Gold(I)-Catalyzed Intramolecular Hydroarylation of Phenol-Derived Propiolates and Certain Related Ethers as a Route to Selectively Functionalized Coumarins and 2<i>H</i>-Chromenes
作者:Aymeric Cervi、Yen Vo、Christina L. L. Chai、Martin G. Banwell、Ping Lan、Anthony C. Willis
DOI:10.1021/acs.joc.0c02011
日期:2021.1.1
Methods are reported for the efficient assembly of a series of phenol-derived propiolates, including the parent system 56, and their Au(I)-catalyzed cyclization (intramolecular hydroarylation) to give the corresponding coumarins (e.g., 1). Simple syntheses of naturalproducts such as ayapin (144) and scoparone (145) have been realized by such means, and the first of these subject to single-crystal
The reaction of acetophenones with iodine(III) tris(trifluoroacetate) yields 3′- and/or 2-iodo derivatives, depending upon the substituent on the aromatic ring and the reaction conditions. The reaction was examined by changing the molar ratio of acetophenone versus the reagent, reaction temperature, and solvent. In similar reactions flavanones and coumarins gave iodo derivatives in which iodine is incorporated
What knowledge is important to a software professional?
作者:T.C. Lethbridge
DOI:10.1109/2.841783
日期:2000.5
Efforts to develop licensing requirements, curricula, or training programs for software professionals should consider the experience of the practitioners who actually perform the work. We surveyed software professionals representing a wide variety of industries, job functions, and countries to learn which educational topics have proved most important to them in their careers and to identify the topics for which their education or current knowledge could be improved.
Platinum‐Catalyzed Desaturation of Lactams, Ketones, and Lactones
作者:Ming Chen、Alexander J. Rago、Guangbin Dong
DOI:10.1002/anie.201811197
日期:2018.12.3
desaturation of N‐protected lactams, ketones, and lactones to their conjugated α,β‐unsaturated counterparts is reported. The reaction operates under mildly acidic conditions at room temperature or 50 °C. It is scalable and tolerates a wide range of functional groups. The complementary reactivity to the palladium‐catalyzed desaturation is demonstrated in the efficient conversion of iodide, bromide, and sulfur‐containing
[EN] USE OF COMPOSITIONS MODULATING CHROMATIN STRUCTURE FOR GRAFT VERSUS HOST DISEASE (GVHD)<br/>[FR] UTILISATION DE COMPOSITIONS MODULANT LA STRUCTURE DE LA CHROMATINE CONTRE LA MALADIE DU GREFFON CONTRE L'HÔTE (GVHD)
申请人:DANA FARBER CANCER INST INC
公开号:WO2016073903A1
公开(公告)日:2016-05-12
In some aspects, the instant disclosure relates to methods of treating chronic graft versus host disease (cGVHD). In some embodiments, the method comprises administering to a subject in need thereof a EZH2 inhibitor, a Bcl6 inhibitor and/or BRD4 inhibitor. The present disclosure is based, at least in part, on the discovery that enhancer of zeste homolog 2 (EZH2) inhibitors, B-cell lymphoma 6 protein (Bcl6) inhibitors and/or bromodomain-containing protein 4 (BRD4) inhibitors can be used to treat chronic graft versus host disease (cGVHD).