2-oxo-4-chloromethyl-1,3,2-dioxaphospholane | 91114-68-0

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: 2-oxo-4-chloromethyl-1,3,2-dioxaphospholane
• 英文别名: 4-chloromethyl-2-oxo-2λ⁵-[1,3,2]dioxaphospholane；4-Chlormethyl-2-oxo-2λ⁵-[1,3,2]dioxaphospholan；Phosphonsaeure-(3-chlor-propylenester)；Phosphorigsaeure-(chlormethyl-aethylenester)；(3-Chlor-propylen)-phosphit
• CAS: 91114-68-0
• 化学式: C₃H₆ClO₃P
• 分子量: 156.506
• InChiKey: XMXPPVFVRGGQJE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.03
• 重原子数：
  8.0
• 可旋转键数：
  1.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  35.53
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为产物：
  描述：

  2-oxo-2-chloro-4-chloromethyl-1,3,2-dioxaphospholane 在 水 作用下， 生成 2-oxo-4-chloromethyl-1,3,2-dioxaphospholane
  参考文献：
  名称：

  Synthesis of Mixed Dialkylphosphates by PTC

  摘要：

  DOI：

  10.1080/10426500213344

文献信息

• [EN] METHOD FOR THE SYNTHESIS OF HETEROCYCLIC HYDROGEN PHOSPHINE OXIDE<br/>[FR] PROCÉDÉ POUR LA SYNTHÈSE D'UN OXYDE DE D'HYDROGÉNOPHOSPHINE HÉTÉROCYCLIQUE
  申请人：STRAITMARK HOLDING AG

  公开号：WO2016026871A1

  公开（公告）日：2016-02-25

  The present invention is related to a method for the synthesis of a heterocyclic hydrogen phosphine oxide, having the general formula (I), wherein: - R is a aliphatic or aromatic divalent group optionally comprising one or more heteroatoms and optionally comprising one or more substituents and - X and Y are independently selected from -O-, -C(O)O- and -NR'- wherein R' is a monovalent group optionally comprising one or more heteroatoms comprising the steps of: a) forming a reaction mixture by mixing a compound having the general formula HX-R-YH and tetraphosphorus hexaoxide; b) recovering the resulting compound comprising the heterocyclic hydrogen phosphine oxide.

  本发明涉及一种合成杂环氢膦氧化物的方法，其具有通式（I），其中：- R是一种脂肪或芳香双价基团，可选地包含一个或多个杂原子，也可选地包含一个或多个取代基；- X和Y分别选自-O-，-C（O）O-和-NR'-，其中R'是一种可选地包含一个或多个杂原子的单价基团，包括以下步骤：a）通过混合具有通式HX-R-YH和六氧化四磷的化合物形成反应混合物；b）回收包含杂环氢膦氧化物的所得化合物。
• New method of alkylene phosphonate preparation
  作者：Pawel Klosinski

  DOI：10.1016/s0040-4039(00)88906-6

  日期：1990.1

  A new method of alkylene phosphonate preparation has been elaborated, based on the reaction of the corresponding cyclic ethers and phosphonic acid in the presence of acetic anhydride.

  基于相应的环醚与膦酸在乙酸酐存在下的反应，详细阐述了一种制备亚烷基膦酸酯的新方法。
• SYNTHESIS OF CYCLIC PHOSPHOROUS ACID ESTERS BY TRANSESTERIFICATION
  作者：Alexis A. Oswald

  DOI：10.1139/v59-220

  日期：1959.9.1

  Five- and six-membered cyclic phosphorous acid esters were synthesized by transesterification of phosphites with 1,2- and 1,3-glycols: Diethyl hydrogen phosphite was transesterified to give cyclic hydrogen phosphites. Partial transesterification of tris-2-chloroethyl phosphite resulted in cyclic 2-chloroethyl phosphites.

  五元和六元环状亚磷酸酯是通过亚磷酸酯与 1,2- 和 1,3- 二醇的酯交换反应合成的： 亚磷酸氢二乙酯被酯交换得到环状亚磷酸氢酯。亚磷酸三-2-氯乙基酯的部分酯交换产生环状亚磷酸2-氯乙基酯。
• Arbusow; Soroastrowa; Rispoloshenski, Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1948, p. 208
  作者：Arbusow、Soroastrowa、Rispoloshenski

  DOI：——

  日期：——
• H-TETRAOXASPIROPHOSPHORANES AS POSSIBLE INTERMEDIATES IN THE PHOSPHONYLATION BY PHOSPHOROUS ACID/OXIRANES
  作者：Svetomir B. Tzokov、Nikolay G. Vassilev、Rositza T. Momtcheva、Jose Kaneti、Dimiter D. Petkova

  DOI：10.1080/10426500008076540

  日期：2000.1.1

  The detailed P-31-NMR study of the mechanism of the ribozymomimetic phosphorylation with phosphorous acid / oxirane revealed consecutive formation of beta -hydroxy H-phosphonate monoester, di-(beta -hydroxyalkyl) H-phosphonate, alkylene H-phosphonate, beta -hydroxy alkyl alkylene phosphite and the corresponding stereoelectronically stabilized penracoordinated H-tetraoxaspirophosphorane. The equilibrium between the triphosphite and the spirophosphorane shifts towards the beta -hydroxyalkyl alkylene phosphite at high temperatures. In the presence of alcohol and controlled amounts of water transesterification of the beta -hydroxyalkyl alkylene phosphite to the corresponding alkyl alkylene phosphite, and hydrolysis to beta -hydroxyalkyl alkyl H-phosphonate proceed at the elevated temperature. beta -Hydroxyalkyl alkyl H-phosphonates are model compounds of the phosphodiester bond and undergo hydrolysis with a diol leaving in the presence of one equivalent of water.