N-cycloheptyl-N'-cyclohexylthiourea | 60006-95-3

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫脲类
• 英文名称: N-cycloheptyl-N'-cyclohexylthiourea
• 英文别名: 1-cycloheptyl-3-cyclohexylthiourea
• CAS: 60006-95-3
• 化学式: C₁₄H₂₆N₂S
• mdl: MFCD07059051
• 分子量: 254.44
• InChiKey: MLXRYNHACPZSOF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.928
• 拓扑面积：
  56.2
• 氢给体数：
  2
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3-(chloromethyl)-5,6-dihydroimidazo[2,1-b]thiazole hydrochloride 、 N-cycloheptyl-N'-cyclohexylthiourea 以 乙腈 为溶剂， 生成
  参考文献：
  名称：

  Orally Bioavailable Isothioureas Block Function of the Chemokine Receptor CXCR4 In Vitro and In Vivo

  摘要：

  The interaction of the chemokine receptor CXCR4 with its ligand CXCL12 is involved in many biological processes such as hematopoesis, migration of immune cells, as well as in cancer metastasis. CXCR4 also mediates the infection of T-cells with X4-tropic HIV functioning as a coreceptor for the viral envelope protein gp120. Here, we describe highly potent, selective CXCR4 inhibitors that block CXCR4/CXCL12 interactions in vitro and in vivo Lis well as the infection of target cells by X4-tropic HIV.

  DOI：

  10.1021/jm801065q
• 作为产物：
  描述：

  环庚胺 、 环己基异硫氰酸脂 生成 N-cycloheptyl-N'-cyclohexylthiourea 、 硫脲
  参考文献：
  名称：

  Substituted morpholine guanidines for the treatment of arrhythmic

  摘要：

  以下化合物的药物组合物和使用这些组合物的方法用于抗心律失常和利尿作用的披露：##EQU1##

  公开号：

  US03961056A1

文献信息

• US3961056A
  申请人：——

  公开号：US3961056A

  公开（公告）日：1976-06-01
• Orally Bioavailable Isothioureas Block Function of the Chemokine Receptor CXCR4 In Vitro and In Vivo
  作者：Gebhard Thoma、Markus B. Streiff、Jiri Kovarik、Fraser Glickman、Trixie Wagner、Christian Beerli、Hans-Günter Zerwes

  DOI：10.1021/jm801065q

  日期：2008.12.25

  The interaction of the chemokine receptor CXCR4 with its ligand CXCL12 is involved in many biological processes such as hematopoesis, migration of immune cells, as well as in cancer metastasis. CXCR4 also mediates the infection of T-cells with X4-tropic HIV functioning as a coreceptor for the viral envelope protein gp120. Here, we describe highly potent, selective CXCR4 inhibitors that block CXCR4/CXCL12 interactions in vitro and in vivo Lis well as the infection of target cells by X4-tropic HIV.
• Substituted morpholine guanidines for the treatment of arrhythmic
  申请人：The Upjohn Company

  公开号：US03961056A1

  公开（公告）日：1976-06-01

  The pharmaceutical compositions and methods of using these compositions for anti-arrhythmic and diuretic uses are disclosed for the compounds below: ##EQU1##

  以下化合物的药物组合物和使用这些组合物的方法用于抗心律失常和利尿作用的披露：##EQU1##