N,N-dibenzyl-2-methyl-5-decyn-4-amine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N,N-dibenzyl-2-methyl-5-decyn-4-amine
• 英文别名: N,N-dibenzyl-2-methyldec-5-yn-4-amine
• 化学式: C₂₅H₃₃N
• 分子量: 347.544
• InChiKey: ZZGXKMLVCPJTFC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.1
• 重原子数：
  26
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  异戊醛 在 disodium hydrogenphosphate 、 copper(l) chloride 、 copper(I) bromide 作用下， 以 四氢呋喃 、 甲苯 为溶剂， 反应 72.0h， 生成 N,N-dibenzyl-2-methyl-5-decyn-4-amine
  参考文献：
  名称：

  Copper(I)-Catalysed Deacetylenative Cross-Coupling Reaction of Terminal Alkynes with Propargylic Amines via C(sp)-C(sp3) Bond Cleavage

  摘要：

  The catalytic deacetylenative coupling reaction of terminal alkynes with various N-substituted propargylic amines proceeded in the presence of CuCl (10 mol%) and Na2HPO4 (4 equiv) in THF at 130 degrees C to give the corresponding substituted propargylic amines in good to high yields.

  DOI：

  10.1055/s-0031-1290376

文献信息

• Monophosphine compound, transition metal complex thereof and production method of optically active compound using the complex as asymmetric catalyst
  申请人：Carreira M. Erick

  公开号：US20050277772A1

  公开（公告）日：2005-12-15

  The present invention provides a compound represented by the formula (I): wherein ring A is void or a benzene ring optionally having substituent(s), R 1 and R 2 are each independently a phenyl group optionally having substituent(s), a cyclohexyl group and the like, R 3 and R 4 are each independently a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group and the like, and X is a residue represented by —OR 5 or —NHR 6 wherein R 5 and R 6 are a lower alkyl group optionally having substituent(s), an aralkyl group optionally having substituent(s) and the like, a asymmetric transition metal complex containing the compound as a ligand and a production method of optically active compound using the complex as an asymmetric catalyst.

  本发明提供了一种由以下式（I）表示的化合物： 其中环A为空或是一个苯环，可选地具有取代基，R1和R2分别独立地是一个苯基，可选地具有取代基，一个环己基等，R3和R4分别独立地是一个氢原子，一个卤原子，一个低碳基团，一个低碳氧基团等，X是由—OR5或—NHR6表示的残基，其中R5和R6是一个低碳基团，可选地具有取代基，一个芳基烷基团，可选地具有取代基等，一种含有该化合物作为配体的不对称过渡金属配合物以及使用该配合物作为不对称催化剂的光学活性化合物的生产方法。
• Synthesis of Enantiomerically Enriched Propargylamines by Copper-Catalyzed Addition of Alkynes to Enamines
  作者：Christopher Koradin、Nina Gommermann、Kurt Polborn、Paul Knochel

  DOI：10.1002/chem.200204691

  日期：2003.6.16

  The first copper(I) bromide/Quinap-catalyzed synthesis of enantiomerically enriched propargylamines by addition of alkynes to enamines is reported. Various functionalized terminal alkynes add smoothly to Nprotected enamines to afford the corresponding amines in good to high yields and moderate to good enantiomeric excesses. The influence of the metal salt, the ligand, and the protecting group on the

  报道了通过将炔烃加到烯胺中的第一对溴化铜（I）/奎纳普催化的对映体富集的炔丙基胺的合成。各种官能化的末端炔烃平稳地添加到N保护的烯胺中，以高至高收率和中度至良好的对映体过量提供相应的胺。研究了金属盐，配体和保护基对转化率，反应速率和反应立体选择性的影响。还描述了反应的范围和所得炔丙基胺的进一步转化（脱保护，Pauson-Khand反应）。
• MONOPHOSPHINE COMPOUNDS, TRANSITION METAL COMPLEXES THEREOF AND PRODUCTION OF OPTICALLY ACTIVE COMPOUNDS USING THE COMPLEXES AS ASYMMETRIC CATALYSTS
  申请人：Sumitomo Chemical Company, Limited

  公开号：EP1773853A1

  公开（公告）日：2007-04-18
• US7790882B2
  申请人：——

  公开号：US7790882B2

  公开（公告）日：2010-09-07
• [EN] MONOPHOSPHINE COMPOUNDS, TRANSITION METAL COMPLEXES THEREOF AND PRODUCTION OF OPTICALLY ACTIVE COMPOUNDS USING THE COMPLEXES AS ASYMMETRIC CATALYSTS<br/>[FR] COMPOSES DE MONOPHOSPHINE, COMPLEXES DE METAUX DE TRANSITION ASSOCIES ET PRODUCTION DE COMPOSES ACTIFS SUR LE PLAN OPTIQUE AU MOYEN DESDITS COMPLEXES EN TANT QUE CATALYSEURS ASYMETRIQUES
  申请人：SUMITOMO CHEMICAL CO

  公开号：WO2005121157A1

  公开（公告）日：2005-12-22

  The present invention provides a compound represented by the formula (I): wherein ring A is void or a benzene ring optionally having substituent(s), R1 and R2 are each independently a phenyl group optionally having substituent(s), a cyclohexyl group and the like, R3 and R4 are each independently a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group and the like, and X is a residue represented by -OR5 or -NHR6 wherein R5 and R6 are a lower alkyl group optionally having substituent(s), an aralkyl group optionally having substituent(s) and the like, a asymmetric transition metal complex containing the compound as a ligand and a production method of optically active compound using the complex as an asymmetric catalyst.