: 247.337
• InChiKey: HGLVVWKWAQKMAH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.87
• 拓扑面积：
  37.4
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 海关编码：
  2933790090

反应信息

• 作为反应物：
  描述：

  1-(金刚烷-1-羰基)吡咯烷-2-酮 在 sodium tetrahydroborate 、 溶剂黄146 、 calcium oxide 作用下， 以 甲醇 为溶剂， 反应 4.0h， 生成 2-(1-金刚烷基)吡咯烷盐酸盐
  参考文献：
  名称：

  Synthesis and Antiviral Activity Evaluation of Some New Aminoadamantane Derivatives. 2

  摘要：

  The synthesis of some new aminoadamantane derivatives is described. The new compounds were evaluated against a wide range of viruses [influenza A H1N1, influenza A H2N2, influenza A H3N2, influenza B, parainfluenza 3, herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2), thymidine kinase-deficient (TK-) HSV-1, vaccinia, vesicular stomatitis, polio 1, Coxsackie B4, Sindbis, Semliki forest, Reo 1, varicella-zoster virus (VZV), TK- VZV, human cytomegalo-virus (HCMV),,and human immunodeficiency virus type 1 (HIV-1) and type 2 (HIV-2)]. Some of them proved markedly active against the influenza A H2N2 (compounds 4a,b, 5a, 6a, and 7a), H3N2 (compounds 5a, 6a, and 7a), and H1N1 (compounds 4b,c and 6d). Since compounds 5a, 6a, and 7a, amantadine, and rimantadine showed the same comparative pattern of potency against influenza strains H2N2, H3N2, and B, it may postulated that they act according to a similar mechanism, with regard to their ''amine'' effect, on the M2 ion channel of influenza A (H1N1, H2N2, or H3N2). In general, no significant activity was noted with any of the new compounds against any of the other viruses tested, making their activity against influenza virus more specific and striking. Borderline activity was noted with some of the compounds (4b,c, 5a-c, and 8a) against HIV-1.

  DOI：

  10.1021/jm950891z
• 作为产物：
  描述：

  1-三甲基硅基吡咯酮 、 金刚烷酰氯 以 四氢呋喃 为溶剂， 反应 7.0h， 以93.6%的产率得到1-(金刚烷-1-羰基)吡咯烷-2-酮
  参考文献：
  名称：

  Synthesis and Antiviral Activity Evaluation of Some New Aminoadamantane Derivatives. 2

  摘要：

  The synthesis of some new aminoadamantane derivatives is described. The new compounds were evaluated against a wide range of viruses [influenza A H1N1, influenza A H2N2, influenza A H3N2, influenza B, parainfluenza 3, herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2), thymidine kinase-deficient (TK-) HSV-1, vaccinia, vesicular stomatitis, polio 1, Coxsackie B4, Sindbis, Semliki forest, Reo 1, varicella-zoster virus (VZV), TK- VZV, human cytomegalo-virus (HCMV),,and human immunodeficiency virus type 1 (HIV-1) and type 2 (HIV-2)]. Some of them proved markedly active against the influenza A H2N2 (compounds 4a,b, 5a, 6a, and 7a), H3N2 (compounds 5a, 6a, and 7a), and H1N1 (compounds 4b,c and 6d). Since compounds 5a, 6a, and 7a, amantadine, and rimantadine showed the same comparative pattern of potency against influenza strains H2N2, H3N2, and B, it may postulated that they act according to a similar mechanism, with regard to their ''amine'' effect, on the M2 ion channel of influenza A (H1N1, H2N2, or H3N2). In general, no significant activity was noted with any of the new compounds against any of the other viruses tested, making their activity against influenza virus more specific and striking. Borderline activity was noted with some of the compounds (4b,c, 5a-c, and 8a) against HIV-1.

  DOI：

  10.1021/jm950891z

文献信息

• Metal-free transamidation of benzoylpyrrolidin-2-one and amines under aqueous conditions
  作者：Devaneyan Joseph、Myeong Seong Park、Sunwoo Lee

  DOI：10.1039/d1ob00967b

  日期：——

  in the presence of DTBP and TBAI to afford the transamidated products in good yields. The reactions were conducted under aqueous conditions and good functional group tolerance was achieved. Both aliphatic and aromatic primary amines displayed good activity under metal-free conditions. A radical reaction pathway is proposed.

