1,3-丙二醇二对硝基苯甲酸酯 | 57609-63-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 1,3-丙二醇二对硝基苯甲酸酯
• 英文名称: 1,3-bis(4-nitrobenzoyloxy)propane
• 英文别名: 1,3-bis-(4-nitro-benzoyloxy)-propane；1,3-Bis-(4-nitro-benzoyloxy)-propan；Trimethylenglykol-bis-(4-nitro-benzoat)；1,3-Propanediol, bis(4-nitrobenzoate)；3-(4-nitrobenzoyl)oxypropyl 4-nitrobenzoate
• CAS: 57609-63-9
• 化学式: C₁₇H₁₄N₂O₈
• 分子量: 374.307
• InChiKey: DGEHMXCYTLBOBT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  27
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  144
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  1,3-丙二醇二对硝基苯甲酸酯 在 palladium 10% on activated carbon 、 氢气 作用下， 以 乙酸乙酯 为溶剂， 反应 12.0h， 以2265 mg的产率得到1,3-丙二醇双(4-氨基苯甲酸酯)
  参考文献：
  名称：

  统计数据放大了产品对映体纯度的有机催化双Ugi反应：一种连接物裂解方法，可得到高度对映纯的Ugi产品。

  摘要：

  在这里，我们报告了有机催化双重Ugi反应，在单个操作中将对映选择性过程和ee增强相结合，以提供具有非常高ee值的手性Ugi产品。设计分别由碳酸酯和二酯束缚的双异氰化物和双苯胺，以完成这种双多组分反应，形成10个新的化学键（4个CN，2个CC，2个CO和2个NH键）。该策略进一步用于对映体富集的大环化合物的快速构建。

  DOI：

  10.1021/acs.orglett.9b04239
• 作为产物：
  描述：

  1,3-丙二醇 生成 1,3-丙二醇二对硝基苯甲酸酯
  参考文献：
  名称：

  Fischer et al., Chemische Berichte, 1931, vol. 64, p. 611,613

  摘要：

  DOI：

文献信息

• Synthesis, characterization and morphological studies of some novel siloxane-based block copolymeric materials containing organometallic as well as organic polyesteramides
  作者：Muhammad Saif Ullah Khan、Zareen Akhter、Naseer Iqbal、Mohammad Siddiq

  DOI：10.1016/j.jorganchem.2013.08.002

  日期：2013.11

  A series of semi-aromatic diamine monomers (1,m-bis (4-amino benzoyloxy) alkanes; m = 2-6) having in-built ester linkages with variable methylene spacers were synthesized in two steps from aliphatic diols and p-nitrobenzoyl chloride and characterized by their melting points, elemental analysis, FTIR, H-1 and C-13 NMR spectroscopic studies. The diamines were then polymerized in-situ with ferrocene-based organometallic and terephthaloyl-as well as isophthaloyl-based organic acyl chlorides along with telechelic polydimethylsiloxane oligomer to produce a novel set of ferrocene-containing siloxane-based block copolymers and their organic analogues. The corresponding polyesteramides of the synthesized copolymers, without siloxane segment, were also prepared for comparative studies. The structural features of the organometallic and organic block copolymers along with their respective polyesteramides were confirmed by their physical properties and spectroscopic studies. The molecular parameters of all these materials were determined by static laser light scattering (LLS) technique and glass transition temperatures (T-g) were obtained by differential scanning calorimetry (DSC). The materials were soluble in sulphuric acid and partially soluble in common organic solvents at room temperature, yet become readily soluble upon N-trifluoroacetylation. The morphological information of the synthesized materials was obtained by X-ray diffraction and surface studies (SEM and AFM). (C) 2013 Elsevier B.V. All rights reserved.
• Fischer,E., Chemische Berichte, 1920, vol. 53, p. 1641
  作者：Fischer,E.

  DOI：——

  日期：——
• US3932360A
  申请人：——

  公开号：US3932360A

  公开（公告）日：1976-01-13
• US4283549A
  申请人：——

  公开号：US4283549A

  公开（公告）日：1981-08-11
• Organocatalytic Double Ugi Reaction with Statistical Amplification of Product Enantiopurity: A Linker Cleavage Approach To Access Highly Enantiopure Ugi Products
  作者：Qi-Yun Feng、Jieping Zhu、Mei-Xiang Wang、Shuo Tong

  DOI：10.1021/acs.orglett.9b04239

  日期：2020.1.17

  Here we report an organocatalytic double Ugi reaction combining the enantioselective process and ee enhancement in a single operation to afford the chiral Ugi products with very high ee values. Both bisisocyanides and bisanilines tethered by carbonate and diester, respectively, were designed to accomplish this double multicomponent reaction that formed 10 new chemical bonds (4 C-N, 2 C-C, 2 C-O, and

  在这里，我们报告了有机催化双重Ugi反应，在单个操作中将对映选择性过程和ee增强相结合，以提供具有非常高ee值的手性Ugi产品。设计分别由碳酸酯和二酯束缚的双异氰化物和双苯胺，以完成这种双多组分反应，形成10个新的化学键（4个CN，2个CC，2个CO和2个NH键）。该策略进一步用于对映体富集的大环化合物的快速构建。