  N-酰基内酰胺酰胺，如苯甲酰吡咯烷-2-酮、苯甲酰哌啶-2-酮和苯甲酰西泮-2-酮在DTBP和TBAI存在下与胺反应，以良好的收率得到转酰胺基产物。该反应在水性条件下进行，并获得了良好的官能团耐受性。脂肪族和芳香族伯胺在无金属条件下均表现出良好的活性。提出了一种自由基反应途径。
• SET or TET? Iron-catalyzed aminocarbonylation of unactivated alkyl halides with amines, amides, and indoles via a substrate dependent mechanism
  作者：Han-Jun Ai、Fengqian Zhao、Xiao-Feng Wu

  DOI：10.1016/s1872-2067(22)64208-6

  日期：2023.4

  abundance, and potential for distinct and complementary reactivity patterns. Meanwhile, alkyl bromides as well as low nucleophilic amides and indoles are considered to be particularly challenge substrates for carbonylation reactions. Herein, we report an iron-catalyzed carbonylative coupling of unactivated alkyl halides with amines, amides, and indoles to assemble amide structural units, affording various

  铁催化的羰基化反应在我们倡导可持续发展的化学界非常受欢迎，因为它成本低、资源丰富，并且具有独特和互补反应模式的潜力。同时，烷基溴以及低亲核性酰胺和吲哚被认为是羰基化反应特别具有挑战性的底物。在此，我们报告了未活化的烷基卤化物与胺、酰胺和吲哚的铁催化羰基化偶联以组装酰胺结构单元，提供各种酰胺、酰亚胺和N- 具有优异产率和前所未有的官能团相容性的酰基吲哚。值得注意的是，我们的方法也代表了 Fe 催化的卤代烷氨基羰基化的例子。我们的初步机理研究表明反应途径是底物依赖性的：当使用烷基碘时，羰基化通过自由基途径进行；而当烷基溴化物作为亲电子试剂时，会发生双电子转移 (TET) 过程。
• Onium salt, chemically amplified resist composition, and patterning process
  申请人：Shin-Etsu Chemical Co., Ltd.

  公开号：US11333974B2

  公开（公告）日：2022-05-17

  A novel onium salt and a resist composition comprising the same as a PAG are provided. When processed by photolithography using KrF or ArF excimer laser, EB or EUV, the resist composition is reduced in acid diffusion and improved in exposure latitude, MEF, and LWR.

  本发明提供了一种新型铌盐和由其作为 PAG 组成的抗蚀剂组合物。在使用 KrF 或 ArF 准分子激光、EB 或 EUV 进行光刻处理时，抗蚀剂组合物的酸扩散性降低，曝光纬度、MEF 和 LWR 提高。
• NOVEL ONIUM SALT, CHEMICALLY AMPLIFIED RESIST COMPOSITION, AND PATTERNING PROCESS
  申请人：Shin-Etsu Chemical Co., Ltd.

  公开号：US20200133122A1

  公开（公告）日：2020-04-30

  A novel onium salt and a resist composition comprising the same as a PAG are provided. When processed by photolithography using KrF or ArF excimer laser, EB or EUV, the resist composition is reduced in acid diffusion and improved in exposure latitude, MEF, and LWR.
• Synthesis and Antiviral Activity Evaluation of Some New Aminoadamantane Derivatives. 2
  作者：Nicolas Kolocouris、Antonios Kolocouris、George B. Foscolos、George Fytas、Johan Neyts、Elisabeth Padalko、Jan Balzarini、Robert Snoeck、Graciela Andrei、Erik De Clercq

  DOI：10.1021/jm950891z

  日期：1996.1.1

  The synthesis of some new aminoadamantane derivatives is described. The new compounds were evaluated against a wide range of viruses [influenza A H1N1, influenza A H2N2, influenza A H3N2, influenza B, parainfluenza 3, herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2), thymidine kinase-deficient (TK-) HSV-1, vaccinia, vesicular stomatitis, polio 1, Coxsackie B4, Sindbis, Semliki forest, Reo 1, varicella-zoster virus (VZV), TK- VZV, human cytomegalo-virus (HCMV),,and human immunodeficiency virus type 1 (HIV-1) and type 2 (HIV-2)]. Some of them proved markedly active against the influenza A H2N2 (compounds 4a,b, 5a, 6a, and 7a), H3N2 (compounds 5a, 6a, and 7a), and H1N1 (compounds 4b,c and 6d). Since compounds 5a, 6a, and 7a, amantadine, and rimantadine showed the same comparative pattern of potency against influenza strains H2N2, H3N2, and B, it may postulated that they act according to a similar mechanism, with regard to their ''amine'' effect, on the M2 ion channel of influenza A (H1N1, H2N2, or H3N2). In general, no significant activity was noted with any of the new compounds against any of the other viruses tested, making their activity against influenza virus more specific and striking. Borderline activity was noted with some of the compounds (4b,c, 5a-c, and 8a) against HIV-1.